Relationship Between the Estimated Glomerular Filtration Rate and Kidney Shear Wave Speed Values Assessed by Acoustic Radiation Force Impulse Elastography

Bob, Flaviu; Bota, Simona; Sporea, Ioan; Şirli, Roxana; Popescu, Alina; Schiller, Adalbert

doi:10.7863/ultra.34.4.649

Cited by 53 publications

(56 citation statements)

References 23 publications

(35 reference statements)

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“…In the control group we found an indirect correlation between age and kidney SWV similar to previously published studies [12,14]. The relationship between renal stiffness and age could also be related to the decreased renal blood flow in elderly.…”

Section: Discussionsupporting

confidence: 90%

“…As mentioned above, data available so far regarding the use of VTQ elastography in the kidneys showed that kidney SWV is decreasing with the progression of kidney disease, which is contradictory to the data available for the liver, where liver fibrosis is associated with an increase in liver SWV [12,14,15]. In our study group, we confirmed previous observations regarding the fact that kidney SWV is significantly lower in patients with CGN as compared to normal controls.…”

Section: Discussionsupporting

confidence: 68%

“…Unlike the liver, which shows an increase in stiffness with the pro-gression of liver fibrosis, kidney SWV is decreasing with the progression of chronic kidney disease [12,14,15]. The question is how does the progression of renal fibrosis influence kidney SWV?…”

Section: Introductionmentioning

confidence: 99%

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Is there a correlation between kidney shear wave velocity measured with VTQ and histological parameters in patients with chronic glomerulonephritis? A pilot study

Bob¹,

Grosu²,

Sporea³

et al. 2018

Med Ultrason

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Aim: To analyze the relationship between shear wave velocity in the kidney measured by point shear wave elastography using Virtual Touch Quantification (VTQ) (Siemens Acuson S2000) and histological parameters obtained from renal biopsies, in patients with chronic glomerulonephritis (CGN).Material and methods: The study group included 20 patients (mean age 47.95±13.59 years) with different types of CGN, that had underwent renal biopsy and 57 normal controls (mean age 38.07±17.32 years). In all patients, five valid stiffness measurements were obtained in each kidney, with the patient in lateral decubitus. Regarding the histological results, we assessed the presence or absence of glomerulosclerosis, interstitial fibrosis, and arteriolo-hyalinosis.Results: In patients with CGN we obtained the following mean values of VTQ values: right kidney: 2.12±0.81 m/s, left kidney 1.65±0.54 m/s, while in the normal controls significantly higher VTQ values were obtained: right kidney 2.69±0.72 m/s (p=0.004), left kidney 2.48±0.73 m/s (p<0.0001). In patients with CGN no statistically significant correlations between VTQ values and eGFR (r=0.37, p=0.12) or proteinuria (r=0.2, p=0.37) were found. We found significantly lower VTQ values in patients with interstitial fibrosis (1.46 vs. 1.99 m/s, p<0.05) and also in patients with arteriolo-hyalinosis (1.55 vs. 2.47 m/s, p<0.05).Conclusion: Our pilot study shows that shear wave velocity values in patients with CGN are significantly lower compared to normal controls, and there is a tendency to decrease with the decrease of eGFR, with the presence of interstitial fibrosis and of arteriolo-hyalinosis.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 68%

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Is there a correlation between kidney shear wave velocity measured with VTQ and histological parameters in patients with chronic glomerulonephritis? A pilot study

Bob¹,

Grosu²,

Sporea³

et al. 2018

Med Ultrason

Self Cite

View full text Add to dashboard Cite

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“…Comparing mean SWS values of measurements in left and right kidneys, we found no significant difference except for the VTQ method, using the 1-6 MHz ultrasound probe with a dorsal approach. This is in concordance with previous studies in adult kidneys, which also did not show a difference between the left and right kidney [26,27]. However, data in pediatric studies are not consistent.…”

Section: Discussionsupporting

confidence: 89%

Point shear wave elastography (pSWE) using Acoustic Radiation Force Impulse (ARFI) imaging: a feasibility study and norm values for renal parenchymal stiffness in healthy children and adolescents

et al. 2017

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Aims: To evaluate the applicability of point shear wave elastography (pSWE) for measuring renal parenchymal stiffness in healthy children and adolescents and to establish norm values for shear wave speed (SWS) using two ARFI methods and ultrasound probes.Material and methods: We prospectively investigated 264 children (43.9% males). pSWE (Virtual TouchTM Quantification and Virtual TouchTM Imaging Quantification (VTQ and VTIQ; Siemens, Germany)) was performed in the renal cortex of 528 healthy kidneys using a 1-6 MHz convex and a 4-9 MHz linear ultrasound probe in ventrolateral and dorsal examinations. Feasibility and reproducibility of pSWE measurements were evaluated. SWS values were analysed with regard to age, body dimensions, kidney volume and measuring depth.Results: pSWE measurements were successful in >95% of subjects using the low and in <60% using the high-frequency probe. Mean SWS values (m/s) differed by method and probe: 2.10±0.43 (VTQ1-6MHz, convex, ventrolateral), 2.30±0.37 (VTQ1-6MHz, convex, dorsal), 1.58±0.44 (VTQ4-9MHz, linear, dorsal) and 1.96±0.27 (VTIQ4-9MHz, linear, dorsal). SWS was positively correlated with age, weight and body height, but independent of sex, BMI, or kidney volume and depth.Conclusions: pSWE (VTQ) is a feasible method to evaluate renal parenchymal stiffness in children of all ages. SWS values are age and weight dependent and differ significantly between high- and low-frequency probes. High-frequency probes and VTIQ should only be used in children <10 years.

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“…For example, Bob et al showed that the shear wave velocity decreased with increasing CKD stage (Table 4, 104). This is supported by other studies that found significantly decreased shear wave velocity in CKD compared to normal kidneys (Table 4 103, 105).…”

Section: Clinical Applications Of Ultrasound Elastographymentioning

confidence: 99%

Ultrasound Elastography: Review of Techniques and Clinical Applications

et al. 2017

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Elastography-based imaging techniques have received substantial attention in recent years for non-invasive assessment of tissue mechanical properties. These techniques take advantage of changed soft tissue elasticity in various pathologies to yield qualitative and quantitative information that can be used for diagnostic purposes. Measurements are acquired in specialized imaging modes that can detect tissue stiffness in response to an applied mechanical force (compression or shear wave). Ultrasound-based methods are of particular interest due to its many inherent advantages, such as wide availability including at the bedside and relatively low cost. Several ultrasound elastography techniques using different excitation methods have been developed. In general, these can be classified into strain imaging methods that use internal or external compression stimuli, and shear wave imaging that use ultrasound-generated traveling shear wave stimuli. While ultrasound elastography has shown promising results for non-invasive assessment of liver fibrosis, new applications in breast, thyroid, prostate, kidney and lymph node imaging are emerging.Here, we review the basic principles, foundation physics, and limitations of ultrasound elastography and summarize its current clinical use and ongoing developments in various clinical applications.

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Relationship Between the Estimated Glomerular Filtration Rate and Kidney Shear Wave Speed Values Assessed by Acoustic Radiation Force Impulse Elastography

Abstract: Kidney shear wave speed values obtained by ARFI elastography decrease with the decrease in the estimated GFR.

Cited by 53 publications

References 23 publications

Is there a correlation between kidney shear wave velocity measured with VTQ and histological parameters in patients with chronic glomerulonephritis? A pilot study

Is there a correlation between kidney shear wave velocity measured with VTQ and histological parameters in patients with chronic glomerulonephritis? A pilot study

Point shear wave elastography (pSWE) using Acoustic Radiation Force Impulse (ARFI) imaging: a feasibility study and norm values for renal parenchymal stiffness in healthy children and adolescents

Ultrasound Elastography: Review of Techniques and Clinical Applications

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