Relationship between the distribution of plasma HDL subclasses and the polymorphisms of APOA5 in hypertriglyceridemia

Long, Shiyin; Chen, Zhijun; Ying, Han; Christopher, Devin M.; Zhang, Caiping; Yang, Ying; Tian, Ying

doi:10.1016/j.clinbiochem.2013.03.003

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…Moreover, ApoA5 protein is a component of HDL particles, and its absence might result in unstable HDL that is easily eliminated from serum [ 72 ]. Furthermore, Apoa5 mutation can result in impaired reverse cholesterol transport and abnormal HDL maturation, resulting in a decrease in the total amount of HDL [ 73 ].…”

Section: Discussionmentioning

confidence: 99%

Association between APOA5 polymorphisms and susceptibility to metabolic syndrome: a systematic review and meta-analysis

Mozafari,

Ashoori,

Emami Meybodi

et al. 2024

BMC Genomics

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Background The association between Apolipoprotein A5 (APOA5) genetic polymorphisms and susceptibility to metabolic syndrome (MetS) has been established by many studies, but there have been conflicting results from the literature. We performed a meta-analysis of observational studies to evaluate the association between APOA5 gene polymorphisms and the prevalence of MetS. Methods PubMed, Web of Science, Embase, and Scopus were searched up to April 2024. The random effects model was used to estimate the odds ratios (ORs) and 95% confidence intervals (CI) of the association between APOA5 gene polymorphisms and the prevalence of MetS development. The potential sources of heterogeneity were evaluated by subgroup analyses and sensitivity analyses. Results A total of 30 studies with 54,986 subjects (25,341 MetS cases and 29,645 healthy controls) were included. The presence of rs662799 and rs651821 polymorphisms is associated with an approximately 1.5-fold higher likelihood of MetS prevalence (OR = 1.42, 95% CI: 1.32, 1.53, p < 0.001; I2 = 67.1%; P-heterogeneity < 0.001; and OR = 1.50, 95% CI: 1.36–1.65, p < 0.001), respectively. MetS is also more prevalent in individuals with the genetic variants rs3135506 and rs2075291. There was no evidence of a connection with rs126317. Conclusion The present findings suggest that polymorphisms located in the promoter and coding regions of the APOA5 gene are associated with an increased prevalence of MetS in the adult population. Identifying individuals with these genetic variations could lead to early disease detection and the implementation of preventive strategies to reduce the risk of MetS and its related health issues. However, because the sample size was small and there was evidence of significant heterogeneity for some APOA5 gene polymorphisms, these results need to be confirmed by more large-scale and well-designed studies.

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Section: Discussionmentioning

confidence: 99%

Association between APOA5 polymorphisms and susceptibility to metabolic syndrome: a systematic review and meta-analysis

Mozafari,

Ashoori,

Emami Meybodi

et al. 2024

BMC Genomics

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“…The most significant impact on plasma triglycerides (TG) levels seems to be associated with ApoA5 gene (ID 116519, OMIM accession number 606368) variants [ 6 , 7 ]. ApoA5 is located on TG-rich and high density lipoprotein (HDL) particles, enhances the activity of lipoprotein lipase [ 7 , 8 ], and recombinant apoA5 binds to the LDL receptor family members [ 9 ]. Previous studies suggested that minor alleles of two SNPs (rs662799 and rs3135506) in ApoA5 gene were associated with elevated plasma TG levels, regardless of ethnicity and sex [ 10 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Association of apolipoprotein A5 genetic polymorphisms with steroid-induced osteonecrosis of femoral head in a Chinese Han population

et al. 2014

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BackgroundPrevious studies suggested that apolipoprotein A5 (ApoA5) genetic polymorphisms (SNPs) may result in lipid metabolism disorders. Therefore, genetic polymorphisms in ApoA5 may be associated with the occurrence of osteonecrosis of femoral head (ONFH).MethodsWe designed a case–control study including 223 patients of osteonecrosis and 201 age- and sex-matched control subjects to analyze the association between ApoA5 polymorphisms and susceptibility of steroid-induced ONFH. We utilized polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method to genotype two SNPs (rs662799 and rs3135506) in ApoA5 gene.ResultsWe found both rs662799 and rs3135506 were associated with the risk of ONFH in codominant, dominant, and recessive model, respectively. Haplotype analyses suggested that T-C haplotype was associated with decreased risk of ONFH, whereas the haplotype C-C was significantly associated with an increased risk of ONFH.ConclusionOur study suggested that ApoA5 genetic polymorphisms were associated with susceptibility to ONFH in Chinese population. However, our results need further investigation with large sample size and various populations.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_229

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Association between apolipoprotein gene polymorphisms and hyperlipidemia: a meta-analysis

et al. 2021

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Background Hyperlipidemia plays an important role in the etiology of cardio-cerebrovascular disease. Over recent years, a number of studies have explored the impact of apolipoprotein genetic polymorphisms in hyperlipidemia, but considerable differences and uncertainty have been found in their association with different populations from different regions. Results A total of 59 articles were included, containing in total 13,843 hyperlipidemia patients in the case group and 15,398 healthy controls in the control group. Meta-analysis of the data indicated that APOA5–1131 T > C, APOA1 -75 bp, APOB XbaI, and APOE gene polymorphisms were significantly associated with hyperlipidemia, with OR values of 1.996, 1.228, 1.444, and 1.710, respectively. All P-values were less than 0.05. Conclusions Meta-analysis of the data indicated that the C allele of APOA5 1131 T > C, the A allele at APOA1-75 bp, the APOB XbaI T allele, and the ε2 and ε4 allele of APOE were each a risk factor for susceptibility for hyperlipidemia.

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Relationship between the distribution of plasma HDL subclasses and the polymorphisms of APOA5 in hypertriglyceridemia

Cited by 4 publications

References 37 publications

Association between APOA5 polymorphisms and susceptibility to metabolic syndrome: a systematic review and meta-analysis

Association between APOA5 polymorphisms and susceptibility to metabolic syndrome: a systematic review and meta-analysis

Association of apolipoprotein A5 genetic polymorphisms with steroid-induced osteonecrosis of femoral head in a Chinese Han population

Association between apolipoprotein gene polymorphisms and hyperlipidemia: a meta-analysis

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