Relationship between psychological state and level of activity of extrinsic gut innervation in patients with a functional gut disorder

Emmanuel, Anton; Mason, Heather J; Kamm, Michael A.

doi:10.1136/gut.49.2.209

Cited by 57 publications

(37 citation statements)

References 35 publications

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“…The following maybe involved: the long period of constipation decreased the ability of the defecation reflex; the extrinsic autonomic innervation to the gut is disturbed; the presence of pelvic nerve damage or lesion in the lower spinal cord; or the possible alterations in central processing of visceral afferent information arising from the rectum, such as activation of pain inhibitory systems or attenuation of central arousal systems. [36][37][38] It should be mentioned that C-IBS patients might have been constipated for a previous period while D-IBS patients had defecated before the study, and these different conditions might have some effects on the results.…”

Section: Discussionmentioning

confidence: 96%

Visceral hypersensitivity following cold water intake in subjects with irritable bowel syndrome

Zuo

Shi

et al. 2006

J Gastroenterol

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Section: Discussionmentioning

confidence: 96%

Visceral hypersensitivity following cold water intake in subjects with irritable bowel syndrome

Zuo

Shi

et al. 2006

J Gastroenterol

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“…It is reported that anxiety is associated with increased bowel frequency, while depressed patients tend to be constipated (Gorard et al, 1996). It is also reported that anxiety correlated negatively with rectal mucosal blood flow (Emmanuel et al, 2001). Anxiety is reported to facilitate antral meal retention (Lorena et al, 2004).…”

Section: Correlation Of Both Anxiety and Depression Scores And The Lfmentioning

confidence: 99%

Correlations between the responses of electrogastrograms, heart rate and respiratory rate to the stress of the mirror drawing test in human subjects

Homma

2006

J. Smooth Muscle Res.

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Original C o r r e l a t i o n s b e t w e e n t h e r e s p o n s e s o felectrogastrograms, heart rate and respiratory rate to the stress of the mirror drawing test in human subjects AbstractAn electrogastrogram (EGG) recorded on the skin is believed to reflect the electrical activity of the gastrointestinal tract. In this study, linear correlations were calculated for the EGG spectral frequencies and the power ratios, changes in heart and respiratory rate before and during mirror drawing test (MDT) stress and after having meals, with the changes in the sympathetic tone indicator (LF/HF) and HADS anxiety and depression scores in human subjects (n=48). Depression scores had a negative linear correlation with the EGG resting frequencies of the epigastric and supraumbilical 6 cpm groups (5.0-7.4 cpm). Anxiety scores had a positive linear correlation with the EGG area power ratio of the resting to MDT stress responses of the epigastric and infraumbilical 6 cpm groups (6 cpm area during MDT/that during fasting rest). The resting LF/HF had a positive linear correlation with the EGG area power ratio of the resting to MDT stress responses of the epigastric and infraumbilical 3 cpm groups (2.5-4.9 cpm). The resting LF/HF ratio had a negative correlation with the area power ratio of the resting to postprandial responses (postprandial power/resting power) in the epigatric, supraumbilical and infraumbilical 6 cpm groups. The resting LF/HF ratio had a positive linear correlation with the heart rate at rest and during MDT-stress. In contrast, the resting LF/HF ratio had a negative linear correlation with the respiratory rate at rest and during MDT-stress. EGGs of the surface electrical activities of the gastrointestinal tract were influenced by acute MDT-stress and their frequencies and their response power ratios were correlated linearly with anxiety scores, depression scores and the sympathetic tone indicator, the LF/HF ratio.

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“…For example, chronic levels of anxiety and depression are associated with altered activity of the autonomic innervation to the gut measured as rectal mucosal blood flow in women with idiopathic constipation [24]. Further, depression [25,26] and anxiety disorders [27] have been associated with autonomic dysfunction, although the results are divergent.…”

Section: Introductionmentioning

confidence: 98%

Autonomic Function at Rest and in Response to Emotional and Rectal Stimuli in Women with Irritable Bowel Syndrome

et al. 2007

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Our aim was to study autonomic function in patients with Irritable bowel syndrome (IBS) without constipation and psychiatric comorbidity. Respiratory sinus arrhythmia (RSA) (representing cardiac vagal activity), skin conductance (representing sympathetic activity) and heart rate were measured at baseline and as a response to emotional stress and rectal discomfort in 33 women with IBS and 21 healthy women. Baseline heart rate was higher in the patients than in the healthy volunteers. Both groups had decreased RSA and increased heart rate and skin conductance level when exposed to emotional stress, but the autonomic responses did not differ significantly between the groups. At discomfort threshold the patients had increased heart rate response and skin conductance amplitude when compared to the healthy volunteers. Correlations between autonomic responses and the depression subscale of the Hospital Anxiety and Depression (HAD) score differed markedly between the diarrhea-predominant IBS patients and the IBS patients with alternating stool habits.

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Relationship between psychological state and level of activity of extrinsic gut innervation in patients with a functional gut disorder

Cited by 57 publications

References 35 publications

Visceral hypersensitivity following cold water intake in subjects with irritable bowel syndrome

Visceral hypersensitivity following cold water intake in subjects with irritable bowel syndrome

Correlations between the responses of electrogastrograms, heart rate and respiratory rate to the stress of the mirror drawing test in human subjects

Autonomic Function at Rest and in Response to Emotional and Rectal Stimuli in Women with Irritable Bowel Syndrome

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