Relationship between the paraoxonase 1 (PON1) M55L and Q192R polymorphisms and lymphohaematopoietic cancers in a Greek agricultural population

Kokouva, Maria; Koureas, Michalis; Dardiotis, Efthimios; Almpanidou, Pavlina; Kalogeraki, Alexandra; Kyriakou, Despoina; Hadjigeorgiou, Georgios M.; Hadjichristodoulou, Christos

doi:10.1016/j.tox.2012.07.003

Cited by 13 publications

(6 citation statements)

References 23 publications

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“…Moreover, there were 43 studies with 11412 cases and 13936 controls for PON1-Q192R polymorphism (Table 1), and, for PON1 L55M polymorphism, 28 studies involved a total of 8565 cases and 9996 controls (Table 2). For PON1 Q192R polymorphism, a total of 8 cancer types were processed, including breast cancer [21, 27, 31, 32, 37, 39, 50], prostate cancer [22, 23, 40, 41], gastrointestinal cancer [19, 20, 48, 59, 60], hematologic tumor [25, 29, 33, 44], lung cancer [11, 12, 54], brain tumors [30, 35, 38, 45, 56, 57], ovarian cancer [34, 43] and other cancers [13, 26, 28, 42, 53, 58] (uterine leiomyoma, childhood embryonal tumors, metastatic gastric cancer, bladder cancer, and renal cell cancer). Besides, we disposed a total of 7 cancer types when dealing with PON1-L55M polymorphism nearly like PON1 Q192R polymorphism.…”

Section: Resultsmentioning

confidence: 99%

The Association between PON1 (Q192R and L55M) Gene Polymorphisms and Risk of Cancer: A Meta-Analysis Based on 43 Studies

Pan

Huang

et al. 2019

BioMed Research International

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Q192R and L55M polymorphism were considered to be associated with the development of multiple cancers. Nevertheless, the results of these researches were inconclusive and controversial. Therefore, we conducted a meta-analysis of all eligible case-control studies to assess the association between PON1 (Q192R and L55M) gene polymorphisms and risk of cancer. With the STATA 14.0 software, we evaluated the strength of the association by using the odds ratios (ORs) and 95% confidence intervals (CIs). A total of 43 case-control publications 19887 cases and 23842 controls were employed in our study. In all genetic models, a significant association between PON1-L55M polymorphisms and overall cancer risk was observed. Moreover, in the stratified analyses by cancer type, polymorphism of PON1-L55M played a risk factor in the occurrence of breast cancer, hematologic cancer, and prostate cancer. Similarly, an increased risk was observed in the Caucasian and Asian population as well as hospital-based group and population-based group. For PON1-Q192R polymorphisms, in the stratified analyses by cancer type, PON1-Q192R allele was associated with reduced cancer risks in breast cancer. Furthermore, for racial stratification, there was a reduced risk of cancer in recession model in Caucasian population. Similarly, in the stratification analysis of control source, the overall risk of cancer was reduced in the heterozygote comparison and dominant model in the population-based group. In conclusion, PON1-Q192R allele decreased the cancer risk especially breast cancer; there was an association between PON1-L55M allele and increased overall cancer risk. However, we need a larger sample size, well-designed in future and at protein levels to confirm these findings.

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Section: Resultsmentioning

confidence: 99%

The Association between PON1 (Q192R and L55M) Gene Polymorphisms and Risk of Cancer: A Meta-Analysis Based on 43 Studies

Pan

Huang

et al. 2019

BioMed Research International

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“…Kokouva et al suggested that, based on a study on patients with lymphohematopoietic cancer from a region of Greece where intensive agricultural activities were performed, PON1 polymorphism could increase the risk of development of lymphohematopoietic malignancies in susceptible individuals exposed to pesticides (Kokouva et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Roles for Paraoxonase but not Ceruloplasmin in Peritoneal Washing Fluid in Differential Diagnosis of Gynecologic Pathologies

Yıldırım¹,

Demirpençe²,

Kaya³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Humbert et al found that the allele encoding arginine has high-activity plasma paraoxonase, whereas glutamine at this position specifies a low-activity variant [37]. The role of this SNP in haematological malignancies has only been studied in two independent studies which found an association of rs662 with lymphohaematopoietic cancers [38] and lymphoma [9]. …”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in xenobiotic metabolizing genes (EPHX1, NQO1 and PON1) in lymphoma susceptibility: a case control study

et al. 2013

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BackgroundThe interplay between genetic susceptibility and carcinogenic exposure is important in the development of haematopoietic malignancies. EPHX1, NQO1 and PON1 are three genes encoding proteins directly involved in the detoxification of potential carcinogens.MethodsWe have studied the prevalence of three functional polymorphisms affecting these genes rs1051740 EPHX1, rs1800566 NQO1 and rs662 PON1 in 215 patients with lymphoma and 214 healthy controls.ResultsGenotype frequencies for EPHX and NQO1 polymorphisms did not show any correlation with disease. In contrast, the GG genotype in the PON1 polymorphism was found to be strongly associated with the disease (15.3% vs. 4.7%; OR = 3.7 CI (95%): 1.8-7.7; p < 0.001). According to the pathological diagnosis this association was related to follicular (p = 0.004) and diffuse large B-cell (p = 0.016) lymphomas.ConclusionsDespite the fact that further confirmation is needed, this study shows that the PON1 GG genotype in rs662 polymorphism could be a risk factor for B-cell lymphomas.

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Relationship between the paraoxonase 1 (PON1) M55L and Q192R polymorphisms and lymphohaematopoietic cancers in a Greek agricultural population

Cited by 13 publications

References 23 publications

The Association between PON1 (Q192R and L55M) Gene Polymorphisms and Risk of Cancer: A Meta-Analysis Based on 43 Studies

The Association between PON1 (Q192R and L55M) Gene Polymorphisms and Risk of Cancer: A Meta-Analysis Based on 43 Studies

Roles for Paraoxonase but not Ceruloplasmin in Peritoneal Washing Fluid in Differential Diagnosis of Gynecologic Pathologies

Polymorphisms in xenobiotic metabolizing genes (EPHX1, NQO1 and PON1) in lymphoma susceptibility: a case control study

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