Relationship between Reactive Oxygen Metabolites and Carotid Intima-Media Thickness in Subjects with Hypercholesterolemia

Kotani, Kazuhiko; Koibuchi, Harumi; Miyamoto, Michiaki; Yamada, Toshiyuki; Taniguchi, Nobuyuki

doi:10.1159/000320312

Cited by 30 publications

(24 citation statements)

References 14 publications

(13 reference statements)

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“…CIMT is measured noninvasively by ultrasonography and is a well-established index of early-stage atherosclerosis [25,26]. Our finding that CIMT is increased in patients with CSX in spite of angiographically normal coronary arteries confirms these previous findings [27,28].…”

Section: Discussionsupporting

confidence: 89%

Uric Acid Level and Its Association with Carotid Intima-Media Thickness in Patients with Cardiac Syndrome X

Açıkgöz

Ermiş²,

Yağmur³

et al. 2011

Med Princ Pract

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Objective: The aim of our study was to evaluate serum uric acid level and its relationship with carotid intima-media thickness (CIMT) in patients with cardiac syndrome X (CSX). Subjects and Methods: A total of 50 patients with CSX (28 females/22 males, 51.0 ± 10.9 years) and 40 controls (27 females/13 males, 53.0 ± 10.2 years) were included in the study. All subjects underwent a noninvasive stress test and conventional coronary angiography. Serum uric acid levels were measured and B mode ultrasonography was performed to assess CIMT in all subjects. Results: Serum uric acid levels were higher in patients with CSX than in the control subjects (5.1 ± 1.8 vs. 3.9 ± 1.3 mg/dl; p = 0.002). The CIMT was higher in patients with CSX than in the control subjects (0.75 ± 0.18 vs. 0.63 ± 0.09 mm; p < 0.001). A significant correlation was found between serum uric acid values and CIMT measurements in patients with CSX (r = 0.666, p < 0.001). Conclusions: Serum uric acid levels were higher in patients with CSX and elevated serum uric acid levels were associated with carotid atherosclerosis, thereby indicating that elevated serum uric acid levels might contribute to the development of subclinical atherosclerosis in CSX patients.

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Section: Discussionsupporting

confidence: 89%

Uric Acid Level and Its Association with Carotid Intima-Media Thickness in Patients with Cardiac Syndrome X

Açıkgöz

Ermiş²,

Yağmur³

et al. 2011

Med Princ Pract

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“…28) However, our findings showed that dROMs were not correlated with carotid artery IMT in our cohort. Forty-four percent of the subjects in our cohort were either healthy participants or subjects with mild disease conditions, which is likely reflected in the relatively narrow range of carotid artery IMT values between 0.44 and 1.12 mm in our cohort and may be responsible for the lack of significant associations between d-ROMs and carotid artery IMT.…”

Section: Discussioncontrasting

confidence: 74%

“…26,27) Because oxidative stress has been shown to represent the balance of production of ROS and antioxidant capacity, it is more appropriate to evaluate ROS and antioxidant capacity simultaneously. However, only one study has reported an association between d-ROMs and carotid artery IMT in patients with hypercholesterolemia, 28) and, thus far, no study has examined the associations among d-ROMs, BAP values, and carotid artery IMT concurrently. Therefore, we measured d-ROMs and BAP values as indices for ROS production and antioxidant potential, respectively, and carotid artery IMT within the same subjects to investigate the association between carotid artery IMT and clinical parameters values, including d-ROMs and BAP.…”

mentioning

confidence: 99%

Biological Antioxidant Potential Negatively Correlates With Carotid Artery Intima-Media Thickness

et al. 2016

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SummaryOxidative stress is a crucial factor in the pathogenesis and development of cardiovascular disease. Recently, simplified methods for the detection of reactive oxygen species (ROS) using the derivatives of reactive oxygen metabolites (dROMs) test as an index of ROS products and the biological antioxidant potential (BAP) test as an index of antioxidant potential have been utilized. These methods are easy to perform, quick, inexpensive since they use small equipment, and provide reliable results compared with established oxidative stress and antioxidant markers. Because oxidative stress has been shown to represent the balance of production of ROS and antioxidant capacity, it is more appropriate to evaluate ROS and antioxidant capacity simultaneously. However, no study has examined the associations among d-ROMs, BAP values, and carotid artery intima-media thickness (IMT) concurrently. Therefore, we studied the associations among dROMs, BAP values, and the carotid artery IMT. Carotid artery IMT, blood pressure (BP), fasting circulating d-ROMs, BAP, glucose metabolism, lipid, and C-reactive protein levels were measured in 95 subjects (age: 49.5 ± 13.8 years; men: 41; women: 54), including 42 healthy subjects and 53 patients with hypertension, dyslipidemia, and diabetes mellitus who were not on medication. The results of multiple regression analysis revealed that dependent carotid artery IMT determinants remained significantly associated with age, systolic BP, total cholesterol, and BAP, whereas dependent BAP determinants remained significantly associated with body mass index and carotid artery IMT. BAP was strongly correlated with carotid artery IMT in our cohort. Our results suggest that BAP may be a useful risk marker for carotid atherosclerosis. (Int Heart J 2016; 57: 220-225) Key words: Antioxidant markers, Carotid atherosclerosis, Oxidative stress O xidative stress is involved as a crucial factor in the pathogenesis and development of a variety of chronic and degenerative diseases, including aging, cancer, and cardiovascular disease. An enhanced oxidative stress status, defined as an imbalance between oxidants and antioxidants in favor of the former, plays a significant role in the onset and progression of atherosclerosis.1-3) Levels of oxidative stress markers, such as thiobarbituric acid-reactive substances (TBARSs), 4) 8-iso-prostaglandin (PG) F 2 α, 5) oxidized low-density lipoprotein (LDL) (oxLDL), 6) and myeloperoxidase (MPO), 7,8) independently predict an increased risk for coronary artery disease (CAD). In contrast, glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase enzymes, and total antioxidant status (TAS) are antioxidant markers that constitute the first line of defense against oxidative stress by removing key reactive oxygen species (ROS).9) Meta-analyses of observational studies have identified inverse associations of circulating SOD, GPx, and catalase activity levels with CAD. 10)Furthermore, another study has demonstrated that a low GPx1 activity level was independently a...

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“…For instance, clinical studies have demonstrated that high ROM levels could be a predictor of cardiovascular disease progression [36, 37]. It is also known that high ROM levels are an independent predictor of obesity (odds ratio: 2.5; P < 0.001) in women [38].…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Relationship between Plasma Reactive Oxygen Metabolites and Periodontal Condition in the Maintenance Phase of Periodontal Treatment

et al. 2014

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Aim. The present cohort study describes the longitudinal relationship between plasma oxidative status and periodontitis progression during the maintenance phase of treatment. Materials and Methods. Forty-five patients (mean age 58.8 years) were monitored from 2008 to 2013. Periodontal conditions, including probing pocket depth (PPD) and clinical attachment level (CAL), were recorded. Measurements of plasma reactive oxygen metabolites (ROM) and biologic antioxidant potential (BAP) were performed to evaluate plasma oxidative status. The patients were assigned into 2 groups as low and high plasma ROM level using a cut-off value which was median of plasma ROM level at baseline. Results. In the subjects with low plasma ROM level at baseline, changes in mean CAL were positively correlated with changes in plasma ROM levels, bleeding on probing, and plaque control record, but not with PPD. In the subjects with high plasma ROM at baseline, changes in CAL were significantly associated with only PPD at baseline. On the other hands there were no significant associations between changes in CAL and those in plasma BAP levels. Conclusions. When plasma ROM level in periodontitis patients was low, increases in plasma ROM level were associated with those in CAL during the maintenance phase of treatment.

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Relationship between Reactive Oxygen Metabolites and Carotid Intima-Media Thickness in Subjects with Hypercholesterolemia

Cited by 30 publications

References 14 publications

Uric Acid Level and Its Association with Carotid Intima-Media Thickness in Patients with Cardiac Syndrome X

Uric Acid Level and Its Association with Carotid Intima-Media Thickness in Patients with Cardiac Syndrome X

Biological Antioxidant Potential Negatively Correlates With Carotid Artery Intima-Media Thickness

Longitudinal Relationship between Plasma Reactive Oxygen Metabolites and Periodontal Condition in the Maintenance Phase of Periodontal Treatment

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