Relationship between Serum Ferritin Levels and Dyslipidemia in Korean Adolescents

Kim, Young Eun; Kim, Do Hoon; Roh, Yong Kyun; Ju, Sang Yhun; Yoon, Yeo Joon; Nam, Ga Eun; Nam, Hyo Yun; Choi, Jin Kyeong; Lee, Jong Eun; Sang, Jung Eun; Han, Kyungdo; Park, Yong Gyu

doi:10.1371/journal.pone.0153167

Cited by 24 publications

(41 citation statements)

References 45 publications

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“…Previous studies debated on the associations between high SF and dyslipidemic parameters among participants of different ages, sexes, body sizes and ethnic distributions. Kim et al found that in Korean adolescents, SF was positively correlated with TC, TG, and LDL-C levels only in boys, but negatively correlated with HDL-C in both boys and girls [44]. In a Finnish study of adults, SF was shown to be correlated with markers of cardiometabolic risk (elevated TG, apoB, and reduced HDL-C) [45].…”

Section: Discussionmentioning

confidence: 99%

Associations of iron status with apolipoproteins and lipid ratios: a cross-sectional study from the China Health and Nutrition Survey

Zhou¹,

Ren²,

Zhou³

et al. 2020

Lipids Health Dis

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Background: Iron overload has been found to be related with various cardiometabolic disorders, like dyslipidemia, metabolic syndrome, and diabetes. The disturbance of the iron status and lipid metabolism can contribute to organ damage such as atherosclerotic plaque growth and instability. An assessment on the associations of iron status with apolipoproteins and lipid ratios would be informative for maintenance of metabolic homeostasis and hinderance of disease progression. Hence, this study aims to establish the relationships of iron status with apolipoproteins and lipid ratios. Methods: A cross-sectional study of 7540 adult participants from the China Health and Nutrition Survey 2009 was conducted. Logistic regression analyses were used to investigate the relationships between indicators of iron status and the prevalence of unfavorable apolipoprotein profiles. Multivariate linear regression models were constructed to assess the dose-response correlations between serum ferritin and lipid parameters. Results: After adjustment for confounding factors, in both sexes, the subjects in the top quartile of ferritin had the highest prevalence of an elevated apolipoprotein B (men: odds ratio (OR) 1.97, 95% confidence interval (CI) 1.50-2.62; women: OR 2.13, 95% CI 1.53-2.97) and an elevated apolipoprotein B/apolipoprotein A1 ratio (men: OR 2.00, 95% CI 1.50-2.66; women: OR 1.41, 95% CI 1.04-1.92) when compared with individuals in the lowest quartile. Hemoglobin were also independently associated with unfavorable apolipoprotein B and apolipoprotein B/ apolipoprotein A1 ratio both in men and women. However, transferrin (men: OR 0.74, 95% CI 0.56-0.99; women: OR 0.73, 95% CI 0.56-0.95) and soluble transferrin receptor (men: OR 0.75, 95% CI 0.57-0.99; women: OR 0.71, 95% CI 0.55-0.91) were found to be negatively associated with a decreased apolipoprotein A1. Moreover, after controlling for potential confounders, the ferritin concentrations were significantly associated with the levels of lipid ratios including TG/HDL

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Section: Discussionmentioning

confidence: 99%

Associations of iron status with apolipoproteins and lipid ratios: a cross-sectional study from the China Health and Nutrition Survey

Zhou¹,

Ren²,

Zhou³

et al. 2020

Lipids Health Dis

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“…Recently, we reported that ferritin levels are associated with metabolic syndrome in children and adolescents [ 4 ]. In adults, ferritin levels are independently associated with a high prevalence of dyslipidemia [ 5 ], non-alcoholic fatty liver disease [ 6 ], insulin resistance [ 7 ], and stroke [ 8 ]. In addition, some studies have suggested that SF also has a role in the development of central obesity [ 9 ], hypertension [ 10 ], type 2 diabetes mellitus [ 11 ], and coronary artery disease [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Reference values for serum ferritin and percentage of transferrin saturation in Korean children and adolescents

Oh¹,

Lee²,

Kim³

et al. 2018

Blood Res

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BackgroundFerritin reference values vary by age, gender, and ethnicity. We aimed to determine reference values of serum ferritin (SF) and the percentage of transferrin saturation (TSAT) for Korean children and adolescents.MethodsWe analyzed data from 2,487 participants (1,311 males and 1,176 females) aged 10–20 years from the Korea National Health and Nutrition Examination Survey (2010–2012). We calculated age- and gender-stratified means and percentile values for SF and TSAT.ResultsWe first plotted mean SF and TSAT by gender and according to age. In males, mean SF tended to be relatively constant among participants aged 10 to 14 years, with an upward trend thereafter. Mean SF trended downward among female participants until the age of 15 years and remained constant thereafter. Thus, significant gender differences in ferritin exist from the age of 14 years. High levels of SF were associated with obesity, and lower SF levels were associated with anemia and menarche status.ConclusionWe established reference values of SF and TSAT according to age and gender. The reference values for SF calculated in this study can be used to test the association between SF values and other defined diseases in Korean children and adolescents.

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“…3 Apart from these effects, the recent research suggests that raised ferritin levels in the body is also associated with metabolic derangements in the body. 9 Lipids are regarded as an important source of energy in the body. 10 They have a necessary role in signaling metabolites in body.…”

Section: Introductionmentioning

confidence: 99%

“…6 Sometimes, in certain hereditary conditions, the lipid profile may be deranged since childhood. 9 Unluckily, in such cases, it causes premature cardiovascular diseases in young age and is associated with poor prognosis. 9 The recent research and clinical data proposes that there is a link between regulatory processes of ferritin and lipids in the body.…”

Section: Introductionmentioning

confidence: 99%

“…9 Unluckily, in such cases, it causes premature cardiovascular diseases in young age and is associated with poor prognosis. 9 The recent research and clinical data proposes that there is a link between regulatory processes of ferritin and lipids in the body. 1 So, the disruption or abnormality of metabolic pathways of ferritin causes the disruption of that of lipids too.…”

Section: Introductionmentioning

confidence: 99%

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Correlation between levels of serum ferritin and lipid profile status.

Rahman

Khan

Rahman

et al. 2020

TPMJ

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Objectives: To analyse the correlation between ferritin level in serum and lipid profile in patients presenting to a Tertiary Care Centre. Study Design: Cross Sectional Descriptive study. Setting: Khyber Teaching Hospital Peshawar. Period: 1st January 2019 to 31st July 2019. Material & Methods: About 60 patients presenting to the laboratory referred for serum lipid profile or serum ferritin were included in the study. Sampling was done by purposive non probability technique. Blood was taken from patients in gel tube. Serum ferritin levels and lipid profile were done in all cases. Lipid profile included serum cholesterol, triglyceride level, low density lipoprotein and high density lipoproteins. The levels were recorded in a proforma. The serum ferritin level was correlated with the lipid profile status in all patient and the results were drawn accordingly. Results: About 60 patients were analysed. The mean age was 20.8± 5.2 years (range: 2 years to 60 years). There were 39 (65%) males and 21(35%) females. Out of 60 cases, serum ferritin level was normal, increased and lower in 15(25%), 40(66.6%) and 5 (8.3%) cases respectively. The cases where serum ferritin was abnormally raised, the significant changes in lipid profile were raised cholesterol and raised triglyceride (in 62.5% and 82.5% cases respectively). Conclusion: There is an association between raised serum ferritin and raised serum cholesterol level and serum triglyceride levels. This supports the link between serum ferritin regulation and lipid metabolism in the body. As dyslipidemia is a major cardiovascular risk factor. Therefore, a raised ferritin level must alert the physician about lipid profile of the patient and should prompt the physician to think about preventive measures against cardiovascular events in order to decrease the morbidity and mortality in patients at risk.

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Relationship between Serum Ferritin Levels and Dyslipidemia in Korean Adolescents

Cited by 24 publications

References 45 publications

Associations of iron status with apolipoproteins and lipid ratios: a cross-sectional study from the China Health and Nutrition Survey

Associations of iron status with apolipoproteins and lipid ratios: a cross-sectional study from the China Health and Nutrition Survey

Reference values for serum ferritin and percentage of transferrin saturation in Korean children and adolescents

Correlation between levels of serum ferritin and lipid profile status.

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