Relationship between salivary vitamin D deficiency and oral lichen planus

Gholizadeh, Narges; Pirzadeh, Fatemeh; Mirzaii‐Dizgah, Iraj; Sheykhbahaei, Nafiseh

doi:10.1111/phpp.12567

Cited by 6 publications

(9 citation statements)

References 8 publications

(11 reference statements)

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“…This fact is supported in this study by a significant positive correlation between serum vitamin D concentration and salivary flow rate in the study group and agreed upon by other studies by Stumpf and He et al [7,8]. In contrast, an opposite finding was reported by another study by Gholizadeh et al [15]. They found no significant association between salivary flow rate and vitamin D levels in the serum and saliva.…”

Section: Resultssupporting

confidence: 92%

Untitled

2023

J. Med. Chem. Sci.

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Background: Vitamin D deficiency is widespread and a major global health problem. Dental caries is associated with vitamin D deficiency and its pathophysiologic processes. This research aimed to investigate the effect of vitamin D deficiency on dental caries experience concerning selected physicochemical characteristics (pH, flow rate, calcium ion, and phosphorus ion). Materials and Methods: A case-control study was carried out. The sample comprised 80 females; the study group involved 40 females with a serum vitamin D concentration of less than 10 ng/ml. In addition to the control group involving 40 females who matched the case in number and age but serum vitamin D concentration 30 ng/mol or more, their age range was 20-30 years old. Results: Data from the current study showed that the mean values of the Decayed, Missing, and Filled Surface index and its components (Decayed Surface, Missing Surface) were higher in the study group than those in the control one, highly significant for Decayed Surface. The salivary pH and flow rate were less in the study group than those in the control with statistically significant differences. Both salivary calcium and phosphorous were lower in the study group than in the control with significant differences for phosphorus ions and highly significant for calcium ions. Conclusion:The results of the current study revealed that vitamin D deficiency has a significant effect on dental caries experience in addition to changes in salivary level to selected physicochemical characteristics (pH, flow rate, calcium ion, and phosphorus ion). There is a need for adequate awareness regarding oral hygiene; specifically, the effective preventive measures could help reduce the effect of vitamin D deficiency on oral health.

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Section: Resultssupporting

confidence: 92%

Untitled

2023

J. Med. Chem. Sci.

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“…Tak et al (17) also found out that vitamin D serum levels in patients diagnosed with OLP were less than the levels in healthy subjects, significantly lower levels of vitamin D were shown in cases that suffer from erosive lichen planus. Taken all these results together will support the role of vitamin D in initiating or increasing the severity of OLP disease (32).…”

Section: Expression Of Il-17a and Il-6 Genesmentioning

confidence: 57%

Serum vitamin D level in healthy individuals versus patients with symptomatic and asymptomatic oral lichen planus

H¹,

Hussein²,

Sadek³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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The aetiology of oral lichen planus (OLP) is multifactorial, having variable triggers. A role for vitamin D related to the immune system has been established. Vitamin D modulating effect is on the adaptive and innate immune responses. Our study aimed to compare serum levels of vitamin D in patients having different clinical symptoms of OLP (symptomatic or asymptomatic) with healthy individuals. Also, in this study, for further evaluation, the expression level of interleukin-17A and interleukin-6 (IL-17A and IL-6) was evaluated because the presence of active vitamin D reduces the expression of these proinflammatory factors. This study was included three groups with 30 volunteers in each. The first group included asymptomatic oral lichen planus patients (reticular or plaque-like lesions). The second group consisted of symptomatic oral lichen planus patients (atrophic or bullous-erosive lesions). In contrast, the third group consisted of healthy control subjects. The serum 25-hydroxyvitamin D was measured between the three groups and then correlated with clinical manifestation of oral lichen planus, either symptomatic or non-symptomatic. The Real-Time PCR technique was used to evaluate the expression of IL-17A and IL-6. Patients with symptomatic OLP (second group) had statistically significantly lower Vitamin D levels than asymptomatic OLP patients (first group). Healthy Controls (third group) exhibited statistically significantly higher vitamin D levels than OLP groups. The results of IL-17A and IL-6 genes expression showed that the presence of vitamin D had a statistically significant effect on reducing the expression of these two pro-inflammatory cytokines among symptomatic and asymptomatic OLP patients. Also, the results showed that there was a statistically significant difference between OLP patients (group I and II) and the control group (group III). In general, the current study results showed that lack of vitamin D had an important role in initiating or increasing the OLP's severity.

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“…A recent study in Tehran, Iran, evaluated serum and salivary levels of vitamin D in OLP patients and reported that serum levels of this vitamin do not have a significant difference in comparison to controls. In contrast, salivary levels of vitamin D were significantly lower in OLP patients [ 40 ]. This might be due to the upregulation of vitamin D-binding protein (DBP) in inflammatory and immune system-related disorders that causes an increased record of serum levels of vitamin D but does not have an impact on salivary levels [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, salivary levels of vitamin D were significantly lower in OLP patients [ 40 ]. This might be due to the upregulation of vitamin D-binding protein (DBP) in inflammatory and immune system-related disorders that causes an increased record of serum levels of vitamin D but does not have an impact on salivary levels [ 40 ]. Despite the aforementioned studies in Iran, a study in India reported that the serum levels of vitamin D were significantly lower in OLP patients [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Vitamin Profile in Oral Lichen Planus Patients in Southwest of Iran

Rezazadeh

Haghighat

2021

BioMed Research International

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Introduction. Oral lichen planus (OLP) is a chronic mucocutaneous disease. It is mainly an immune system-related disorder. Vitamins can modulate immune system functions, and thus, vitamin deficiency might have roles in exacerbating OLP. We aim to determine the serum levels of vitamins A, B12, C, D3, and E in OLP patients. Methods and Materials. 34 OLP patients referred to Shiraz Dental School entered the study. Blood samples were collected and levels of A, B12, C, D3, and E vitamins were measured in serum. 43 healthy people were also included as the control group. Serum levels of vitamins were measured by HPLC (A, B12, D3, and E) and Kiazist analyzing kit (vitamin C). Results. Most of the patients were female (62.3%), and the mean age of patients was 48.03 ± 11.57 . Serum levels of vitamins A, C, and E were lower in OLP patients in comparison with the healthy group; however, the difference was not significant. Vitamins B12 and D3 were higher in the OLP group but the difference was not significant. Conclusion. Serum levels of vitamins A, B12, C, D3, and E do not have a significant difference in OLP patients and healthy groups. These vitamins may not have a considerable role in OLP pathogenesis in the southwest of Iran.

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Relationship between salivary vitamin D deficiency and oral lichen planus

Cited by 6 publications

References 8 publications

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Serum vitamin D level in healthy individuals versus patients with symptomatic and asymptomatic oral lichen planus

Serum Vitamin Profile in Oral Lichen Planus Patients in Southwest of Iran

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