Relationship between quadriceps echo intensity and functional and morphological characteristics in older men and women

Akima, Hiroshi; Yoshiko, Akito; Tomita, Aya; Ando, R.; Saito, Akira; Ogawa, Madoka; Kondo, Shohei; Tanaka, Noriko

doi:10.1016/j.archger.2017.01.014

Cited by 86 publications

(93 citation statements)

References 28 publications

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“…The advantages of US are that it is noninvasive as well as less expensive and more portable than other medical imaging modalities such as magnetic resonance imaging, computed tomography, and dual-energy X-ray absorptiometry. The reliability and validity of MT and EI have been confirmed in the literature [19,21,24,26,28,29]. MT is positively associated with the muscle size and is thus used as an index of muscle quantity [24,25].…”

mentioning

confidence: 58%

“…B-mode US (LOGIQ e; GE Healthcare, Chicago, IL, USA) with an 8-to 12-MHz linear-array probe (probe width, 3.8 cm) was used to assess the thickness and EI of the quadriceps muscle and the thickness of the subcutaneous adipose tissue at the anterior midthigh (midway between the greater trochanter and lateral condyle of the femur) in both limbs, as previously described [21]. All measurements were carried out with the patients in the supine position and knees fully extended.…”

Section: Mt and Ei As Measured By Usmentioning

confidence: 99%

“…A higher ratio of intramuscular fat to muscle tissue generally represents lower muscle quality [18][19][20], and one study showed that this ratio in the paretic limb was 4.9% higher than that in the nonparetic limb with statistical significance [6]. Lower muscle quality is associated with lower physical performance, higher insulin resistance, [6,18,21], and muscle atrophy [22,23]. Therefore, improvement of muscle quality and quantity is important in clinical settings.…”

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confidence: 99%

“…US is an ideal technique for the measurement of muscle quality and quantity, which are frequently assessed according to the muscle thickness (MT) and echo intensity (EI) [9,17,20,21,[24][25][26][27]. The advantages of US are that it is noninvasive as well as less expensive and more portable than other medical imaging modalities such as magnetic resonance imaging, computed tomography, and dual-energy X-ray absorptiometry.…”

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confidence: 99%

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Relationship of Quadriceps Muscle Thickness with Motor Paralysis and Muscle Echo Intensity in Post-Stroke Patients

Maeda

Imada²,

Ishida

et al. 2019

Eur Neurol

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Introduction: Quadriceps muscle atrophy and quality loss, defined as an increased ratio of intramuscular fat and/or connective tissue, are often observed especially in the paretic limb of post-stroke patients. This study was performed to examine the relationship of quadriceps muscle thickness (MT) with muscle echo intensity (EI) and the severity of motor paralysis after stroke. Methods: Thirty-six hemiparetic subacute post-stroke patients were enrolled. We examined the MT (index of muscle quantity) and the EI (index of muscle quality) at the anterior mid-thigh in both limbs. We also assessed the Brunnstrom stage (BR stage), subcutaneous adipose tissue thickness, time since stroke, age, body weight, sex, number of medications, and nutritional and inflammation status. Results: The MT in the paretic limb was explained by the BR stage (β = –0.26, p < 0.01), body weight (β = 0.68, p < 0.01), and serum albumin (β = 0.34, p < 0.01), with an adjusted R² of 0.81. The MT in the non-paretic limb was explained by the muscle EI (β = –0.55, p < 0.01) and age (β = –0.40, p < 0.01), with an adjusted R² of 0.69. The muscle EI was explained by the MT in the paretic limb (β = –0.34, p < 0.01) and non-paretic limb (β = –0.69, p < 0.01). Conclusions: Our results suggest that motor paralysis, aging, and malnutrition contribute to quadriceps atrophy in post-stroke patients. Moreover, a potential countermeasure to diminish muscle quality loss is maintenance of muscle quantity.

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confidence: 58%

Section: Mt and Ei As Measured By Usmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Relationship of Quadriceps Muscle Thickness with Motor Paralysis and Muscle Echo Intensity in Post-Stroke Patients

Maeda

Imada²,

Ishida

et al. 2019

Eur Neurol

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“…In contrast, to our knowledge, no previous study has examined the relationship between intramuscular composition and muscle material properties (including shear modulus). Recently, intramuscular composition has been indirectly evaluated by calculating the echo intensity of ultrasound image 23,24) . Unfortunately, however, although B-mode ultrasound images were obtained in the present study, ultrasound equipment settings such as gain, depth, and focus depth, which can influence the echo intensity, were not constant across subjects.…”

Section: Discussionmentioning

confidence: 99%

No association between passive material property and cross-sectional area in human hamstring

Hirata

Miyamoto‐Mikami

Kimura

et al. 2017

JPFSM

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The passive material properties of a muscle, as evaluated by shear or Young's modulus, can vary depending on the muscle cross-sectional area (CSA), since intramuscular compositions such as adipose tissue and connective tissue change with muscle hypertrophy and atrophy. However, the relationship remains unclear between the passive material properties and CSA of a muscle. Therefore, we examined whether passive muscle shear modulus is related to muscle CSA in the human hamstring. The shear modulus and anatomical CSA of the biceps femoris, semitendinosus, and semimembranosus were measured in 71 healthy young males with the hip flexed at 70° and knee fully extended. The shear modulus of each muscle was measured using ultrasound shear wave elastography. Muscle CSA was assessed using panoramic ultrasound imaging. There were individual differences in muscle shear modulus as well as muscle CSA. The coefficients of variation (CVs) of muscle shear modulus were 41.4% (range: 8.8 -54.3 kPa), 33.0% (range: 8.4 -57.3 kPa), and 41.1% (range: 18.2 -107.1 kPa) for the biceps femoris, semitendinosus, and semimembranosus, respectively. There were no significant correlations between shear modulus and CSA in each or overall hamstring muscle (absolute r < 0.113). The present findings indicate that, although the passive material property of muscle is not the same among individuals, it is substantially independent of the muscle CSA, at least in the hamstring.

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The utility of the ultrasonographic assessment of the lower leg muscles to evaluate sarcopenia and muscle quality in older adults

Isaka

Sugimoto

Fujimoto

et al. 2020

JCSM Clinical Reports

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BackgroundThe assessment of muscle quality is expected to help predict the prognosis of sarcopenia and examine the response to intervention. Ultrasonography can be used to evaluate approaches for determining muscle quantity and quality. We focused on the lower leg muscles and examined the relationship between the ultrasonographic assessments and the components of sarcopenia and muscle quality by comparing them with those of the quadriceps muscle (QFM).Methods47 physically healthy older participants aged 78.3 ± 6.0 years (53% male) were enrolled in this cross‐sectional study. Muscle thickness (MT) and echo intensity (EI) of the lower leg muscles and QFM were assessed with ultrasonography. Muscle mass, grip strength, and gait speed, and lower leg muscle strength were measured. Muscle quality was calculated using a formula: leg muscle strength/leg muscle mass.ResultsThe MTs and EIs of the tibialis anterior muscle (TA) and QFM were significantly associated with grip and leg strength. We observed a significant correlation in the MTs and EIs of the lower leg muscles and QFM. The EIs of the lower leg muscles and QFM showed significant negative correlations with muscle quality. In the multiple linear regression model, the EI of the TA and QFM was extracted as an independent factor of muscle quality (TA: β = −0.35, p = 0.0358; QFM: β = −0.30, p = 0.0327).ConclusionsThe ultrasonographic assessments of the lower leg muscles, especially the TA, were associated with sarcopenia components and muscle quality equal to or greater than those of the QFM.

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Relationship between quadriceps echo intensity and functional and morphological characteristics in older men and women

Cited by 86 publications

References 28 publications

Relationship of Quadriceps Muscle Thickness with Motor Paralysis and Muscle Echo Intensity in Post-Stroke Patients

Relationship of Quadriceps Muscle Thickness with Motor Paralysis and Muscle Echo Intensity in Post-Stroke Patients

No association between passive material property and cross-sectional area in human hamstring

The utility of the ultrasonographic assessment of the lower leg muscles to evaluate sarcopenia and muscle quality in older adults

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