Relationship between Serum 25OH-Vitamin D2 Level and Vitamin D Status of Children Aged 3–5 Years in China

Abstract

Background: Vitamin D deficiency is prevalent globally and there is lack of evidence as to how 25(OH)D2 contributes to vitamin D status. The aim of this study was to describe vitamin D status and to assess the role of vitamin D2, a dietary vitamin D source, against the vitamin D status of children aged 3–5 years in China. Methods: Data were extracted from the Chinese National Nutrition and Health Surveillance (CNNHS) in 2013. The concentration of serum 25(OH)D2 and 25(OH)D3 was measured by using LC-MS/MS. Results: A total of 1435 subjects were enrolled and serum 25(OH)D were analyzed. The prevalence of total serum 25(OH)D < 30 nmol/L was 8.9%. Serum 25(OH)D2 was detected in 10.9% of the studied children. After adjusting for confounding factors, total 25(OH)D concentration was 8.48 nmol/L lower and odds ratio of vitamin D deficiency was 4.20 times (OR (95%CI): 4.20 (1.64, 10.77)) in children without 25(OH)D2 than those with 25(OH)D2 detected. Conclusions: Vitamin D deficiency was common among children aged 3–5 years in China. Vitamin D2 may play a role in preventing vitamin D deficiency in Chinese children aged 3–5 years.

Systematic Literature Review of the Nutrient Status, Intake, and Diet Quality of Chinese Children across Different Age Groups

“…The decreasing Vitamin D concentration and increasing VDD with age are shown in Figure 4 [ 19 , 26 , 71 , 76 , 99 ] and Table 5 . National data from CHNS 2011-12 for children 6 to 17 years old reported VDD at 53% (48.2 (35.4–63.4) nmol/L) [ 34 ].…”

“… The Vitamin D concentration in Chinese children across different age groups [ 26 , 34 , 58 , 67 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 85 , 87 , 89 , 89 , 90 , 91 , 99 ]. The clinical practice guidelines of the Endocrine Society Task Force on Vitamin D have defined a cutoff level of <20 ng/mL (50 nmol/L) as Vitamin D deficient and levels between 20 and 30 ng/mL (50–75 nmol/L) as ‘insufficient’ [ 19 ].…”

Lifelong deformities in an adult caused by vitamin D‑dependent rickets type 1A: A case report

“…Whilst vitamin D3 is formed from the exposure of 7-dehydrocholesterol in the skin to ultraviolet B (280-310 nm) light. Vitamin D is metabolized and converted into its active form 1,25-dihydroxy-vitamin D3 [1,25(OH) 2 D] by several enzymes, mainly microsomal CYP2R1 in the liver and 25-OH vitamin D-1α-hydroxylase in kidneys, which promotes calcium absorption from the gut into the bloodstream and regulates serum calcium concentration maintained at 2.25 to 2.75 mmol/l. Deficiencies in vitamin D metabolism or action can cause hypocalcemia and high serum parathyroid hormone (PTH) levels (2).…”

“…Vitamin D exists as two main forms in the body: Vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol) ( 1 ). Vitamin D2 is derived from the diet, such as ryegrass, beef and lamb.…”

“…CAIHONG YI1 , JUAN XU 2 , JIANGPING HE 1 , XIAOFANG ZHANG 1 , XIANFENG ZHANG 2 and JIAO HUANG1 Departments of 1 Rheumatology and Immunology and 2 Endocrinology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, P.R. China…”