Relationship between Serum Levels of Body Iron Parameters and Insulin Resistance and Metabolic Syndrome in Korean Children

Lee, Hye-Ja; Jang, Han Byul; Park, Ji Eun; Park, Kyung-Hee; Kang, Jae Heon; Park, Sang Ick; Song, Jihyun

doi:10.1016/j.phrp.2014.06.005

Cited by 18 publications

(24 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found the highest level of iron in group of healthy animals receiving SAE, while increased level of iron was found in all groups with MetS compared to healthy rats. Previous study indicates that increased iron stores have been associated with MetS [36]. Changing dietary habits from high-fat to standard food did not result in change of iron, while addition of SAE in this group induced significant rise when compared to MetS group.…”

Section: Discussionmentioning

confidence: 59%

Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model

Jakovljević

Milić²,

Bradić

et al. 2018

IJMS

View full text Add to dashboard Cite

The aim of our study was to examine the effects of different dietary strategies, high-fat (HFd) or standard diet (Sd) alone or in combination with standardized oral supplementation (0.45 mL/kg/day) of Aronia melanocarpa extract (SAE) in rats with metabolic syndrome (MetS). SAE is an official product of pharmaceutical company Pharmanova (Belgrade, Serbia); however, the procedure for extraction was done by EU-Chem company (Belgrade, Serbia). Rats were divided randomly into six groups: control with Sd, control with Sd and SAE, MetS with HFd, MetS with HFd and SAE, MetS with Sd and MetS with Sd and SAE during 4 weeks. At the end of the 4-week protocol, cardiac function and liver morphology were assessed, while in the blood samples glucose, insulin, iron levels and systemic redox state were determined. Our results demonstrated that SAE had the ability to lower blood pressure and exert benefits on in vivo and ex vivo heart function. Moreover, SAE improved glucose tolerance, attenuated pathological liver alterations and oxidative stress present in MetS. Obtained beneficial effects of SAE were more prominent in combination with changing dietary habits. Promising potential of SAE supplementation alone or in combination with different dietary protocols in triggering cardioprotection should be further examined in future.

show abstract

Section: Discussionmentioning

confidence: 59%

Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model

Jakovljević

Milić²,

Bradić

et al. 2018

IJMS

View full text Add to dashboard Cite

show abstract

“…Several studies have examined sTfR levels in subjects with metabolic syndrome, but their results are quite inconsistent [11, 28–30]. In addition, a meta-analysis of prospective studies demonstrated a negative relationship between transferrin saturation and cardiovascular events such as coronary heart disease and acute myocardial infarction [31].…”

Section: Discussionmentioning

confidence: 99%

Iron metabolism and its association with dyslipidemia risk in children and adolescents: a cross-sectional study

Zhu

Xiao

et al. 2019

Lipids Health Dis

View full text Add to dashboard Cite

BackgroundInformation on the association between iron metabolism and dyslipidaemia in children is limited. Thus, this study aims to evaluate the iron metabolic status of children with different body mass index (BMI) and to examine the association between iron metabolism and dyslipidaemia risk.MethodIn total, 1866 children and adolescents aged 7–18 were enrolled in this study, including 912 boys and 954 girls. In this cross-sectional study, parameters for anthropometry, lipids and iron metabolism including transferrin, soluble transferrin receptor (sTfR), ferritin and serum iron (SF) were evaluated. Data regarding demographic characteristics, diet, and physical activity were collected by self-reported questionnaires.ResultsThe prevalence of dyslipidaemia and iron deficiency in children and adolescents increased based on BMI categories (both P < 0.05) and were 58.3 and 8.9% in subjects with obesity, respectively. The lowest SF and the highest ferritin levels were observed in subjects who were obese (both P < 0.001). Subjects with dyslipidaemia had lower SF, transferrin and sTfR levels by different BMI categories, and those who were obese had higher ferritin levels (all P < 0.05). Most importantly, higher concentrations of transferrin and sTfR were related to lower dyslipidaemia risk (OR for transferrin: 0.49, 95% CI: 0.33–0.71; OR for sTfR: 0.68, 95% CI: 0.46–0.99).ConclusionsA downward trend in SF level by BMI categories and the highest ferritin level in subjects with obesity suggested that iron storage was associated with BMI in children and adolescents. Moreover, an inverse relationship was observed between transferrin and sTfR concentrations and dyslipidaemia risk in children with different BMI.

show abstract

“…Although some large cross-sectional studies have suggested an association between ferritin levels, and dyslipidemia and some metabolic diseases, few studies have focused on adolescents. Recently, Lee et al reported that children in a group with high HOMA-IR had greater total iron-binding capacity and serum transferrin levels, and were more likely to develop MS, butthey could not demonstrate an association between serum ferritin levels and dyslipidemia parameters [ 40 ]. A study byJeon et al also examined dyslipidemia parameters in Korean adolescents, and observed a link between serum ferritin levels and obesity, but not between serum ferritin levels and MS components [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Serum Ferritin Levels and Dyslipidemia in Korean Adolescents

Kim

Roh

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

BackgroundFerritin is associated with various cardiometabolic risk factors such as dyslipidemia, hypertension, obesity, and insulin resistance in adults. We aimed to study the association between serum ferritin levels and dyslipidemia in adolescents, because dyslipidemia is considered an important modifiable cardiovascular risk factor in the young.MethodsWe analyzed 1,879 subjects (1,026 boys and 853 girls) from the 2009–2010 Korean National Health and Nutrition Examination Survey IV. Subjects were categorized into quartiles according to their lipid parameters, which were classified according to age and gender. Those in the highest quartile groups for total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglyceride concentrations were diagnosed as having dyslipidemia. Those in the lowest quartile for high-density lipoprotein cholesterol (HDL-C) values were diagnosed with abnormal levels.ResultsIn boys, total cholesterol, LDL-C, and triglyceride concentrations were significantly correlated with serum ferritin levels. In both boys and girls, serum ferritin levels were negatively associated with HDL-C values, even after adjusting for all covariates. Furthermore, there was no significant correlation between serum ferritin levels and total cholesterol, LDL, and triglyceride concentrations in girls.ConclusionSerum ferritin levels were significantly associated with major dyslipidemia parameters, more prominently in boys than in girls, and this association represents a cardiometabolic risk factor.

show abstract

Relationship between Serum Levels of Body Iron Parameters and Insulin Resistance and Metabolic Syndrome in Korean Children

Cited by 18 publications

References 29 publications

Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model

Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model

Iron metabolism and its association with dyslipidemia risk in children and adolescents: a cross-sectional study

Relationship between Serum Ferritin Levels and Dyslipidemia in Korean Adolescents

Contact Info

Product

Resources

About