Relationship between serum magnesium and parathyroid hormone levels in hemodialysis patients

Navarro, Juan F.; Mora, Carmen; Jiménez, Alejandro; Torres, Armando; Macía, Manuel; Garcia, J.

doi:10.1016/s0272-6386(99)70106-x

Cited by 84 publications

(79 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was reported that hypermagnesemia decreased PTH concentration in the serum of goat [39] and rat [13]. Also, it was reported that there is a significant negative relationship between PTH and Mg concentrations in the blood of hemodialysis patients not receiving vitamin D 3 [29]. Further, it was reported that an increase in dietary Mg decreased plasma PTH concentration in rat [13].…”

Section: Discussionmentioning

confidence: 99%

Dietary magnesium increases calcium absorption of ovine small intestine in vivo and in vitro

et al. 2002

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Dietary magnesium increases calcium absorption of ovine small intestine in vivo and in vitro

et al. 2002

View full text Add to dashboard Cite

“…Consistent with above-mentioned studies, Navarro et al also detected an inverse correlation of serum Mg with PTH levels. The study conducted on 110 hemodialysis individuals with mean age of 55 ± 14 years and the duration of dialysis was 35 ± 28 months (14). To find association of serum PTH and Mg levels in continuous ambulatory peritoneal dialysis subjects using low-Mg peritoneal dialysate, Cho et al detected that parathormone level was not associated with serum Mg level.…”

Section: Discussionmentioning

confidence: 99%

Serum magnesium in association with parathyroid hormone levels in routine hemodialysis patients

Fooladgar¹,

Malekpour²,

Asgari-Savadjani³

et al. 2017

J Parathyr Dis

View full text Add to dashboard Cite

Introduction: The homeostasis of magnesium (Mg) is perturbed in chronic kidney disease. It has been supposed that plasma Mg has a principal role to regulate the secretion of parathyroid hormone (PTH). Plasma Mg is capable of modulating secretion of PTH. Recent investigations showed that low serum Mg levels in patients with kidney disease have been linked to increased mortality. Objectives: The aim of this study was to determine the relationship between serum Mg and PTH levels in hemodialysis patients. Patients and Methods:This cross-sectional study was conducted on 56 hemodialysis patients in hemodialysis center of Hajar hospital of Shahrekord in 2015. Regular hemodialysis patients who had at least three months history of dialysis were enrolled to the study. The serum levels of Mg, calcium, phosphorus, intact PTH (iPTH), alkaline phosphatase, albumin and bicarbonate were measured. Results: In this study, 61.5% of the 52 patients were male. Mean ± standard deviation (SD) of patients' age was 60.5 ± 17.7 years with median of 63 years old. The average duration of dialysis was 44±39.5 months (median 36 months). Additionally the dialysis dose was 517 ± 479 weeks (median; 414 weeks). Mean ± SD of serum iPTH and Mg were 360.1 ± 238.2 pg/mL and 2.2 ± 0.2 mg/mL respectively. In this study we found a significantly positive correlation of iPTH with serum Mg levels (r = 0.28, P = 0.04). Conclusion: This study shows impact of Mg on parathormone secretion. Our findings require further investigations with larger and multicentric studies. Please cite this paper as: Fooladgar M, Malekpour A, Asgari-Savadjani S, Mardani S. Serum magnesium in association with parathyroid hormone levels in routine hemodialysis patients. J Parathyr Dis. 2018;6(1):13-15.

show abstract

“…In our study, unlike other reports, we found that there was no inverse relationship between serum Mg and PTH. 18,[39][40][41] One of the reasons for the difference might be sample differentia. The patients who are included had severe secondary hyperparathyroidism with PTH4500 pg/mL and unmanageable parathyroid hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

Effect of parathyroid hormone on serum magnesium levels: the neglected relationship in hemodialysis patients with secondary hyperparathyroidism

Teng

Hou

et al. 2015

Renal Failure

View full text Add to dashboard Cite

disturbance plays an important role in CKD-MBD and cardiovascular mortality, the interest on magnesium has grown recently. Although much concern focused on the effect of Mg on parathyroid hormone (PTH) levels, however, the influence of PTH on serum Mg levels is nearly unexplored. To evaluate the effect of PTH on serum Mg levels, we first described the relationship between serum Mg and PTH in secondary hyperparathyroidism. Besides, we also monitored the changes of serum Mg concentration after parathyroidectomy (PTX) in 23 patients. In our study, we found that hypermagnesemia (42.5 mg/dL) occurred in up to 44% of cases and hypomagnesemia did not present. No statistically signiEcant correlations were found between serum Mg levels and PTH (r ¼ À0.143, p ¼ 0.134). Correlation analysis and regression analysis suggested that the derangement of magnesium homeostasis was consistent with the derangement of calcium/phosphorus homeostasis. However, after PTX, serum magnesium levels dropped immediately after the surgery, minimally at the first day and gradually restored from the third day. The changes of serum Mg after surgery was positive correlated with the changes of serum phosphate (r ¼ 0.558, p ¼ 0.003). Taken altogether, our data suggested that the therapeutic strategies to achieve optimum serum magnesium levels in CKD-MBD should take into account the varying stages of disease development since PTH could also influence magnesium metabolism and this problem might be important in severe secondary hyperparathyroidism. KeywordsSerum magnesium, parathyroid hormone, secondary hyperparathyroidism, chronic kidney disease-mineral and bone disorder, parathyroidectomy History

show abstract

Relationship between serum magnesium and parathyroid hormone levels in hemodialysis patients

Cited by 84 publications

References 36 publications

Dietary magnesium increases calcium absorption of ovine small intestine in vivo and in vitro

Dietary magnesium increases calcium absorption of ovine small intestine in vivo and in vitro

Serum magnesium in association with parathyroid hormone levels in routine hemodialysis patients

Effect of parathyroid hormone on serum magnesium levels: the neglected relationship in hemodialysis patients with secondary hyperparathyroidism

Contact Info

Product

Resources

About