Relationship between the hs-CRP as non-specific biomarker and Alzheimer's disease according to aging process

Song, In‐Uk; Chung, Sung Woo; Kim, Young-Do; Maeng, Lee-So

doi:10.7150/ijms.12742

Cited by 41 publications

(31 citation statements)

References 17 publications

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“…In the current literature, the common ageing‐related diseases and conditions associated with increased CRP levels include CVD, hypertension, diabetes mellitus, chronic kidney injury, Alzheimer's disease and Parkinson's disease …”

Section: Crp and Ageing‐related Diseasementioning

confidence: 99%

“…C‐reactive protein, an acute phase protein, is primarily produced and secreted by the liver and is an important risk factor associated with ageing‐related diseases including cardiovascular disease (CVD), hypertension, diabetes mellitus, kidney disease and cognitive decline . However, recent studies have also shown that CRP is an important immunologic effector molecule with vital physiological functions .…”

Section: Introductionmentioning

confidence: 99%

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C‐reactive protein and ageing

Tang

Fung

et al. 2017

Clin Exp Pharma Physio

103

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SummaryIncreasing evidence shows that C-reactive protein (CRP) is not only an inflammatory biomarker but also an important risk factor associated with ageing-related diseases including cardiovascular disease, hypertension, diabetes mellitus, and kidney disease.Recent studies have demonstrated that CRP is pathogenic in a number of diseases including hypertensive cardiovascular and kidney complications, diabetic nephropathy, and acute and chronic kidney diseases. It is well known that CRP binds its receptor, CD32/CD64, to induce the process of inflammation by activating the NF-κB signalling pathway. In addition, CRP mediates tissue fibrosis in a number of cardiovascular and kidney diseases by activating TGF-β/Smad signalling via TGF-β1-dependent and independent mechanisms. Furthermore, CRP is able to activate mTOR signalling in the diabetic conditions. Our recent studies also revealed that CRP impairs cell regeneration by causing the G1 cell cycle arrest and promotes ageing via a Smad3-dependent

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Section: Crp and Ageing‐related Diseasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

C‐reactive protein and ageing

Tang

Fung

et al. 2017

Clin Exp Pharma Physio

103

View full text Add to dashboard Cite

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“…According to some authors, CRP is a peripheral biomarker that reflects peripheral and central inflammation (and neuroinflammation) (Felger et al 2018). Elevated systemic CRP levels have been noted in numerous conditions associated with peripheral and central neural damage as well as impaired neuroprotection, i.e., Alzheimer's disease (Song et al 2015;Kempuraj et al 2017;Gabin et al 2018), Parkinson's disease (Sawada et al 2015;Umemura et al 2015;Qiu et al 2019), depression (Felger et al 2018), opioid use disorder , or following chimeric antigen receptor T cell (CAR-T) therapy in cancer (Santomasso et al 2018;Wang and Han 2018). To justify our choice of markers, it should also be mentioned that both TNFα and CRP in serum have been evaluated in parkinsonian patients and correlated with motor deficits (Lindqvist et al 2012;Eidson et al 2017).…”

Section: Analytical Methods Reference Bananamentioning

confidence: 99%

Salsolinol—neurotoxic or Neuroprotective?

et al. 2019

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Salsolinol (6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline), widely available in many edibles, is considered to alter the function of dopaminergic neurons in the central nervous system and thus, multiple hypotheses on its either physiological and/or pathophysiological role have emerged. The aim of our work was to revisit its potentially neurotoxic and/or neuroprotective role through a series of both in vitro and in vivo experiments. Salsolinol in the concentration range 10-250 μM did not show any significant release of lactate dehydrogenase from necrotic SH-SY5Y cells and was able in the concentration of 50 and 100 μM to rescue SH-SY5Y cells from death induced by H 2 O 2. Its neuroprotective effect against neurotoxin 6-hydroxydopamine was also determined. Salsolinol was found to decrease significantly the reactive oxygen species level in SH-SY5Y cells treated by 500 μM H 2 O 2 and the caspase activity induced by 300 μM of H 2 O 2 or 100 μM of 6-hydroxydopamine. Serum levels of TNFα and CRP of salsolinol-treated rats were not significantly different from control animals. Both TNFα and CRP served as indirect markers of neurotoxicity and/or neuroprotection. Although the neurotoxic properties of salsolinol have numerously been emphasized, its neuroprotective properties should not be neglected and need greater consideration.

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“…Similar dispute is also found in levels of CRP. Despite the findings that CRP was decreased in AD patients, a recent study provided opposite results 19,20 .…”

mentioning

confidence: 93%

Complement factor H levels are decreased and correlated with serum C-reactive protein in late-onset Alzheimer's disease

Liu

Huang

et al. 2020

Arq. Neuro-Psiquiatr.

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Alzheimer’s disease (AD) is the most common cause of dementia. Despite numerous studies on the subject, the pathologies for AD are still unclear and there is still no ideal biomarker for diagnosis. The present study aimed to investigate clinical significance of human complement factor H (CFH) in patients with late-onset AD. Methods: The present prospective study included 187 late-onset AD patients who went to our hospital from January 2015 to December 2017. One hundred patients with mild cognitive impairment (MCI) and 80 healthy individuals who were age and gender matched to AD patients were enrolled as controls. Demographic data such as age, gender, and education duration were recorded. Blood samples were collected and serum levels of C-reactive protein (CRP), CFH, and brain-derived neurotrophic factor (BDNF) were determined by Enzyme-linked immunosorbent assay (ELISA). The mini-mental state examination (MMSE) score was measured for all patients. Results: No significant difference was found in age, gender, and education duration for all participants. The MMSE scores showed AD patients had lower MMES scores than the other two groups. All factors of CFH, CRP, and BDNF were dramatically decreased in AD patients compared with the MCI and the ealthy control. Levels of CFH were found to be positively correlated with levels of CRP; however, no significant correlation was found between CFH and BDNF, nor CFH and MMSE. Conclusion: CFH was decreased in late-onset AD patients, and serum levels of CFH was correlated with serum levels of CRP, but not MMSE and BDNF. These results may provide more clinical evidences for the role of CFH in AD patients.

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Relationship between the hs-CRP as non-specific biomarker and Alzheimer's disease according to aging process

Cited by 41 publications

References 17 publications

C‐reactive protein and ageing

C‐reactive protein and ageing

Salsolinol—neurotoxic or Neuroprotective?

Complement factor H levels are decreased and correlated with serum C-reactive protein in late-onset Alzheimer's disease

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