Relationship between sarcopenia and physical activity in older people: a systematic review and meta-analysis

Šteffl, Michal; Bohannon, Richard W.; Sontáková, Lenka; Tufano, James J.; Shiells, Kate; Holmerová, Iva

doi:10.2147/cia.s132940

Cited by 365 publications

(309 citation statements)

References 76 publications

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“…Our findings support previous research on the role of physical activity in preventing sarcopenia 6. The present study is one of the first to extend the beneficial influence of physical activity with longitudinal data.…”

Section: Discussionsupporting

confidence: 91%

“…Recent epidemiological studies support the role of physical activity as a protective factor against sarcopenia development, yet the basis of current evidence is cross-sectional or retrospective investigations 6. Moreover, only few investigations7 have considered gender-specific risk factors in sarcopenia, despite the clear difference in immune response homeostasis between men and women and subsequent disease risks in their ageing process 8…”

Section: Introductionmentioning

confidence: 99%

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Gender-specific risk factors for incident sarcopenia: 8-year follow-up of the English longitudinal study of ageing

Yang

Smıth

Hamer

2018

J Epidemiol Community Health

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BackgroundThe aetiology of age-related sarcopenia is not known.ObjectivesTo investigate if risk of developing sarcopenia differs by gender and to identify gender-specific risk factors of incident sarcopenia in a large population-based cohort of older English adults.MethodsThe sample (n=3404; age 63.4 (SD 7.7) years; 54.1% women) comprised older community-dwelling adults recruited from the English Longitudinal Study of Ageing. Sarcopenia was defined as handgrip <26 kg in men and <16 kg in women. Handgrip strength was assessed at baseline (2004/2005) and repeated at follow-up (2012/2013). Analysed risk factors included baseline anthropometric measures, smoking, vigorous and moderate physical activity, depressive symptoms, chronic illnesses and wealth. After excluding participants with sarcopenia at baseline, multivariable logistic regressions were used to explore baseline risk factors for incident sarcopenia.ResultsDuring 8-year follow-up, 208 and 287 cases of sarcopenia were identified in men (n=1564) and women (n=1840), respectively. Women were at 20% (age adjusted OR=1.20, 95% CI 0.98 to 1.47) higher risk of developing sarcopenia than men. The inverse association between physical activity and sarcopenia risk was observed at moderate (OR=0.44, 95% CI 0.27 to 0.67) and vigorous (0.53, 95% CI 0.31 to 0.82) intensities in men and only vigorous (OR=0.44, 95% CI 0.28 to 0.68) intensity in women. Social factors, such as wealth, and chronic health conditions appeared to be more strongly associated with sarcopenia in men.ConclusionWomen are at higher risk of developing incident sarcopenia than men, and this is likely explained by a range of gender-specific risk factors.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Gender-specific risk factors for incident sarcopenia: 8-year follow-up of the English longitudinal study of ageing

Yang

Smıth

Hamer

2018

J Epidemiol Community Health

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“…In the past few years, sarcopenia has been attracting more attention, with the aim of understanding its significance and the extent of its impact on the lives of older adults. QOL is reduced by sarcopenia, because it affects both physical activities and functioning …”

Section: Introductionmentioning

confidence: 99%

Quality of life in cognitively impaired older adults

Bonfiglio

Umegaki

Kuzuya

2019

Geriatrics Gerontology Int

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Aim Quality of life (QOL) in older adults can be affected by many factors, such as dementia, sarcopenia and frailty. This study sought to identify factors that can lead to global deterioration in QOL among older outpatients, including factors stated in caregiver reports. This study also evaluated the discrepancy between QOL ratings reported by the patients and those by their family or professional caregivers. Methods The sample comprised 141 patients with a Mini‐Mental State Examination score ≥20 and a Clinical Dementia Rating of 0.5–1, indicating mild cognitive impairment to mild dementia. QOL was assessed using both components of the EQ‐5D scale, namely, the index score and visual analog scale. In addition, cognitive, neuropsychological, nutritional and physical function tests were carried out, and body measurements were taken. Results Patients’ self‐reported QOL was significantly associated with basic activities of daily living, Mini Nutritional Assessment score and Geriatric Depression Scale‐15. QOL rated by caregivers was significantly associated with basic activities of daily living. EQ‐5D index scores reported by caregivers were lower than those reported by patients. Furthermore, patients achieved a better score for self‐care, usual activities, pain/discomfort and anxiety/depression than those assigned by caregivers. Conclusions As far as the patient's ratings are concerned, the presence of depressive symptoms and a worse nutritional status were indicative of lower QOL, whereas a better functional status was associated with a higher QOL. For caregivers, however, the most relevant factor negatively affecting QOL was basic activities of daily living. Geriatr Gerontol Int 2019; 19: 999–1005.

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“…Moreover, exercise has been shown to safely improve other common conditions in adults and older patients. 46,47) The American College of Sports Medicine and the American Heart Association recommend weight training 2 or 3 times a week to for increased muscle size and strength, even in frail older persons. 48) However, many forms of physical activity are too intense for older adults to maintain over an extended period of time.…”

Section: Exercisementioning

confidence: 99%

Current Status of Sarcopenia in Korea: A Focus on Korean Geripausal Women

Park¹

2018

Ann Geriatr Med Res

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Sarcopenia is defined as an age-associated decline in muscle mass and function caused by several etiologies and mechanisms. Muscle mass and function do not decrease concurrently, and a loss of muscle function may be more highly associated with adverse health outcomes. Despite the clinical significance of sarcopenia, no universally operational definition of sarcopenia or standardized intervention programs are currently available. Sarcopenia, osteoporosis, and obesity share several pathophysiological mechanisms, and a combination of these entities may lead to an increased risk of musculoskeletal, cardio-metabolic, and psychological morbidities especially in geripause populations. Treatment for sarcopenia is mainly nonpharmacological, however, various drugs are currently being developed. It is conceivable that sarcopenia is the next immediate clinical target in musculoskeletal science.

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Relationship between sarcopenia and physical activity in older people: a systematic review and meta-analysis

Cited by 365 publications

References 76 publications

Gender-specific risk factors for incident sarcopenia: 8-year follow-up of the English longitudinal study of ageing

Gender-specific risk factors for incident sarcopenia: 8-year follow-up of the English longitudinal study of ageing

Quality of life in cognitively impaired older adults

Current Status of Sarcopenia in Korea: A Focus on Korean Geripausal Women

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