Relationship between TG/HDL-C ratio and metabolic syndrome risk factors with chronic kidney disease in healthy adult population

Ho, Cheng-Ting; Chen, Jau Yuan; Chen, Shou Yen; Tsai, Yi Wen; Weng, Yi Ming; Tsao, Yu-Chung; Li, Wen Cheng

doi:10.1016/j.clnu.2014.09.007

Cited by 37 publications

(28 citation statements)

References 40 publications

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“…Apart from above investigations, researches also identified the utility of TG/HDL-C in identifying eGFR reduction as it incorporated both TG and HDL-C level. Ho et al demonstrated the correlation between TG/HDL-C with CKD, and Wen et al even showed the advantage of TG/HDL-C when compared with TG alone with respect to the development of CKD, confirmed our aforementioned hypothesis [ 13 , 14 ]. However, there was one point that worth to be mentioned, although TG/HDL-C had a robust association with CKD, it was not an ideal marker of eGFR reduction due to its low sensitivity and specificity [ 13 ].…”

Section: Discussionsupporting

confidence: 85%

Value of reduced glomerular filtration rate assessment with cardiometabolic index: insights from a population-based Chinese cohort

Wang

Shi

Yi³

et al. 2018

BMC Nephrol

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BackgroundRecent studies have suggested that cardiometabolic index (CMI), a novel estimate of visceral adipose tissue, could be of use in the evaluation of cardiovascular risk factors. However, the potential utility and clinical significance of CMI in the detection of reduced estimated glomerular filtration rate (eGFR) remains uncertain. The purpose of this study was to investigate the usefulness of CMI in assessing reduced eGFR in the general Chinese population.MethodsThis cross-sectional analysis included 11,578 participants (mean age: 53.8 years, 53.7% females) from Northeast China Rural Cardiovascular Health Study (NCRCHS) of general Chinese population (data collected from January 2013 to August 2013). CMI was calculated by triglyceride to high density lipoprotein cholesterol ratio multiply waist-to-height ratio. Reduced eGFR was defined as eGFR< 60 ml/min per 1.73m2. Multivariate regressions were performed to determine CMI’s association with eGFR value and eGFR reduction, ROC analyses were employed to investigate CMI’s discriminating ability for decreased eGFR.ResultsThe prevalence of reduced eGFR was 1.7% in males and 2.5% in females. CMI was notably more adverse in reduced eGFR groups, regardless of genders. In fully adjusted multivariate linear models, each 1 SD increment of CMI caused 3.150 ml/min per 1.73m2 and 2.411 ml/min per 1.73m2 loss of eGFR before CMI reached 1.210 and 1.520 in males and females, respectively. In logistic regression analyses, per 1 SD increase of CMI brought 51.6% additional risk of reduced eGFR in males while caused 1.347 times of risk in females. After divided into quartiles, people in the top quartile of CMI had higher adjusted ORs of having reduced eGFR, with ORs of 4.227 (1.681, 10.627) and 3.442 (1.685–7.031) for males and females respectively. AUC of CMI was revealed to be 0.633 (0.620–0.646) in males and 0.684 (0.672–0.695) in females.ConclusionsHigher CMI was independently associated with greater burden of reduced eGFR, highlighting VAT distribution and dysfunction as a potential mechanism underlying the association of obesity with kidney damage and adverse cardiovascular outcomes. The findings from this study provided important insights regarding the potential usefulness and clinical relevance of CMI in the detection of reduced eGFR among general Chinese population.

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Section: Discussionsupporting

confidence: 85%

Value of reduced glomerular filtration rate assessment with cardiometabolic index: insights from a population-based Chinese cohort

Wang

Shi

Yi³

et al. 2018

BMC Nephrol

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“…However, the TC/HDL, LDL/HDL and TG/HDL ratios, which are considered markers of diabetic dyslipidemia [30,31] did not change after HP-EVOO intake.…”

Section: Discussionmentioning

confidence: 67%

Consumption of extra-virgin olive oil rich in phenolic compounds improves metabolic control in patients with type 2 diabetes mellitus: a possible involvement of reduced levels of circulating visfatin

Santangelo

Filesi

Varı̀

et al. 2016

J Endocrinol Invest

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“…Several studies have reported that an elevated TG/ HDL-C ratio correlated with the prevalence of CKD [14,15]. However, conflicting data were reported on the association of high TG/HDL-C ratios with CVD and mortality in dialysis patients.…”

Section: Introductionmentioning

confidence: 99%

Elevated TG/HDL-C and non-HDL-C/HDL-C ratios predict mortality in peritoneal dialysis patients

et al. 2020

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Background and aims: Dyslipidemia is common in patients with chronic kidney disease and particular prevalent in patients receiving peritoneal dialysis. However, whether markers of atherogenic dyslipidemia correlate with outcomes in dialysis patients as in the general population is uncertain. The aim of this study was to explore the prognostic value of the serum triglyceride/HDL cholesterol (TG/HDL-C) ratio and non-HDL-C/HDL-C ratio to predict mortality in peritoneal dialysis patients. Methods: Two hundred fourteen peritoneal dialysis patients were retrospectively analyzed from January 2011 to December 2015, with a median follow-up of 59 months. We used receiver operating curves (ROC) to determine the optimal threshold for TG/HDL-C and non-HDL/HDL-C ratios at baseline to predict overall survival during follow-up. Prognostic values were accessed by univariate and multivariate COX regression analysis and Kaplan-Meier curve. A predictive nomogram was developed to predict prognosis for overall survival, and the predictive accuracy was evaluated by concordance index (c-index). Results: The optimal cutoff values for TG/HDL-C ratio and non-HDL-C/HDL-C ratio to predict mortality were 1.94 and 2.86, respectively. A high TG/HDL-C ratio and a high non-HDL-C/HDL-C ratio strongly correlated with worse overall survival in peritoneal dialysis patients. Multivariate analysis demonstrated that elevated TG/HDL-C ratio (HR 3.57, 95% CI 1.99, 6.39, P < 0.000) as well as non-HDL/HDL-C ratio (HR 2.58, 95%CI 1.39-4.81, P = 0.003) were independent markers to predict reduced OS. A nomogram was constructed to predict overall survival, with a cindex for predictive accuracy of 0.795. Conclusion: TG/HDL-C ratio and non-HDL-C/HDL-C may serve as potential prognostic biomarkers in PD patients.

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Relationship between TG/HDL-C ratio and metabolic syndrome risk factors with chronic kidney disease in healthy adult population

Cited by 37 publications

References 40 publications

Value of reduced glomerular filtration rate assessment with cardiometabolic index: insights from a population-based Chinese cohort

Value of reduced glomerular filtration rate assessment with cardiometabolic index: insights from a population-based Chinese cohort

Consumption of extra-virgin olive oil rich in phenolic compounds improves metabolic control in patients with type 2 diabetes mellitus: a possible involvement of reduced levels of circulating visfatin

Elevated TG/HDL-C and non-HDL-C/HDL-C ratios predict mortality in peritoneal dialysis patients

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