Relationship Between Sarcopenia and Frailty in a Spanish Cancer in the Elderly Unit: The ONCOSARCO Project

Molina‐Garrido, María‐José; Guillén‐Ponce, Carmen

doi:10.1016/j.jamda.2016.04.025

Cited by 3 publications

(6 citation statements)

References 6 publications

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“…Using either the Fried criteria or the Balducci criteria, frailty was not associated with sarcopenia (using the European Working Group on Sarcopenia in Older Persons [EWGSOP] definition). 34 Other studies outside oncology have shown similar results. 28,35,36 Using three different definitions of sarcopenia and two different frailty definitions, Reijnierse et al showed little uniformity?…”

Section: Discussionsupporting

confidence: 54%

“…7,8,47 Regardless of the definition of frailty that was used, findings similar to ours have been found in other studies. 28,34 The CSR contains limited treatment information; therefore, we are not able to draw any conclusions regarding the impact of cancer treatments on frailty or skeletal muscle measures. Some patients (n=23) were excluded from our analyses because they did not answer a sufficient number of GA variables (≥18 of the 36 variables) to calculate the CFI.…”

Section: Discussionmentioning

confidence: 98%

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Frailty and skeletal muscle in older adults with cancer

Williams

Deal²,

Muss

et al. 2018

Journal of Geriatric Oncology

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 98%

Frailty and skeletal muscle in older adults with cancer

Williams

Deal²,

Muss

et al. 2018

Journal of Geriatric Oncology

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“…However, an increase in frailty prevalence with decreasing SMD was reported. Thus, our results are largely consistent with those obtained using a similar approach (27,29). They are also in accordance with the general perceptions from outside oncology research.…”

Section: Discussionsupporting

confidence: 92%

“…They estimated SMI from cervical CT slices, and found that G8 scores were independently associated with sarcopenia, defined as SMI below a pre-defined threshold. Molina-Garrido et al (27) evaluated 103 older patients who received chemotherapy and reported that sarcopenia was strongly correlated with the physical frailty phenotype (28), but not with frailty based on the Balducci criteria. In their study, sarcopenia was defined according to present consensus, which involves loss of muscle mass, strength, and function (3).…”

Section: Discussionmentioning

confidence: 99%

CT Derived Muscle Measures, Inflammation, and Frailty in a Cohort of Older Cancer Patients

Harneshaug

Benth

Kirkhus

et al. 2020

In Vivo

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Background/Aim: Muscle loss, inflammation, and frailty are prevalent among older cancer patients. We aimed to evaluate whether inflammatory markers could identify muscle loss, and if muscle measures differed between frail and non-frail patients. Patients and Methods: A total of 115 patients ≥70 years old with solid tumors were included. Inflammation was measured using the Glasgow Prognostic Score (GPS), which is based on C-reactive protein (CRP) and albumin levels, and CRP alone. Frailty was evaluated using a modified geriatric assessment (mGA) of eight domains affecting older patients' health status. Computed tomography-derived muscle measures were collected at the level of the third lumbar vertebra. Results: Patients with GPS=2 and CRP>27 mg/l exhibited poorer muscle measures compared to patients with lower levels. No associations between mGA-based frailty and muscle mass were found. Conclusion: Inflammation has detrimental effects on muscle mass. However, GPS or CRP alone cannot be used to identify muscle loss, and muscle measures were not associated with frailty in this series.

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“…Obviously, muscle lean mass loss is a major cause of sarcopenia which includes loss of walking speed and/or grip strength (24-28). There is a major overlap between sarcopenia and frailty (29)(30)(31)(32)(33)(34). Nutritional supplementation can enhance muscle mass and function in persons with sarcopenia (35,36) and in frail persons (37)(38)(39).…”

mentioning

confidence: 99%