Relationship between the mean of 24-h venous blood glucose and in-hospital mortality among patients with subarachnoid hemorrhage: A matched cohort study

Abstract

ObjectiveThe aim of this study was to explore the correlation between the mean of 24-h venous blood glucose (BG) and in-hospital mortality and all-cause mortality (ACM) in patients with subarachnoid hemorrhage (SAH).MethodsDetailed clinical information was acquired from the Medical Information Mart for Intensive IV (MIMIC-IV) database. The best cutoff value of mean BG was calculated using the X-tile program. Univariate and multivariate logistic regressive analyses were utilized to analyze the prognosis significance of mean BG, and survival curves were drawn using the Kaplan-Meier (K-M) approach. To improve the reliability of results and balance the impact of underlying confounders, the 1:1 propensity score matching (PSM) approach was utilized.ResultsAn overall of 1,230 subjects were selected herein. The optimal cutoff value of the mean BG for in-hospital mortality was 152.25. In addition, 367 pairs of score-matched subjects were acquired after PSM analysis, and nearly all variables' differences were balanced. K-M analysis showed that patients with mean BG ≥ 152.25 mg/dl had significantly higher in-hospital, 3-month, and 6-month mortalities compared with patients with mean BG < 152.25 mg/dl (p < 0.001). The multivariable logistic regressive analyses revealed that patients with mean BG ≥ 152.25 mg/dl had significantly increased in-hospital mortality compared with patients with mean BG < 152.25 mg/dl after the adjustment for possible confounders (OR = 1.994, 95% CI: 1.321–3.012, p = 0.001). Similar outcomes were discovered in the PSM cohort.ConclusionOur data suggested that mean BG was related to ACM of patients with SAH. More studies are needed to further analyze the role of the mean of 24-h venous BG in patients with SAH.

Association of preoperative elevated lipoprotein (a) with poor survival in patients with biliary tract cancers

“…However, the underlying mechanisms remain unclear. Some studies have suggested that elevated Lp(a) levels may contribute to the formation of thrombi and fibrin networks, thereby promoting the adhesion, invasion, and metastasis of cancer cells 16 . However, animal studies have shown that the protein hydrolysate of Lp(a) exhibits anti‐tumor properties both in vivo and in vitro 18,19 .…”

“…Elevated Lp(a) levels have been linked to more aggressive forms of prostate 15 and colorectal cancers, 16 while no associations have been observed with breast cancer 17 . However, the underlying mechanisms remain unclear.…”

A predictive model using risk factor categories for hospital-acquired pneumonia in patients with aneurysmal subarachnoid hemorrhage

“…Blood glucose (>7.22 mmol/L) is a two-category variable applied to the risk threshold with a predictive value. High glucose levels are frequently associated with vasospasm, secondary ischemia, and poor outcomes ( 2 , 21 , 22 ). Hyperglycemia might be expected in aSAH patients due to the transient stress reaction and an acute metabolic response ( 21 ).…”