Relationship between prognostic factors of breast cancer and 99mTc-sestamibi uptake in patients who underwent scintimammography: Multivariate analysis of causes of false-negative results

Prognostic value of semi-quantitative tumor uptake on Tc-99m sestamibi breast-specific gamma imaging in invasive ductal breast cancer

“…Some authors reported significant correlations between the level of BSGI uptake and histologic biomarkers [8,[11][12][13][14]. Our results also demonstrated positive correlations for TNR with diverse histologic factors.…”

“…This patient had a recurrence in lung and lymph nodes after 6.8 months in breast cancer. A previous study reported a positive relationship between tumor markers and tumor-to-background ratio (TBR) on BSGI [8], and we expected similar results.…”

“…A positive correlation of TNR with tumor size indicates that high mitochondrial activity of a tumor is one of the important molecular mechanisms of tumor growth and local progression. A significant relationship between TNR and tumor size has been reported by other groups [8,11]. High TNR was also significantly correlated with positive axillary nodal status.…”

“…Our results suggested that higher tumor grade is significantly associated with higher TNR. Similarly, several studies also reported a positive correlation of tumor-to-background ratio with tumor grade [8,12].…”

“…Biological information on breast cancer is important for predicting prognosis and is mainly estimated by pathologic procedures. A few studies have reported a correlation between Tc-99m sestamibi uptake and histologic prognostic factors of breast cancer [7,8]. The prognostic value of Tc-99m sestamibi washout rate from breast cancer cells for predicting responses to neoadjuvant chemotherapy has been investigated based on its relationship with P-glycoprotein (Pgp) expression [9].…”