Relationship between reflux and laryngeal cancer

Coca‐Pelaz, Andrés; Rodrigo, Juan P.; Takes, Robert P.; Silver, Carl E.; Paccagnella, Daniela; Rinaldo, Alessandra; Hinni, Michael L.; Ferlito, Alfio

doi:10.1002/hed.23208

Cited by 43 publications

(55 citation statements)

References 30 publications

(50 reference statements)

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“…Additionally, male sex was shown to be a significant risk factor for the development of cancer in GERD patients, particularly cancers of the oropharynx and hypopharynx. The relationship between GERD and cancers of the hypopharynx and oropharynx remains far from established [8,10]. This study succeeded in identifying a link between these two entities; however, our results should be interpreted in light of a limitation common to nationwide population-based studies [3,14,[17][18][19]21,22], namely a lack of information related to carcinogen exposure history (e.g., smoking habits, alcohol consumption, and infection with human papillomavirus) in the dataset.…”

Section: Discussionmentioning

confidence: 84%

“…Despite a lack of available data on the subject, an increasing number of investigators believe that a relationship exists between GERD and HNCs, particularly with regard to laryngo-pharyngeal malignancies [7]. Nonetheless, most previous studies used only a small number of subjects and focused primarily on the link between GERD and laryngeal cancer [8][9][10][11]. To date, no research has been conducted to elucidate the differential carcinogenic effects of GERD on specific sub-sites of the head and neck.…”

mentioning

confidence: 99%

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Acid reflux and head and neck cancer risk: A nationwide registry over 13 years

Kuo¹,

Chen²,

Shiao³

et al. 2015

Auris Nasus Larynx

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Section: Discussionmentioning

confidence: 84%

mentioning

confidence: 99%

Acid reflux and head and neck cancer risk: A nationwide registry over 13 years

Kuo¹,

Chen²,

Shiao³

et al. 2015

Auris Nasus Larynx

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“…Use of coal (Sapkota et al, 2013) and silica dust exposure have also been implicated (Chen and Tsu, 2012). A similar irritation dependent mechanism might be relevant for the finding that gastrectomy for peptic ulcer disease might entail a long-term increase (Lagergren and Lindam, 2012) as does laryngopharyngeal reflux (Tae et al, 2011) but apparently not gastroesophageal reflux (Coca-Pelaz et al, 2013).…”

Section: Introductionmentioning

confidence: 95%

Epidemiological Evaluation of Laryngeal Cancer Incidence in Kazakhstan for The Years 1999-2009

Igissinov¹,

Zatoskikh²,

Moore³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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The purpose was to provide a descriptive epidemiological assessment of the incidence of cancer of the larynx in Kazakhstan and spatial evaluation with gender characteristics. Thgis retrospective study covered all new cases of laryngeal cancer in 11 years (1999-2009). The total number was 4,967 cases, 4,535 (91.3%) in males and 432 (8.7%) in women, with a ratio of 10.5:1. The higher incidence in men compared to women was evident in all age groups, the differences being statistically significant (p<0.05). At the same time revealed a unimodal growth with age, peaking at 70 years and older both sexes. In the dynamics, incidence rates of laryngeal cancer demonstrated a tendency to decrease, in women (T=−6.7%) this being more pronounced than in men (T=−3.3%). Levels were determined to produce cartograms of cancer of the larynx for male and female populations, clear geographical variation being evidenced. The data are discussed with reference to possible risk factors.

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“…This may imply a different disease than classic larynx cancer with a unique pathophysiology. Other risk factors, including human papilloma virus and laryngopharyngeal reflux, remain under investigation and their link to laryngeal cancer is controversial (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Characteristics and outcome of laryngeal squamous cell carcinoma in young adults

et al. 2016

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Abstract. Laryngeal carcinoma rarely occurs in the young adult population. Therefore, the optimal treatment for this age group is unclear, specifically regarding organ preservation treatment. In order to assess the distinct characteristics of laryngeal squamous cell carcinoma (SCC) in young adults and describe the effect of treatment on survival, a retrospective chart review of all patients aged <40 years, who were treated in a tertiary referral center for laryngeal SCC between January 1960 and December 2013, was performed. Patients who were treated prior to and following the Veterans study, representing an arbitrary point which started the organ preservation era, were compared. A total of 29 patients (male:female ratio, 2.6:1) were identified. The mean age at diagnosis was 35±5 years and 17 patients (59%) were smokers. In total, 12 (41%) of patients were stage I, 4 (14%) were stage II, 8 (28%) were stage III and 5 (17%) were stage IV. Glottic tumors were present in 20 (69%) of patients and supraglottic tumors in 6 (21%); the site of tumor origin could not be determined in 3 (10%) of patients. Surgery was performed in 11 (38%) of patients, radiation in 21 (72%) and chemotherapy in 5 (17%). A comparison between patients treated prior to and following the Veterans study demonstrated a 2-year higher laryngectomy-free survival rate of 53% and 78%, respectively (P=0.299). The 2-year disease-free survival rate was 93% for patients who were treated prior to the Veterans study and 71% for patients who were treated after (P=0.001), with no significant change in overall survival (P= 0.413). The results suggest that the characteristics and behavior of laryngeal carcinoma in young adults is similar to older adults. Higher rates of 2-year laryngectomy-free survival were noted in patients treated following the organ preservation era with no significant difference in survival compared with patients who were treated before.

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Relationship between reflux and laryngeal cancer

Cited by 43 publications

References 30 publications

Acid reflux and head and neck cancer risk: A nationwide registry over 13 years

Acid reflux and head and neck cancer risk: A nationwide registry over 13 years

Epidemiological Evaluation of Laryngeal Cancer Incidence in Kazakhstan for The Years 1999-2009

Characteristics and outcome of laryngeal squamous cell carcinoma in young adults

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