Inverse Association Between Serum Uric Acid Levels and Alzheimer’s Disease Risk

Du, Na; Xu, Dongmei; Hou, Xu; Song, Xuejia; Liu, Cancan; Chen, Ying; Wang, Yangang; Li, Xin

doi:10.1007/s12035-015-9271-6

Cited by 79 publications

(52 citation statements)

References 42 publications

(85 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…65 84 Discordance in the statistical significance was present for two outcomes: diabetic neuropathy (n=2) 51 53 and Alzheimer's disease (n=4). 57 58 73 80 After removing the overlapping meta-analyses (which were conducted in the same population for the same outcome), 76 unique meta-analyses were retained. The meta-analyses reported a wide range of outcomes (table 1): cardiovascular outcomes (n=13), diabetes related outcomes (n=9), kidney disorders (n=7), neurocognitive disorders (n=11), cancer outcomes (n=6), all cause or cause specific mortality (n=22), and other outcomes (n=8).…”

Section: Meta-analyses Of Observational Studiesmentioning

confidence: 99%

Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies

Meng

Timofeeva

et al. 2017

BMJ

273

232

View full text Add to dashboard Cite

Objective To map the diverse health outcomes associated with serum uric acid (SUA) levels. Design Umbrella review. Data sources Medline, Embase, Cochrane Database of Systematic Reviews, and screening of citations and references. Eligibility criteria Systematic reviews and meta-analyses of observational studies that examined associations between SUA level and health outcomes, meta-analyses of randomised controlled trials that investigated health outcomes related to SUA lowering treatment, and Mendelian randomisation studies that explored the causal associations of SUA level with health outcomes. Results 57 articles reporting 15 systematic reviews and144 meta-analyses of observational studies (76 unique outcomes), 8 articles reporting 31 meta-analyses of randomised controlled trials (20 unique outcomes), and 36 articles reporting 107 Mendelian randomisation studies (56 unique outcomes) met the eligibility criteria. Across all three study types, 136 unique health outcomes were reported. 16 unique outcomes in meta-analyses of observational studies had P<10-6, 8 unique outcomes in meta-analyses of randomised controlled trials had P<0.001, and 4 unique outcomes in Mendelian randomisation studies had P<0.01. Large between study heterogeneity was common (80% and 45% in meta-analyses of observational studies and of randomised controlled trials, respectively). 42 (55%) meta-analyses of observational studies and 7 (35%) meta-analyses of randomised controlled trials showed evidence of small study effects or excess significance bias. No associations from meta-analyses of observational studies were classified as convincing; five associations were classified as highly suggestive (increased risk of heart failure, hypertension, impaired fasting glucose or diabetes, chronic kidney disease, coronary heart disease mortality with high SUA levels). Only one outcome from randomised controlled trials (decreased risk of nephrolithiasis recurrence with SUA lowering treatment) had P<0.001, a 95% prediction interval excluding the null, and no large heterogeneity or bias. Only one outcome from Mendelian randomisation studies (increased risk of gout with high SUA levels) presented convincing evidence. Hypertension and chronic kidney disease showed concordant evidence in meta-analyses of observational studies, and in some (but not all) meta-analyses of randomised controlled trials with respective intermediate or surrogate outcomes, but they were not statistically significant in Mendelian randomisation studies. Conclusion Despite a few hundred systematic reviews, meta-analyses, and Mendelian randomisation studies exploring 136 unique health outcomes, convincing evidence of a clear role of SUA level only exists for gout and nephrolithiasis.

show abstract

Section: Meta-analyses Of Observational Studiesmentioning

confidence: 99%

Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies

Meng

Timofeeva

et al. 2017

BMJ

273

232

View full text Add to dashboard Cite

show abstract

“…Previous epidemiological studies proved that decreased uric acid levels were associated with an increased risk of PD and AD 23 , 24 . UA has the ability to reduce oxidative stress, to inhibit glutamate toxicity, and to protect central nervous system 8 , 25 .…”

Section: Discussionmentioning

confidence: 98%

Serum uric acid levels in patients with amyotrophic lateral sclerosis: a meta-analysis

Zhang

et al. 2018

Sci Rep

View full text Add to dashboard Cite

The pathogenic mechanism of ALS remains unclear. However, increasing evidence has indicated that uric acid (UA) may play a protective role in the pathogenesis of ALS. The aim of this study was to evaluate the association between serum UA levels and ALS. A comprehensive literature search in PubMed, Embase, Web of Science, and Cochrane Library was conducted up to 31st August, 2017, using keywords. A random-effects model or fixed-effects model was used to calculate the pooled estimate according to the inter-group heterogeneity. Finally, we indentified 8 case-control and 3 cohort studies. The results indicated that patients with ALS had significant decreased levels of serum UA compared to healthy controls (standardized mean difference (SMD) = −0.72, 95% CI [−0.98,−0.46], P < 0.001). Increased serum UA levels were associated with lower all-cause mortality risk among ALS patients (risk ratio (RR) = 0.70, 95% CI [0.57, 0.87], P = 0.001). To summarize, there is an inverse association between serum UA levels and risk of death among ALS patients. Randomized controlled trials with high quality are required to elucidate the role of UA on ALS.

show abstract

“…Increasing numbers of studies have found that uric acid plays an important role in cognitive impairment. 6 – 10 A relationship between uric acid and cognitive function has been demonstrated, and studies have investigated the association between uric acid and cognitive dysfunction in the context-specific diseases and various types of dementia. However, the relationship between uric acid and MCI has seldom been studied.…”

Section: Introductionmentioning

confidence: 99%

Low uric acid is a risk factor in mild cognitive impairment

Xue¹,

Liu²,

Xue³

et al. 2017

NDT

View full text Add to dashboard Cite

BackgroundMild cognitive impairment (MCI) represents a transitional stage between normal aging and dementia. Uric acid is a water-soluble antioxidant found in the body. Many recent studies have found that uric acid plays an important role in cognitive impairment, although the effects of uric acid on MCI are not clear.ObjectiveThe objective of this study was to explore the relationship between uric acid and MCI.MethodsUsing a random sampling method, this study investigated 58 patients with MCI and 57 healthy elderly from January 2016 to November 2016. Demographic information was collected, the subjects were evaluated using the Mini Mental Status Examination (MMSE), and uric acid was measured in fasting venous blood.ResultsA total of 57 (49.6%) participants are healthy and 58 (50.4%) participants had MCI. The uric acid level was significantly lower in the patients with MCI (292.28±63.71 μmol/L) than in the normal controls (322.49±78.70 μmol/L; P<0.05). There were significant positive correlations between the MMSE scores, for each dimension and the total score, and uric acid level (all P<0.05). Multivariate logistic regression models illustrated that uric acid was a protective factor for MCI (odds ratio =0.999, 95% CI =0.987–0.999).ConclusionA low uric acid level is a risk factor for MCI, and an appropriate increase in uric acid can be used to slow down the occurrence and development of MCI.

show abstract

Inverse Association Between Serum Uric Acid Levels and Alzheimer’s Disease Risk

Cited by 79 publications

References 42 publications

Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies

Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies

Serum uric acid levels in patients with amyotrophic lateral sclerosis: a meta-analysis

Low uric acid is a risk factor in mild cognitive impairment

Contact Info

Product

Resources

About