Relationship between Ragweed-Reagins and Serum Immunoglobulins

Goodfriend, L.; Perelmutter, L.; Rose, B.

doi:10.1159/000229841

Cited by 12 publications

(9 citation statements)

References 6 publications

(7 reference statements)

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“…The first was used for adsorption of wheatsensitive serum (1:10), followed by elution with 2 m KI, pH 9.0. Each 3. PK titers of ragweed and wheat sensitive sera before and after incubation with an a-gliadin immunosorbent.…”

Section: Resultsmentioning

confidence: 99%

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Isolation of Antibodies to Gliadin and Ragweed Antigen E with the Use of Immunosorbents

Goldstein¹,

Underdown²,

Dc³

et al. 1969

Int Arch Allergy Immunol

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Section: Resultsmentioning

confidence: 99%

“…

It has been established [1,2,3] that human rcagins belong to a unique class of immunoglobulins, IgE. The labile nature and exceedingly low concentration [4] of these antibodies in atopic sera have hindered efforts to isolate them in quantity sufficient for direct structural studies.

…”

mentioning

confidence: 99%

Isolation of Antibodies to Gliadin and Ragweed Antigen E with the Use of Immunosorbents

Goldstein¹,

Underdown²,

Dc³

et al. 1969

Int Arch Allergy Immunol

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“…If we consider that DSCG does not inhibit the antigen-induced mediator release from the leucocytes of allergic patients (13), and that a certain heat labile and homocytotropic IgG antibody is present in the serum of allergic patients (21)(22)(23), the reaction in rats sensitized with DNP-As and Bordetella pertussis may be attributed to other antibodies acting together with the reaginic antibody. A slight inhibition of mast cell degranulation by BPS in the actively sensitized rats suggests that the drug does act on other antibodies as well as on the reaginic antibody.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of the Anti-Allergic Effects of Disodium Baicalein 6-Phosphate (BPS) and Disodium Cromoglycate (DSCG)

Koda

Watanabe

Yanagihara

et al. 1977

Japanese Journal of Pharmacology

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Abstract-A comparative study was carried out on the effects of a soluble derivative of baicalein, disodium baicalein 6-phosphate (BPS) and disodium cromoglycate (DSCG) on the immediate type allergic reactions.BPS not only inhibited reaginic antibody mediated reactions including antigen-induced mediator release from monkey lung, homologous PCA in rats, and reaginic antibody-mediated degranulation of mast cell, but also non-reaginic antibody-mediated reactions such as mediator release from guinea pig lung sensitized with ovalbumin and that from human lung caused by anti IgE. The agent, however, did not affect the mediator release from lung of rats sensitized with dinitrophynylated ascaris extract plus Bordetella pertussis. On the other hand, DSCG showed characteristic properties as an inhibitor of reaginic antibody-mediated reaction.It is thus assumed that the functional site of reaginic antibody is well fixed with DSCG at a definite distance between the two-chromone-nuclei while that of IgG is readily fixed with the two molecules of baicalein or BPS.Baicalein and baicalin are flavones contained in the radix of Scutellaria baicalensis GEORGI (Woogon), which from ancient times has often been used in Chinese medicine as a remedy for allergic diseases and inflammation. We (1-5) have already reported the anti allergic activity of baicalein and its derivatives, and these substances also have a potent protective action against active and passive anaphylaxis. These agents were also found to inhibit reagin-mediated reaction as well as disodium cromoglycate (DSCG). DSCG does inhibit reagin-mediated reaction with a fairly high specificity (6-12), however, inhibits not at all or only slightly non-reaginic antibody-mediated reactions (7-12) and the mediator release by specific antigen from the leucocytes of allergic patient (13).From the viewpoint of chemical structures, baicalein is a monochromone derivative while DSCG is a symmetric dichromone derivative, as shown in Fig. 1

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“…Studies by a number of investigators (1,2,6,7,8,9) strongly support the concept that most, if not all, reagins in ragweed-allergic serum do not belong to the yG, yA, yD and yM immunoglobulin classes. More recently, I shizaka et al (10) have provided direct evidence that reagins represent a unique type (yE) of immuno globulin.…”

Section: Discussionmentioning

confidence: 95%

“…For each of 6 sera examined, the bulk of the reagins were localized in two well-defined areas of the chromatograms containing slow and fast-moving yG globulins, respectively (2). In the present study, this distribution of serum reagins into 2 fractions, termed pre-and post-gradient reagins (2), was analysed further by re-cycling experiments using the same ion-exchanger. In addition the pre-and post-gradient reagins were compared with respect to skin-fixation, molecular size and sus ceptibility to inactivation by heat and 2-mercaptoethanol.…”

Section: Introductionmentioning

confidence: 92%

Properties of Two Chromatographically Distinct Reagins in the Sera of Ragweed Atopic Individuals

Goodfriend¹,

Perelmutter²

1968

Int Arch Allergy Immunol

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Relationship between Ragweed-Reagins and Serum Immunoglobulins

Cited by 12 publications

References 6 publications

Isolation of Antibodies to Gliadin and Ragweed Antigen E with the Use of Immunosorbents

Isolation of Antibodies to Gliadin and Ragweed Antigen E with the Use of Immunosorbents

A Comparative Study of the Anti-Allergic Effects of Disodium Baicalein 6-Phosphate (BPS) and Disodium Cromoglycate (DSCG)

Properties of Two Chromatographically Distinct Reagins in the Sera of Ragweed Atopic Individuals

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