“…For the determination of the pharmacokinetic parameters of cefroxadine in biological samples, microbial assays or high pressure liquid chromatography (HPLC) has been used in a number of studies [4][5][6][7][8][9][10][11]. Most of the HPLC methods reported previously are mainly based on the method developed by Lecaillon et al [5,8,9,11,12]. Although the HPLC method was more accurate and precise than microbiological determination, the peaks were not well resolved and had slow retention times.…”