Relationship between platelet volume indices with macrovascular and peripheral neuropathy complications in type 2 diabetic patients (2型糖尿病患者血小板容积参数与大血管及外周神经并发症的相关性研究)

Xiao, Wenjin; Huang, Yun; Ji-xiang, Dong; Zhang, Xiaoyan; Hu, Ji

doi:10.1111/1753-0407.12104

Cited by 9 publications

(10 citation statements)

References 36 publications

(72 reference statements)

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“…Secondary risk factors are smoking and prediabetes [1,21,60,63]. Platelet activation [79][80][81][82], oxidative stress [65][66][67][68][69][70][71][72][73][74], low vitamin D [83,84], insulin resistance [58], and genetic factors [100][101][102][103][104][105][106] play another supplementary role, but, for the time being, there are limited options for intervention. A suggestion for targeting insulin resistance originates from the study by Pop-Busui et al, showing that reduced incident DSPN is less frequent in T2D patients receiving insulin-sensitizing oral agents (66%) than in those receiving insulinproviding treatment (66% vs. 72%, respectively, p = 0.02) [155].…”

Section: Discussionmentioning

confidence: 99%

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Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

2015

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■ AbstractDistal symmetric sensorimotor polyneuropathy (DSPN) is the most common neurological manifestation in diabetes. Major risk factors of DSPN include diabetes duration, hyperglycemia, and age, followed by prediabetes, hypertension, dyslipidemia, and obesity. Height, smoking, insulin resistance, hypoinsulinemia, and others represent an additional risk. Importantly, hyperglycemia, hypertension, dyslipidemia, obesity, and smoking are modifiable. Stringent glycemic control has been shown to be effective in type 1, but not to the same extent in type 2 diabetes. Antilipidemic treatment, especially with fenofibrate, and multi-factorial intervention have produced encouraging results, but more experience is necessary. The major comorbidities of DSPN are depression, autonomic neuropathy, peripheral artery disease, cardiovascular disease, nephropathy, retinopathy, and medial arterial calcification. Knowledge of risk factors and comorbidities has the potential to enrich the therapeutic strategy in clinical practice as part of the overall medical care for patients with neuropathy. This article provides an updated overview of DSPN risk factors and comorbidities.

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Section: Discussionmentioning

confidence: 99%

“…Mean platelet volume (MPV) is a marker of platelet activation, and may be increased in diabetes patients, especially in the context of microvascular complications [80]. Elevated MPV has indeed been reported in T2D patients with DSPN [81,82].…”

Section: Platelet Activationmentioning

confidence: 99%

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

2015

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“…Increased MPV has been demonstrated in diabetes (3)(4)(5)(6)(7)(8)(9). There are conflicting results about the relation of MPV with diabetic nephropathy/microalbuminuria (MA) (10)(11)(12)(13)(14)(15)(16)(17), diabetic neuropathy (18)(19)(20), coronary artery disease (4,13,18,(21)(22)(23)(24)(25), and cerebrovascular disease (3)(4)(5)26) in diabetic patients. Large platelets may play a role in the development of vascular damage in DR by being more active, forcing 2012.…”

Section: Introductionmentioning

confidence: 99%

The relationship of mean platelet volume with retinopathy in type 2 diabetes mellitus

Güngör¹,

Gürsoy

Güngör³

et al. 2016

Turk J Med Sci

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IntroductionDiabetes mellitus (DM), a major global health problem, is commonly associated with increased risk of developing micro-and macrovascular disease. Despite its clinical importance, the pathophysiology of diabetic complications is not completely understood. Platelets have been thought to be involved in these complications. Diabetic retinopathy (DR) is one of those important complications and leads to a considerable increase in morbidity.Platelet volume is a marker of platelet activation and function that can be measured easily as mean platelet volume (MPV) by clinical analyzers. It is now known that larger platelets are more reactive and produce more prothrombotic factors (1,2). Increased MPV has been demonstrated in diabetes (3-9). There are conflicting results about the relation of MPV with diabetic nephropathy/microalbuminuria (MA) (10-17), diabetic neuropathy (18-20), coronary artery disease (4,13,18,(21)(22)(23)(24)(25), and cerebrovascular disease (3-5,26) in diabetic patients. Large platelets may play a role in the development of vascular damage in DR by being more active, forcing the production of more prothrombotic factors, or causing endothelium-dependent vasomotor dysfunction.Keeping in mind these complex relations between MPV, diabetes, and its complications, in the present study we aimed to: 1) compare the MPV in diabetic patients with that in healthy controls; 2) determine if there is a difference in MPV between diabetic patients with and without DR, and also with and without proliferative retinopathy; 3) compare MPV levels of diabetic patients with or without hypertension (HTA), hyperlipemia (HL), and HTA with HL, and 4) see if there is a correlation of MPV with HbA1c and body mass index (BMI) in diabetic patients. Material and methods PatientsA total of 102 type 2 DM (T2DM) patients [65 female (63.7%), 35 male (36.3%)], 50 of them without retinopathy [31 female (62.0%), 19 male (38.0%)] and 52 with retinopathy [34 female (65.4%), 18 male (34.6%)], aged 22-90 years, were recruited from the Clinic of Ankara Education and Research Hospital from June 2009 to June Background/aim: Patients with diabetes mellitus have an increased risk of developing micro-and macrovascular complications. Retinopathy is one of the most important complications of diabetes whose pathophysiological cause has not yet been determined. One candidate may be platelet volume. In this study we aimed to investigate the association between mean platelet volume and diabetic retinopathy.Materials and methods: Mean platelet volume levels were investigated in type 2 diabetic patients with and without retinopathy, and in healthy participants. After reclassifying our diabetics in terms of the presence or absence of hypertension and hyperlipidemia, we compared their mean platelet volumes. We then checked to see if the mean platelet volume correlated with hemoglobin A1c and body mass index. Results:The mean platelet volume levels were higher in all diabetic patients, and they were highest in diabetics with retinopathy. The mean plate...

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“…Many studies have shown that MPV, PCT, PDW, and P-LCR levels are higher in diabetics than in non-diabetic individuals (22)(23)(24) . Several authors have also suggested that increased MPV and PDW are associated with the presence of diabetes-related complications in T2DM patients (24)(25)(26) . On the other hand, it has been observed that platelet indices tend to decrease in patients with good glycemic control (5,27,28) .…”

Section: Discussionmentioning

confidence: 99%

Relationships Between Glycemic Control and Platelet Indices, Atherogenic Index of Plasma and Vitamin D in Patients with Type 2 Diabetes

Çakırca¹,

Çelik²

2019

ejcm

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Vitamin D deficiency, increased platelet indices and abnormal lipid profile are closely associated with increased vascular complications in type 2 diabetes mellitus (T2DM) patients. We investigated the relationship between glycemic control and platelet indices, vitamin D, atherogenic index of plasma (AIP) and other lipid components in T2DM patients. Materials and Methods: Diabetic subjects were divided into the groups 1 (good glycemic control, n=59 patients), 2 (moderate glycemic control, n=71 patients), and 3 (poor glycemic control, n=95 patients) according to the HbA1c levels of <7%, 7-9%, and >9%, respectively. We retrospectively analyzed serum lipid profile, platelet count, platelet indices, calcium, phosphorus, vitamin D and HbA1c levels in all patients. The AIP values of the subjects were calculated as follows: AIP=[log triglyceride/high density lipoprotein cholesterol (HDLc)]. Results: In group 1, the mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (P-LCR), triglyceride and AIP levels were lower, and the HDLc levels were higher than in group 3. Platelet indices, lipid profile, and AIP values of group 2 did not differ from those of group 1 or group 3. There was no difference among the three groups in terms of vitamin D levels. HBA1c levels were positively correlated with the duration of diabetes, triglycerides, AIP, PDW, MPV, and P-LCR, and negatively correlated with HDLc. Results: Increased platelet indices (MPV, PDW and P-LCR) and AIP values were observed in poor glycemic controlled diabetics. Accordingly, these parameters may be helpful in assessing increased cardiovascular risk in diabetics.

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Relationship between platelet volume indices with macrovascular and peripheral neuropathy complications in type 2 diabetic patients (2型糖尿病患者血小板容积参数与大血管及外周神经并发症的相关性研究)

Abstract: These findings implied the predictive value of platelets volume indices in vascular and peripheral neuropathy complications in type 2 diabetes.

Cited by 9 publications

References 36 publications

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

The relationship of mean platelet volume with retinopathy in type 2 diabetes mellitus

Relationships Between Glycemic Control and Platelet Indices, Atherogenic Index of Plasma and Vitamin D in Patients with Type 2 Diabetes

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