Relationship between serum erythropoietin levels and rT3, T4 concentrations in elderly patients with non-thyroidal illnesses

Corica, Francesco; Allegra, Alessandro; Buemi, Michele; Castagna, Laura; Corsonello, Andrea; Benedetto, A. Di; Cotroneo, Antonella; Cucinotta, G.; Cincotta, Maria; Ceruso, D

doi:10.1016/0167-4943(96)86981-0

Cited by 2 publications

(1 citation statement)

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“…Several authors have indicated TNF-a, IL-1, IL-6, and acid and basic fibroblast growth factor as putative mediators of the modifications in thyroid function observed in NTI patients (6)(7)(8)(9). Elsewhere we reported on the links between the low T 3 syndrome and erythropoietin and TNF-a plasma concentrations in NTI patients (10).…”

Section: Introductionmentioning

confidence: 91%

Increased transforming growth factor-beta1 plasma concentration is associated with high plasma 3,3',5'-tri-iodothyronine in elderly patients with nonthyroidal illnesses

Corica

Allegra

Corsonello

et al. 1998

European Journal of Endocrinology

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Objective: To study transforming growth factor-b1 (TGF-b1) plasma concentrations in elderly patients with nonthyroidal illnesses (NTI). Design: Case-control study. Methods: We measured plasma concentrations of tri-iodothyronine (T 3 ), reverse T 3 (rT 3 ), thyroxine (T 4 ), free T 3 (fT 3 ) and free T 4 (fT 4 ) estimates, TSH, and TGF-b1 in 48 elderly NTI patients consecutively admitted in our Division of Internal Medicine and Metabolic Diseases, and in 11 healthy age-and sexmatched controls. Results: The data on thyroid hormones enabled us to identify three groups: Group A, subjects (8 patients) with T 3 and fT 3 levels comparable to those in controls; Group B, subjects (30 patients) with T 3 and fT 3 levels lower than controls but rT 3 levels comparable to those of controls; Group C, subjects (10 patients) with T 3 and fT 3 levels lower than those of controls and higher rT 3 levels. The patients of Group C showed higher plasma levels of TGF-b1 compared with controls. Moreover, we found a positive correlation between TGF-b1 and rT 3 (r S ¼ 0.38, P < 0.01) in the whole group of NTI patients. Conclusions: Our data seem to confirm the hypothesis that TGF-b1 could play a role in the pathogenesis of some modifications of thyroid function observed in patients with nonthyroidal illnesses.

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