Viticultural by-products are known to contain high-value compounds such as stilbenes. Wine sector in Savoie Mont Blanc region (France) generates high amount of waste including grape canes and grapevine stocks that remain unvalued. Herein, the potential of the most widespread grapevine varieties in Savoie Mont Blanc territory, Jacquère and Mondeuse, as sources of two stilbenes, trans-resveratrol (Rsv) and trans-ε-viniferin (Vf) was investigated for the first time. Using the reported extraction technique, the present work focused on several preextraction parameters influencing the extraction efficiency, including grapevine variety, age of 2 vines, time of material storage and particles size of the woody material. This work revealed important Rsv and Vf contents in Jacquère residues of 1681-6124 mg.kg-1 dw and 1620-6667 mg.kg-1 dw respectively, whereas for Mondeuse variety, the target molecules yields were 1724-4636 mg.kg-1 dw and 1713-5322 mg.kg-1 dw respectively. These results are promising when compared with high well-known stilbenes levels in Pinot Noir and Gewurztraminer varieties but also highlight a considerable variability depending on the applied pre-extraction parameters.