Relationship between serum leptin and insulin resistance among obese Nigerian women

Osegbe, Ifeyinwa; Okpara, Henry Chima; Azinge, Elaine Chinyelu

doi:10.4103/1596-3519.158524

Cited by 57 publications

(44 citation statements)

References 28 publications

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“…At the same time, there are publications showing that prolonged hyperleptinemia inhibits the expression of insulin mRNA, which may ultimately serve as a trigger of hyperglycemia and IR 24 . Osegbe et al (2016) have found a positive correlation between the level of leptin and the severity of IR in females with different BMI values 25 . Leptin may also inhibit insulin receptor signal through activation of the suppressor of cytokine signal type 3 26 .…”

Section: Discussionmentioning

confidence: 98%

The role of multiple regression analysis in prediction of insulin resistance in overweight and obese children

Pavlyshyn¹

2019

Arch Balk Med Union

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Le rôle de l'analyse de régression multiple dans la prédiction de la résistance à l'insuline chez les enfants avec surpoids et obèses Introduction. L'excédent de poids et l'obésité constituent une épidémie à l'échelle mondiale chez les enfants de tous les groupes d'âge. Les enfants obèses présentent un risque accru de résistance à l'insuline, de maladies cardiovasculaires (y compris l'hypertension), de fractures osseuses et de problèmes psychologiques. À cet égard, la résistance à l'insuline est devenue l'un des problèmes de santé les plus graves chez les enfants avec surpoids et obèses. L'objectif de l'étude était d'étudier les traits spécifiques du métabolisme des glucides chez les enfants avec surpoids et obèses, d'identifier les facteurs clés de la résistance à l'insuline et de développer un modèle pronostique basé sur une analyse de régression pour prédire son occurrence. Matériels et méthodes. Des mesures anthropométriques, la collecte de données sur l'histoire et des examens de laboratoire ont été effectués chez 90 enfants obèses et 20 enfants avec surpoids de 10 à 17 ans. L'analyse de régression multiple a été utilisée pour ABSTRACT Introduction. Overweight and obesity is a global epidemic among children of all age groups. Obese children are at increased risk of insulin resistance, cardiovascular disease (including arterial hypertension), as well as bone fractures and psychological problems. In this regard, insulin resistance has become one of the most serious health concerns in overweight and obese children. The objective of the study was to investigate the specifics for carbohydrate metabolism in overweight and obese children, to identify the key factors for insulin resistance and to develop a regression analysis-based prognostic model to predict its occurrence. Material and methods. In 90 obese and 20 overweight children aged between 10-17 years, anthropometric measurements, history data collection and laboratory investigations were performed. Multiple regression analysis has been used to develop a mathematical model for prediction of insulin resistance. Results. Such variables as weight, body mass index, waist and hip circumferences, abdominal type obesity, family history, duration of breastfeeding (if any), birth weight, sedentary lifestyle, leptin and adiponectin levels and dyslipidemia were closely related to fasting glucose levels and insulin/insulin resistance indices.

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Section: Discussionmentioning

confidence: 98%

The role of multiple regression analysis in prediction of insulin resistance in overweight and obese children

Pavlyshyn¹

2019

Arch Balk Med Union

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“…As inflammation induces central leptin resistance, leptin is an important link between obesity and HPG axis defects [137]. Interestingly, serum leptin levels are positively correlated with insulin resistance (IR) [138] raising the possibility that leptin is also involved in regulating IR. Indeed, leptin regulates insulin receptor substrate-1 and 2 (IRS-1, IRS2) [139], modulates glucose metabolism and the function of insulin producing pancreatic β-cells [140].…”

Section: Pathophysiological Consequences: Effect Of Obesity-induced Imentioning

confidence: 99%

Effect of Inflammation on Female Gonadotropin-Releasing Hormone (GnRH) Neurons: Mechanisms and Consequences

Barabás

Szabó-Meleg

Ábrahám

2020

IJMS

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Inflammation has a well-known suppressive effect on fertility. The function of gonadotropin-releasing hormone (GnRH) neurons, the central regulator of fertility is substantially altered during inflammation in females. In our review we discuss the latest results on how the function of GnRH neurons is modified by inflammation in females. We first address the various effects of inflammation on GnRH neurons and their functional consequences. Second, we survey the possible mechanisms underlying the inflammation-induced actions on GnRH neurons. The role of several factors will be discerned in transmitting inflammatory signals to the GnRH neurons: cytokines, kisspeptin, RFamide-related peptides, estradiol and the anti-inflammatory cholinergic pathway. Since aging and obesity are both characterized by reproductive decline our review also focuses on the mechanisms and pathophysiological consequences of the impact of inflammation on GnRH neurons in aging and obesity.

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“…Leptin is called a "satiety hormone" because it regulates food intake and energy expenditure. It acts via leptin receptors which are found in the hypothalamus [1,21]. Its secretion is regulated, among others, by insulin and cortisol concentrations [22].…”

Section: Adipokines -Leptin and Adiponectinmentioning

confidence: 99%

Gestational diabetes mellitus — literature review on selected cytokines and hormones of confirmed or possible role in its pathogenesis

et al. 2018

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The incidence of gestational diabetes mellitus (GDM) increases globally, including Poland. Considering serious consequences of gestational diabetes for both mother and fetus, screening for this disorder is an obligatory element of managing pregnant woman. The pathogenesis of gestational diabetes is not yet thoroughly explained. However, it is insulin resistance and chronic subclinical inflammatory process which are considered to be major factors responsible for the development of GDM. These two states are triggered mainly by secretion of proinflammatory cytokines and by abnormal function of adipose tissue. The study reviews the literature on selected hormones and cytokines whose role in the GDM pathogenesis has been already confirmed as well as on those proteins whose role is either not yet fully understood or which may possibly participate in GDM development. Owing to the fact that underlying mechanisms of GDM are, in general, similar to the mechanisms responsible for metabolic disorders such as diabetes mellitus type 2 or obesity, in this review we focus first on the role these molecules play in pathogenesis of metabolic disorders and then present current state of knowledge on their action in gestational diabetes development. The review presents: TNF alpha, adipokines-adiponectin and leptin and relatively newly discovered proteins: fetuin A, periostin, angiopoietin-like protein 8 or high mobility group box.

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Relationship between serum leptin and insulin resistance among obese Nigerian women

Cited by 57 publications

References 28 publications

The role of multiple regression analysis in prediction of insulin resistance in overweight and obese children

The role of multiple regression analysis in prediction of insulin resistance in overweight and obese children

Effect of Inflammation on Female Gonadotropin-Releasing Hormone (GnRH) Neurons: Mechanisms and Consequences

Gestational diabetes mellitus — literature review on selected cytokines and hormones of confirmed or possible role in its pathogenesis

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