Relationship between Serum Vitamin-A Concentration and Hepatic Stellate Cells in Cows with Fatty-liver Disease

Ogawa, Miki; Imai, Katsuyuki; Oikawa, Shin; Hosaka, Yoshinao Z.; Takehana, Kazushige

doi:10.12935/jvma1951.57.639

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that cows with fatty liver and low serum VA concentration exhibit a reduction in the size of cytoplasmic lipid droplets in stellate cells, and thickening of the BM underlying the sinusoidal endothelium [23]. In this study post-parturient VA concentration dropped significantly in the non-treated group, and the VA concentration in the treated group remained higher than in the non-treated group throughout the study period.…”

Section: Discussionmentioning

confidence: 42%

Effectiveness of Isoprothiolane in Preventing Fatty Liver in Dairy Cows

Minaguchi¹,

Miura²,

Oikawa³

et al. 2013

TOVSJ

View full text Add to dashboard Cite

Abstract:In this study, we evaluated the effectiveness of isoprothiolane in preventing fatty liver in dairy cows. Eight pregnant Holstein cows with high body condition scores were studied. Four cows were administered isoprothiolane via feed at 10 g/day/head from 21 days before delivery (treated group), while the remaining four cows received no treatment (non-treated group). Liver samples from both groups were obtained 21 days before delivery and 2 days following delivery. No accumulation of lipid droplets in hepatocytes was observed in any cows prior to delivery. Following delivery, the accumulation of lipid droplets in hepatocytes was significantly reduced in the treated group compared to the non-treated group. The number of mitochondria per unit area was also significantly smaller in the treated group than in the non-treated group. Blood and biochemical test results from cows in the treated group showed an increase in mGOT levels and stable intrahepatic ATP production. These results suggest that isoprothiolane treatment intensified beta-oxidation in liver mitochondria, thereby activating the TCA cycle and maintaining intrahepatic ATP production.

show abstract

Section: Discussionmentioning

confidence: 42%