Relationship between salivary mucin or amylase and the periodontal status

Sánchez, G.; Miozza, VA; Delgado, Alejandra; Busch, Lucila

doi:10.1111/odi.12039

Cited by 37 publications

(43 citation statements)

References 27 publications

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“…In support of this idea, CXCL8 staining was increased in the epithelium of patients with cystic fibrosis and colocalized with mucins [25]. Mucins are correlated with the severity of periodontal disease [26]. However, mucin 2 can even be inversely correlated with CXCL8 expression, at least in pediatric patients with Crohn's disease [27].…”

Section: Discussionsupporting

confidence: 54%

Chemokine expression of oral fibroblasts and epithelial cells in response to artificial saliva

et al. 2015

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Section: Discussionsupporting

confidence: 54%

Chemokine expression of oral fibroblasts and epithelial cells in response to artificial saliva

et al. 2015

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“…The increased protein levels in our study in the test groups could be due to the inflammatory process that activates the sympathetic system to enhance the synthesis and secretion of some proteins (as evidenced by increased amylase levels) thereby increasing the protective potential of saliva against the diseases [12,13].…”

Section: Collection Of Salivamentioning

confidence: 99%

“…The increased levels may be due to the response of salivary glands to inflammatory diseases like gingivitis and periodontitis resulting in increased synthesis and secretion of certain acinar proteins like α-amylase so as to enhance the oral defense mechanism [12,13].…”

Section: Collection Of Salivamentioning

confidence: 99%

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Estimation of Levels of Salivary Mucin, Amylase and Total Protein in Gingivitis and Chronic Periodontitis Patients

Kejriwal

Bhandary

Thomas

et al. 2014

JCDR

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Background: Periodontal diseases are a group of inflammatory conditions resulting from interaction between a pathogenic bacterial biofilm and susceptible host's inflammatory response eventually leading to the destruction of periodontal structures and subsequent tooth loss. Hence, investigation of salivary proteins in individuals with periodontal diseases may be useful to enhance the knowledge of their roles in these diseases. Materials and Methods:This case-control study was conducted at A.B. Shetty Memorial Institute of Dental Sciences, Mangalore. The study comprised of 90 patients of age between 25-60 years who were clinically examined and divided into three groups of 30 each: namely clinically healthy, gingivitis and chronic periodontitis. These were classified according to the values of gingival index score, clinical attachment loss and probing pocket depth. Unstimulated saliva was collected and salivary mucin, amylase and total protein levels were determined. Statistical analysis:Results obtained were tabulated and statistically analyzed using ANOVA test and Karl pearson's correlation test. Results:The results of the study showed an increased concentration of salivary mucin, amylase and total protein in gingivitis patients and increased levels of amylase and total protein in saliva of chronic periodontitis patients compared to healthy individuals which were statistically significant. A decrease in mucin concentration was observed in the periodontitis group compared to gingivitis group. A positive correlation was present between salivary mucin, amylase and total protein levels in the three groups.Conclusion: Salivary mucin, amylase and total protein may serve as an important biochemical parameter of inflammation of the periodontium. Also, it can be hypothesized that various enzyme inhibitors might be useful as a part of host modulation therapy in the treatment of periodontal diseases.

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“…It was reported that HIF-1 mediated the induction of TFF gene expression and provided an adaptive link for the maintenance of the barrier function during hypoxia of gastric/intestinal lining cells [84,85]. Salivary mucins form a protective layer on the oral surfaces including that of oral sulcular and junctional epithelia, which serve as a physical barrier against bacterial invasion and function as essential antimicrobial macromolecules [86,87]. Similar to TFF, mucins' production was upregulated in hypoxia [88].…”

Section: Hif and Epithelial Barrier Functionmentioning

confidence: 99%

Role of the Hypoxia-Inducible Factor in Periodontal Inflammation

Wang¹,

Chen²,

Leung³

2017

Hypoxia and Human Diseases

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Human periodontitis is a chronic inlammatory disease induced by opportunistic Gramnegative anaerobic bacteria at the tooth-supporting apparatus. Within the gingivitisafected sulcus or periodontal pocket, the resident anaerobic bacteria interact with the host inlammatory reactions leading to a lower oxygen or hypoxic environment. A cellular/tissue oxygen-sensing mechanism and its appropriate regulation are needed to assist tissue adaptation to natural/pathology-induced variations in oxygen availability. In this chapter, we reviewed the biological relevance of hypoxia in periodontal/oral cellular development, epithelial barrier function, periodontal inlammation, and immunity. The role of hypoxia-inducible factor-1α in pathogen-host cross talk and alveolar bone homeostasis was also discussed. The naturally occurring pathophysiological process of hypoxia appeared to entail fundamental relevance for periodontal defense and regeneration.

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Relationship between salivary mucin or amylase and the periodontal status

Abstract: The increment of mucin and amylase output in relation to periodontal status indicates that salivary glands respond to the disease by increasing the protective potential of saliva when necessary and return to the normal rate of secretion after the resolution of the inflammatory process.

Cited by 37 publications

References 27 publications

Chemokine expression of oral fibroblasts and epithelial cells in response to artificial saliva

Chemokine expression of oral fibroblasts and epithelial cells in response to artificial saliva

Estimation of Levels of Salivary Mucin, Amylase and Total Protein in Gingivitis and Chronic Periodontitis Patients

Role of the Hypoxia-Inducible Factor in Periodontal Inflammation

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