IntroductionDiabetes mellitus (DM), a major global health problem, is commonly associated with increased risk of developing micro-and macrovascular disease. Despite its clinical importance, the pathophysiology of diabetic complications is not completely understood. Platelets have been thought to be involved in these complications. Diabetic retinopathy (DR) is one of those important complications and leads to a considerable increase in morbidity.Platelet volume is a marker of platelet activation and function that can be measured easily as mean platelet volume (MPV) by clinical analyzers. It is now known that larger platelets are more reactive and produce more prothrombotic factors (1,2). Increased MPV has been demonstrated in diabetes (3-9). There are conflicting results about the relation of MPV with diabetic nephropathy/microalbuminuria (MA) (10-17), diabetic neuropathy (18-20), coronary artery disease (4,13,18,(21)(22)(23)(24)(25), and cerebrovascular disease (3-5,26) in diabetic patients. Large platelets may play a role in the development of vascular damage in DR by being more active, forcing the production of more prothrombotic factors, or causing endothelium-dependent vasomotor dysfunction.Keeping in mind these complex relations between MPV, diabetes, and its complications, in the present study we aimed to: 1) compare the MPV in diabetic patients with that in healthy controls; 2) determine if there is a difference in MPV between diabetic patients with and without DR, and also with and without proliferative retinopathy; 3) compare MPV levels of diabetic patients with or without hypertension (HTA), hyperlipemia (HL), and HTA with HL, and 4) see if there is a correlation of MPV with HbA1c and body mass index (BMI) in diabetic patients. Material and methods PatientsA total of 102 type 2 DM (T2DM) patients [65 female (63.7%), 35 male (36.3%)], 50 of them without retinopathy [31 female (62.0%), 19 male (38.0%)] and 52 with retinopathy [34 female (65.4%), 18 male (34.6%)], aged 22-90 years, were recruited from the Clinic of Ankara Education and Research Hospital from June 2009 to June Background/aim: Patients with diabetes mellitus have an increased risk of developing micro-and macrovascular complications. Retinopathy is one of the most important complications of diabetes whose pathophysiological cause has not yet been determined. One candidate may be platelet volume. In this study we aimed to investigate the association between mean platelet volume and diabetic retinopathy.Materials and methods: Mean platelet volume levels were investigated in type 2 diabetic patients with and without retinopathy, and in healthy participants. After reclassifying our diabetics in terms of the presence or absence of hypertension and hyperlipidemia, we compared their mean platelet volumes. We then checked to see if the mean platelet volume correlated with hemoglobin A1c and body mass index. Results:The mean platelet volume levels were higher in all diabetic patients, and they were highest in diabetics with retinopathy. The mean plate...

Mean platelet volume values of diabetic patients were higher than those of nondiabetics, the highest levels being in diabetics with microalbuminuria. Our results suggest that microalbuminuria might be related with mean platelet volume in diabetic patients.

A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Patients with diabetes mellitus have an increased risk of developing complications such as retinopathy and neuropathy. Size of platelets and inflammation have been suggested to be involved in the pathogenesis of diabetic complications. The purpose of this study was to find out if there was a correlation of mean platelet volume with inflammatory markers in patients with diabetes and retinopathy or neuropathy. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The study has been carried out on 50 patients with type 2 diabetes without retinopathy or neuropathy, 52 with retinopathy, and 50 with neuropathy, and 50 healthy participants. After comparing all the parameters we seeked correlation of mean platelet volume with inflammation markers in all groups. R Re es su ul lt ts s: : In diabetic group with retinopathy or neuropathy mean platelet volume levels were higher than patients with diabetes without those complications and the controls. We did not find any correlation between mean platelet volume and leucocyte count, sedimentation rate and high sensitivity C-reactive protein in all the groups. C Co on nc cl lu us si io on n: : The mean platelet volume values of patients with diabetes were higher than individuals without diabetes, highest levels being in patients with diabetes with retinopathy and neuropathy. We do not think that there is a link between mean platelet volume and inflammation in patients with diabetes with or without retinopathy or neuropathy at least in our patients.K Ke ey y W Wo or rd ds s: : Diabetes mellitus, type 2; diabetic retinopathy; diabetic neuropathies; blood platelets; inflammation Ö ÖZ ZE ET T A Am ma aç ç: : Diabetes mellituslu hastalar retinopati ve nöropati gibi komplikasyonları geliştirme riski altındadırlar. Trombosit boyutları ve inflamasyonun diyabetik komplikasyonların patogenezinde yer aldığı düşünülmektedir. Çalışmamızın amacı, retinopati veya nöropatisi olan diyabetli hastalarda ortalama trombosit volümü ile inflamatuar belirteçlerin arasında ilişki olup olmadığını saptamaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmamız retinopati veya nöropatisi olmayan 50 tip 2 diyabetli hasta, 52 retinopati, 50 nöropatisi olan tip 2 diyabetli hasta ve 50 sağlıklı kişi ile gerçekleştirilmi-ştir. Tüm gruplarda bütün parametreler kıyaslandıktan sonra ortalama trombosit volümü ile inflamatuar belirteçlerin arasında korelasyon olup olmadığı araştırılmıştır. B Bu ul lg gu ul la ar r: : Retinopati veya nöropatisi olan diyabetli hasta gruplarında ortalama trombosit volümü, komplikasyonları olmayan diyabetikler ve kontrollerden daha yüksekti. Tüm gruplarda ortalama trombosit volümü ile lökosit sayımı, sedimantasyon ve yüksek sensitivite C-reaktif protein değerleri arasında korelasyon saptanmadı. S So on nu uç ç: : Diyabetli hastalarda ortalama trombosit volümü non-diyabetiklerden yüksekti, en yüksek değerler retinopati ve nöropatisi olan diyabetli hastalarda idi. Retinopati ve nöropatisi olan ve olmayan diyabet...

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