Relationship between splenic sequestration and thrombocytopenia in Trypanosoma evansi infection in rats

Kipper, Marcos; Silva, A.S. Da; Oliveira, Camila Belmonte; Andretta, Inés; Paim, Francine C.; Silva, C.B. da; León, Ricardo Medina-Coss y; Corrêa, Krislainy de Sousa; Stainki, Daniel Roulim; Lopes, Sonia T.A.; Monteiro, Sílvia González

doi:10.1016/j.rvsc.2010.11.018

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…There is an array of possible reasons for a decrease in platelet numbers associated with T . evansi infection, including reduction of the platelet life span, splenic and hepatic sequestration, self-immune response and/or disseminated intravascular coagulation, characterized by systemic activation of blood coagulation, due to constant contact with trypomastigote forms and the vascular endothelium [ 12 , 69 , 70 ].…”

Section: Discussionmentioning

confidence: 99%

Co-Infection and Wild Animal Health: Effects of Trypanosomatids and Gastrointestinal Parasites on Coatis of the Brazilian Pantanal

et al. 2015

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Wild animals are infected by diverse parasites, but how they influence host health is poorly understood. We examined the relationship of trypanosomatids and gastrointestinal parasites with health of wild brown-nosed coatis (Nasua nasua) from the Brazilian Pantanal. We used coati body condition and hematological parameters as response variables in linear models that were compared using an information theoretic approach. Predictors were high/low parasitemias by Trypanosoma cruzi and T. evansi, and indices representing the abundance of distinct groups of gastrointestinal parasites. We also analyzed how host health changed with host sex and reproductive seasonality. Hemoparasites was best related to coati body condition and hematological indices, whereas abundance of gastrointestinal parasites was relatively less associated with coati health. Additionally, some associations were best predicted by models that incorporated reproductive seasonality and host sex. Overall, we observed a lower health condition during the breeding season, when coatis are under reproductive stress and may be less able to handle infection. In addition, females seem to handle infection better than males. Body condition was lower in coatis with high parasitemias of T. evansi, especially during the reproductive season. Total red blood cell counts, packed cell volume, platelets and eosinophils were also lower in animals with high T. evansi parasitemias. Total white blood cell counts and mature neutrophils were lower in animals with high parasitemias for both Trypanosoma species, with neutrophils decreasing mainly during the reproductive season. Overall, decreases in hematological parameters of females with T. evansi high parasitemias were less evident. For T. cruzi, monocytes decreased in individuals with high parasitemias. High abundances of microfilariae in the bloodstream, and cestode eggs and coccidian oocysts in feces were also associated with coati blood parameters. This study shows the potential value of examining hematological parameters as an approach to better understand the ecological relevance of parasite-host interactions.

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Section: Discussionmentioning

confidence: 99%

Co-Infection and Wild Animal Health: Effects of Trypanosomatids and Gastrointestinal Parasites on Coatis of the Brazilian Pantanal

et al. 2015

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“…Many pathologic, nutritional or environmental factors were found to play a role in activating or inhibiting of specific elements in clotting system by their effects on platelet, and/or endothelial function (Taylor et al, 2000). Findings of present study were revealed on significant decreases in platelet count of T. evansi infected camels, which caused either by splenic sequestration (Da Silva et al, 2010) or extravascular destruction of circulating platelets by the mononuclear phagocytic system (Kipper et al, 2011). Also, it suggested that thrombocytopenia occurs where the surface proteins of Trypanosoma adhere to blood cells as platelets being more susceptible to phagocytosis in spleen and liver (Naessens, 2006;Bezie et al, 2014).…”

Section: Discussionmentioning

confidence: 50%

Detection and Bloody Profiles Evaluation of Naturally Infected Camels with Subclinical Trypanosoma evansi, Iraq

Al-Abedi¹,

Sray²,

Hussein³

et al. 2020

ATMPH

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The current study directs for detection the molecular-prevalence of Trypanosoma evansi in naturally subclinical infected camels by PCR assay, in addition to establishment a reference values for blood parameters of study animals. During of April to November/2018, the total results for testing 92 venous blood samples were revealed on 27.17% T. evansi positive camels. Among T. evansi infected camels, significant increases (P0.05) were detected in age factor at 1-4 years group; whereas, no significant variation (P>0.05) was showed between groups of areas and gender factors. Concerning to hematology, significant decreases were showed in total RBCs, Hb, and MCHC; with significant increases in MCV and MCH. For leukocytes, significant increases were showed in total WBCs and lymphocytes only. In serum-biochemical indices, significant decreases (P0.05) were observed in albumin, albumin/globulin ratio, as well as in glucose; and significant increases in AST, ALT, GGT, ALP, CK, total protein, and globulins; but neither in BUN nor total bilirubin. For serum-minerals, significant decrease and significant increase were recorded respectively in iron and phosphorus; however, no significant differences were detected in calcium, magnesium, sodium, and potassium. In clotting factors, the findings were revealed on significant decreases in platelet and fibrinogen concentration, with significant increases in ACT, Prt, and Aptt. However, MPV and PDW were appeared without significant variation.

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Clinical signs and histopathology of brain, spinal cord and muscle of the pelvic limb of rats experimentally infected with Trypanosoma evansi

Silva

Oliveira

Bertoncheli

et al. 2012

Pathology - Research and Practice

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Relationship between splenic sequestration and thrombocytopenia in Trypanosoma evansi infection in rats

Cited by 4 publications

References 11 publications

Co-Infection and Wild Animal Health: Effects of Trypanosomatids and Gastrointestinal Parasites on Coatis of the Brazilian Pantanal

Co-Infection and Wild Animal Health: Effects of Trypanosomatids and Gastrointestinal Parasites on Coatis of the Brazilian Pantanal

Detection and Bloody Profiles Evaluation of Naturally Infected Camels with Subclinical Trypanosoma evansi, Iraq

Clinical signs and histopathology of brain, spinal cord and muscle of the pelvic limb of rats experimentally infected with Trypanosoma evansi

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