Relationship between the Effect of Dietary Fat on Swimming Endurance and Energy Metabolism in Aged Mice

Shirai, Nobuyuki; Suzuki, Haruo

doi:10.1159/000331213

Cited by 5 publications

(4 citation statements)

References 69 publications

(46 reference statements)

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“…Emerging evidence demonstrated that persistent fatigue occurs when the body kinetic energy consumption exceeds the cells energy supply capacity. Physical fatigue is almost accompanied by metabolic disorders, mainly liver glycogen and muscle glycogen metabolism [52]. In fact, behind the metabolic disorders we can still see the “shadow” of inflammatory responses, which affect the host metabolism and neuroendocrine reactions and induce or promote fatigue symptoms [53].…”

Section: Discussionmentioning

confidence: 99%

Effect of the Chinese Medicine YangZheng XiaoJi on Reducing Fatigue in Mice with Orthotopic Transplantation of Colon Cancer

Zhang

Zhao

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Background. Fatigue is a common, distressing, and persistent symptom for patients with malignant tumor including colorectal cancer (CRC). Although studies of cancer-related fatigue (CRF) have sprung out in recent years, the pathophysiological mechanisms that induce CRF remain unclear, and effective therapeutic interventions have yet to be established. Methods. To investigate the effect of the traditional Chinese medicine YangZheng XiaoJi (YZXJ) on CRF, we constructed orthotopic colon cancer mice, randomly divided into YZXJ group and control (NS) group. Physical or mental fatigue was respectively assessed by swimming exhaustion time or suspension tail resting time. At the end of the experiment, serum was collected to measure the expression level of inflammatory factors by ELISA and feces to microbiota changes by 16s rDNA, and hepatic glycogen content was detected via the anthrone method. Result. The nutritional status of the YZXJ group was better than that of the control group, and there was no statistical difference in tumor weight. The swimming exhaustion times of YZXJ group and control group were (162.80 ± 14.67) s and (117.60 ± 13.42, P < 0.05) s, respectively; the suspension tail resting time of YZXJ group was shorter than that of the control group (49.85 ± 4.56) s and (68.83 ± 7.26) s, P < 0.05)). Serum levels of IL-1β and IL-6 in YZXJ group were significantly lower than the control group (P < 0.05). Liver glycogen in YZXJ group was (5.18 ± 3.11) mg/g liver tissue, which was significantly higher than that in control group (2.95 ± 2.06) mg/g liver tissue (P < 0.05). At phylum level, increased abundance of Bacteroidetes, Verrucomicrobia, Actinobacteria, and Cyanobacteria and decreased Proteobacteria in YZXJ group emerged as the top differences between the two groups, and the Firmicutes/Bacteroidetes ratio was decreased in YZXJ group compared to the control group. At genus level, the abundance of Parabacteroides, unidentified Saprospiraceae, and Elizabethkingia which all belong to phylum Bacteroidetes were increased, while Arcobacter, Marinobacter, Alkanindiges, Sulfuricurvum, Haliangium, and Thiobacillus in phylum Proteobacteria were decreased after YZXJ intervention. YZXJ can also increase Pirellula, Microbacterium, and Alpinimonas and decrease Rubrobacter and Iamia. Conclusion. YZXJ may reduce the physical and mental fatigue caused by colorectal cancer by inhibiting inflammatory reaction, promoting hepatic glycogen synthesis, and changing the composition of intestinal microbiota.

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Section: Discussionmentioning

confidence: 99%

Effect of the Chinese Medicine YangZheng XiaoJi on Reducing Fatigue in Mice with Orthotopic Transplantation of Colon Cancer

Zhang

Zhao

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…DHA SUPPLEMENTATION AND MUSCLE MITOCHONDRIAL FUNCTION that lipid consumption can increase exercise tolerance in middle-aged mice (29,50,64). However, the underlying mechanisms of such positive effects still remain unclear.…”

Section: E219mentioning

confidence: 99%

A 9-wk docosahexaenoic acid-enriched supplementation improves endurance exercise capacity and skeletal muscle mitochondrial function in adult rats

Guen

Chaté

Hininger‐Favier

et al. 2016

American Journal of Physiology-Endocrinology and Metabolism

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Among the causes, modifications of the mitochondrial function could be of major importance. Polyunsaturated fatty (-3) acids have been shown to play a role in intracellular functions. We hypothesize that docosahexaenoic acid (DHA) supplementation could improve muscle mitochondrial function that could contribute to limit the early consequences of aging on adult muscle. Twelve-month-old male Wistar rats were fed a low-polyunsaturated fat diet and were given DHA (DHA group) or placebo (control group) for 9 wk. Rats from the DHA group showed a higher endurance capacity (ϩ56%, P Ͻ 0.05) compared with control animals. Permeabilized myofibers from soleus muscle showed higher O2 consumptions (P Ͻ 0.05) in the DHA group compared with the control group, with glutamate-malate as substrates, both in basal conditions (i.e., state 2) and under maximal conditions (i.e., state 3, using ADP), along with a higher apparent Km for ADP (P Ͻ 0.05). Calcium retention capacity of isolated mitochondria was lower in DHA group compared with the control group (P Ͻ 0.05). Phospho-AMPK/AMPK ratio and PPAR␦ mRNA content were higher in the DHA group compared with the control group (P Ͻ 0.05). Results showed that DHA enhanced endurance capacity in adult animals, a beneficial effect potentially resulting from improvement in mitochondrial function, as suggested by our results on permeabilized fibers. DHA supplementation could be of potential interest for the muscle function in adults and for fighting the decline in exercise tolerance with age that could imply energy-sensing pathway, as suggested by changes in phospho-AMPK/AMPK ratio. polyunsaturated fatty acids; isolated mitochondria; permeabilized myofibers; muscle bioenergetics AGING IS ASSOCIATED WITH A PROGRESSIVE DECREASE in muscle mass and alterations in muscle function leading to reduced physical abilities, exercise performance and quality of life, and ultimately disabilities (21,26,36). Among the causes of such sarcopenia, inadequate protein synthesis matching protein degradations is of major importance (4, 12). Also, changes in metabolism could be part of the muscle mass decrease with age.

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“…This mechanism help controlling hepatic inflammation (Ramanan et al, 2008). Endurance exercise has been suggested as a modulator of PPARa mRNA expression in the liver (Maciejewska et al, 2011;Zhang et al, 2011).…”

mentioning

confidence: 99%

Association Between Aerobic Exercise and Rosiglitazone Avoided the NAFLD and Liver Inflammation Exacerbated in PPAR‐α Knockout Mice

Batatinha

Lima

Teixeira

et al. 2016

Journal Cellular Physiology

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Nonalcoholic fatty liver disease (NAFLD) is one of the main liver diseases today, and may progress to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Some studies have shown the beneficial effects of aerobic exercise on reversing NAFLD. To verify whether chronic aerobic exercise improves the insulin resistance, liver inflammation, and steatohepatitis caused by a high fat diet (HF) and whether PPARα is involved in these actions. C57BL6 wild type (WT) and PPAR-α knockout (KO) mice were fed with a standard diet (SD) or HF during 12 weeks; the HF mice were trained on a treadmill during the last 8 weeks. Serum glucose and insulin tolerances, serum levels of aspartate aminotransferase, hepatic content of triacylglycerol, cytokines, gene expression, and protein expression were evaluated in all animals. Chronic exposure to HF diet increased triacylglycerol accumulation in the liver, leading to NAFLD, increased aminotransferase in the serum, increased peripheral insulin resistance, and higher adiposity index. Exercise reduced all these parameters in both animal genotypes. The liver lipid accumulation was not associated with inflammation; trained KO mice, however, presented a huge inflammatory response that was probably caused by a decrease in PPAR-γ expression. We conclude that exercise improved the damage caused by a HF independently of PPARα, apparently by a peripheral fatty acid oxidation in the skeletal muscle. We also found that the absence of PPARα together with exercise leads to a decrease in PPAR-γ and a huge inflammatory response. J. Cell. Physiol. 232: 1008-1019, 2017. © 2016 Wiley Periodicals, Inc.

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Relationship between the Effect of Dietary Fat on Swimming Endurance and Energy Metabolism in Aged Mice

Cited by 5 publications

References 69 publications

Effect of the Chinese Medicine YangZheng XiaoJi on Reducing Fatigue in Mice with Orthotopic Transplantation of Colon Cancer

Effect of the Chinese Medicine YangZheng XiaoJi on Reducing Fatigue in Mice with Orthotopic Transplantation of Colon Cancer

A 9-wk docosahexaenoic acid-enriched supplementation improves endurance exercise capacity and skeletal muscle mitochondrial function in adult rats

Association Between Aerobic Exercise and Rosiglitazone Avoided the NAFLD and Liver Inflammation Exacerbated in PPAR‐α Knockout Mice

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