Relationship between serum uric acid and cerebral white matter lesions in the elderly

Shih, Chia‐Ju; Chen, Ching-Yu; Wen, Chia-Hsien; Liu, Hon‐Man; Kuo, Hsu-Ko

doi:10.1016/j.numecd.2010.06.005

Cited by 17 publications

(15 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Uric acid is an important endogenous antioxidant, and it can prevent oxidative stress owing to its ability to eliminate reactive oxygen species [10,11]. Previous studies have proposed that uric acid has the ability of reducing oxidative stress and protecting nervous system [12,13]. Considering the protective effect of uric acid on nerves, the association between Alzheimer's disease and uric acid levels had gained great interest in recent years [14][15][16][17][18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Inverse Association Between Serum Uric Acid Levels and Alzheimer’s Disease Risk

Hou

et al. 2015

Mol Neurobiol

View full text Add to dashboard Cite

The association between Alzheimer's disease and uric acid levels had gained great interest in recent years, but there was still lack of definite evidence. A systematic review and meta-analysis of relevant studies was performed to comprehensively estimate the association. Relevant studies published before October 26, 2014, were searched in PubMed, Embase, and China Biology Medicine (CBM) databases. Study-specific data were combined using random-effects or fixed-effects models of meta-analysis according to between-study heterogeneity. Twenty-four studies (21 case-control and 3 cohort studies) were finally included into the meta-analysis. Those 21 case-control studies included a total of 1128 cases of Alzheimer's disease and 2498 controls without Alzheimer's disease. Those 3 cohort studies included a total of 7327 participants. Meta-analysis showed that patients with Alzheimer's disease had lower levels of uric acid than healthy controls (weighted mean difference (WMD) = -0.77 mg/dl, 95% CI -2.28 to -0.36, P = 0.0002). High serum uric acid levels were significantly associated with decreased risk of Alzheimer's disease (risk ratio (RR) = 0.66, 95% CI 0.52-0.85, P = 0.001). There was low risk of publication bias in the meta-analysis. There is an inverse association between serum uric acid levels and Alzheimer's disease. High serum uric acid level is a protective factor of Alzheimer's disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Inverse Association Between Serum Uric Acid Levels and Alzheimer’s Disease Risk

Hou

et al. 2015

Mol Neurobiol

View full text Add to dashboard Cite

show abstract

“…The capacity of UA accounts for more than one‐half of the free radical scavenging capacity in serum. However, there have been significant questions whether UA is neuroprotective as an antioxidant or neurotoxic as a pro‐oxidant . When serum UA levels are elevated to ≥4 mg/dL, this former antioxidant may become a pro‐oxidant .…”

Section: Discussionmentioning

confidence: 99%

“…Several studies reported the association between hyperuricemia with other cardiovascular risk factors such as hypertension, diabetes mellitus, systemic inflammation, and lipid abnormalities . Recent data also suggest that serum UA is positively associated with increased cerebral ischemia as indexed by WMH volume . Even mildly elevated serum UA is associated with increased WMH volume, particularly in older adults .…”

Section: Introductionmentioning

confidence: 99%

“…Serum UA had been linked to oxidative stress and atherosclerosis, which were regarded as the contributors to the development of brain ischemic change . Several studies reported the association between hyperuricemia with other cardiovascular risk factors such as hypertension, diabetes mellitus, systemic inflammation, and lipid abnormalities . Recent data also suggest that serum UA is positively associated with increased cerebral ischemia as indexed by WMH volume .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum Uric Acid Is Associated with Cerebral White Matter Hyperintensities in Patients with Acute Lacunar Infarction

Han

Song

Bushnell

et al. 2015

Journal of Neuroimaging

View full text Add to dashboard Cite

show abstract

“…Although one study found high levels of uric acid independently related to the presence of SBIs only in women, others found uric acid as a risk factor for WMHs only in men. 93,94 Oxidative processes on lipids and carbohydrates lead to the formation of reactive carbonyl species that transforms proteins on advanced glycation end products. The activation of the receptor of advanced glycation end product induces proinflammatory cytokines and free radicals that also activate the receptor, thereby enhancing endothelial damage.…”

Section: Other Blood Biomarkersmentioning

confidence: 99%

Blood and CSF biomarkers in brain subcortical ischemic vascular disease: Involved pathways and clinical applicability

Vilar-Bergua

Riba‐Llena

Nafría

et al. 2015

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Vascular dementia is the second most common type of dementia after Alzheimer's disease (AD). Subcortical ischemic vascular disease refers to a form of vascular cognitive impairment characterized by the presence of diffuse white matter hyperintensities (WMHs) and multiple lacunar infarcts. These neuroimaging findings are mainly caused by cerebral smallvessel disease (cSVD) and relate to aging and cognitive impairment, but they can also be silent and highly prevalent in otherwise healthy individuals. We aimed to review studies on blood and cerebrospinal fluid (CSF) markers related to the presence of WMHs and lacunar infarcts that have been conducted in the past in large population-based studies and in high-risk selected patients (such as those with vascular risk factors, vascular cognitive impairment, or AD). Relevant associations with the presence and progression of cSVD have been described in the blood for markers related to inflammatory processes, endothelial damage and coagulation/fibrinolysis processes, etc. Also, different combinations of CSF markers might help to differentiate between etiologic types of dementia. In the future, to translate these findings into clinical practice and use biomarkers to early diagnosis and monitoring vascular cognitive impairment would require the replication of candidate markers in large-scale, multicenter, and prospectively designed studies.

show abstract

Relationship between serum uric acid and cerebral white matter lesions in the elderly

Cited by 17 publications

References 25 publications

Inverse Association Between Serum Uric Acid Levels and Alzheimer’s Disease Risk

Inverse Association Between Serum Uric Acid Levels and Alzheimer’s Disease Risk

Serum Uric Acid Is Associated with Cerebral White Matter Hyperintensities in Patients with Acute Lacunar Infarction

Blood and CSF biomarkers in brain subcortical ischemic vascular disease: Involved pathways and clinical applicability

Contact Info

Product

Resources

About