Relationship Between Plasma Copper Concentration and Body Fat Distribution in Children in China: a Cross-Sectional Study

Liang, Jingjing; Chen, Fengyan; Fang, Guoqing; Zhang, Xin; Li, Yan; Ma, Bingjie; Lin, Song; Pan, Jialiang; Zhang, Zheqing

doi:10.1007/s12011-020-02105-y

Cited by 7 publications

(6 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a Korean study (n = 1896), higher serum Zn was directly associated with increased waist circumference (WC) and body fat (measured by dual-energy X-ray absorptiometry (DEXA)) in men but not in women [11]. Similar associations were found for serum Cu in studies in US adults (n = 7285) [12] and in Chinese children (n = 454) [13].…”

Section: Introductionmentioning

confidence: 60%

Association of Plasma Zinc and Copper with Body Composition, Lipids and Inflammation in a Cross-Sectional General Population Sample from Germany

Övermöhle,

Rimbach,

Waniek

et al. 2023

Nutrients

View full text Add to dashboard Cite

We aimed to relate circulating plasma zinc and copper to a broad spectrum of adiposity-related traits in a cross-sectional Northern German study (n = 841, 42% female, age: 61 ± 12 years). Zinc and copper were measured by inductively coupled plasma–mass spectrometry. Subcutaneous (SAT) and visceral (VAT) adipose tissue and liver fat were derived from 534 and 538 participants, respectively, via magnet resonance imaging. Associations were assessed using multivariable-adjusted linear regression analysis. An increase per one standard deviation (SD) in zinc was associated with direct linear increases in body mass index (BMI) (1.17%; 95% confidence interval (95%CI) 0.15–2.20%), waist circumference (0.85%; 95%CI 0.04–1.67%) and waist-to-hip ratio (0.64%; 95%CI 0.18–1.09%). A 1-SD increment in copper was directly associated with BMI (1.64%; 0.41–2.88%) and waist circumference (1.22%; 95%CI 0.25–2.20%) but not waist-to-hip ratio. Independent of fat intake, zinc displayed associations with VAT (5.73%; 95%CI 2.04–9.56%) and with liver fat (3.84%; 95%CI 1.49–6.25%), the latter association being also independent of BMI. Copper was directly associated with SAT (4.64%; 95%CI 0.31–9.15%) before accounting for BMI, but showed no association with VAT or liver fat. Observed associations suggest a possible relevance of zinc and copper to adiposity. Particularly zinc displayed associations with traits of abdominal adiposity and liver fat.

show abstract

Section: Introductionmentioning

confidence: 60%

Association of Plasma Zinc and Copper with Body Composition, Lipids and Inflammation in a Cross-Sectional General Population Sample from Germany

Övermöhle,

Rimbach,

Waniek

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

“…There are conflicting data on the levels of serum and liver copper observed in NAFLD patients. Although low levels of copper have been described in the serum of NAFLD patients [52][53][54], copper ions have also been described to increase through cirrhosis to HCC, in MetS and in obese patients, in whose it plays an important role in the accumulation of fat in adipose tissue [28,55,56]. The discrepancy between the literature data may be due to several issues, i.e.…”

Section: Discussionmentioning

confidence: 98%

Copper-catalyzed dicarbonyl stress in NAFLD mice: protective effects of Oleuropein treatment on liver damage

et al. 2022

View full text Add to dashboard Cite

Background Nonalcoholic fatty liver disease (NAFLD) or more appropriately, metabolic associated fatty liver disease (MAFLD), is the hepatic manifestation of metabolic syndrome. An imbalance of copper homeostasis has been described in the progression of NAFLD/MAFLD toward NASH/MASH. We were interested in understanding whether the chelating activity of Oleuropein (Ole) was able to improve the copper accumulation and the related pro-oxidant and glycative damage in the liver of mice fed HFD. Methods Twelve C57BL/6J mice fed normal diet (ND) or high-fat diet (HFD) for 16 weeks and then thirty two female and male mice fed ND or HFD for 8 weeks adding Ole for the following 8 weeks were studied. Results Altered expression of copper-trafficking genes and proteins (CTR1, CTR2, ATP7B, COX17, CCS, and ATOX1) induced imbalance of copper homeostasis combined with an increase in dicarbonyl stress in the liver of HFD fed mice. Interestingly enough, glyoxalase system was improved by Ole administration and the Ole related protective effects differ in the two sexes of mice. Conclusions Our study highlights the role of the dicarbonyl stress in the pathogenesis of NAFLD and suggests Ole as a natural copper chelator to prevent the liver damage induced by methyglyoxal pathway derangement.

show abstract

“…This cross-sectional study was performed in Guangdong province in the south of China in 2015–2017 (29) . The investigators recruited healthy children aged 6–9 years from several kindergartens and primary schools.…”

Section: Methodsmentioning

confidence: 99%

Associations of plasma retinol and α-tocopherol levels with skeletal muscle health in Chinese children

et al. 2023

Self Cite

View full text Add to dashboard Cite

Childhood is a critical period for muscle accumulation. Studies in elders have reported that antioxidant vitamins could improve muscle health. However, limited studies have assessed such associations in children. This study included 243 boys and 183 girls. A 79-item food frequency questionnaire was used to investigate dietary nutrients intake. Plasma levels of retinol and α-tocopherol were measured using high-performance liquid chromatography with mass spectrometry. Dual X-ray absorptiometry was used to assess appendicular skeletal muscle mass (ASM) and total body fat. The ASM index (ASMI) and ASMI Z-score were then calculated. Hand grip strength (HGS) was measured using a Jamar® Plus+ Hand Dynamometer. Fully adjusted multiple linear regression models showed that for each unit increase in plasma retinol content, ASM, ASMI, left HGS, and ASMI Z-score increased by 2.43 × 10-3 kg, 1.33 × 10-3 kg/m2, 3.72 × 10-3 kg, and 2.45 × 10-3 in girls, respectively (P < 0.001–0.050). Analysis of covariance revealed a dose-response relationship between tertiles of plasma retinol level and muscle indicators (P-trend: 0.001–0.007). The percentage differences between the top and bottom tertiles were 8.38%, 6.26%, 13.2%, 12.1% and 116% for ASM, ASMI, left HGS, right HGS, and ASMI Z-score in girls, respectively (P-diff: 0.005–0.020). No such associations were observed in boys. Plasma α-tocopherol levels were not correlated with muscle indicators in either sex. In conclusion, high circulating retinol levels are positively associated with muscle mass and strength in school-age girls.

show abstract

Relationship Between Plasma Copper Concentration and Body Fat Distribution in Children in China: a Cross-Sectional Study

Cited by 7 publications

References 40 publications

Association of Plasma Zinc and Copper with Body Composition, Lipids and Inflammation in a Cross-Sectional General Population Sample from Germany

Association of Plasma Zinc and Copper with Body Composition, Lipids and Inflammation in a Cross-Sectional General Population Sample from Germany

Copper-catalyzed dicarbonyl stress in NAFLD mice: protective effects of Oleuropein treatment on liver damage

Associations of plasma retinol and α-tocopherol levels with skeletal muscle health in Chinese children

Contact Info

Product

Resources

About