Microsurgical treatment yielded the best long-term resolution of patient symptoms to date and should be recommended to appropriately selected patients.

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The leucine-rich and immunoglobulin-like domains (LRIG) gene family contains LRIG1, 2 and 3. LRIG1 is a negative regulator of EGFR, but little is known about the function of LRIG2. To determine the role of LRIG2 in the progression of glioma, we performed RNA interference-mediated knockdown of LRIG2 in a human glioma cell line (GL15). Downregulation of LRIG2 expression resulted in: rapid EGF-mediated loss of EGFR; decreased proliferation; G(0)/G(1) arrest; increased spontaneous apoptosis; enhanced cell adhesion and increased invasion capability of GL15 cells in vitro. These findings indicate that LRIG2 possesses distinct functions compared with LRIG1 and validate the attractiveness of LRIG2 as a target in glioma therapy.

In this paper, a necessary and sufficient conditions for the strong convergence to a common fixed point of a finite family of continuous pseudocontractive mappings are proved in an arbitrary real Banach space using an implicit iteration scheme recently introduced by Xu and Ori [H.K. Xu, R.G. Ori, An implicit iteration process for nonexpansive mappings, Numer. Fuct. Anal. Optim. 22 (2001) 767-773] in condition α n ∈ (0, 1], and also strong and weak convergence theorem of a finite family of strictly pseudocontractive mappings of Browder-Petryshyn type is obtained. The results presented extend and improve the corresponding results of M.O. Osilike [M.O. Osilike, Implicit iteration process for common fixed points of a finite family of strictly pseudocontractive maps, J. Math.

Let E a real reflexive Banach space which admits a weakly sequentially continuous duality mapping from E to E * , and K be a closed convex subset of E which is also a sunny nonexpansive retract of E, and T : K → E be nonexpansive mappings satisfying the weakly inward condition and F (T ) = ∅, and f : K → K be a fixed contractive mapping. The implicit iterative sequence {x t } is defined by for t ∈ (0, 1)The explicit iterative sequence {x n } is given bywhere α n ∈ (0, 1) and P is sunny nonexpansive retraction of E onto K. We prove that {x t } strongly converges to a fixed point of T as t → 0, and {x n } strongly converges to a fixed point of T as α n satisfying appropriate conditions. The results presented extend and improve the corresponding results of [H.K. Xu, Viscosity approximation methods for nonexpansive mappings,

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