Relationship between personality trait and regional cerebral glucose metabolism assessed with positron emission tomography

Youn, Tae Jin; Lyoo, In Kyoon; Kim, Jae Jin; Park, Hae Jeong; Ha, Kotdaji; Lee, Dong Hoon; Abrams, Kelley Yost; Lee, Myung Chul; Kwon, Jun Soo

doi:10.1016/s0301-0511(02)00047-9

Cited by 59 publications

(31 citation statements)

References 40 publications

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“…This is consistent with our results, because a greater hemodynamic response might be regarded as the consequence of enhanced activation and slow recovery of the motor cortex. Although our hypothesis does not seem to be consistent with a previous PET study in which reduced metabolism of the motor cortex during the resting state was observed in high NS subjects [35] , the apparent discrepancy might be explained by the difference in the experimental paradigms, in that their study focused on the resting state whereas we focused on the activated state, or by the difference in the experimental modality, in that they measured blood flow or metabolism during comparatively long periods while we measured electrophysiological activities in the millisecond to second time frame.…”

Section: Discussioncontrasting

confidence: 98%

Enhanced Reactivity and Delayed Recovery of Sensorimotor Cortex in the Novelty Seeking Personality

Shishida

Hashizume²,

Onoda³

et al. 2006

Neuropsychobiology

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Background: The novelty seeking (NS) personality trait is hypothesized to be associated with high cortical reactivity, poor inhibitory control and/or varied dopaminergic neurotransmission in the basal ganglia. After somatosensory stimulation, electrical oscillations in alpha and beta bands generated in the sensorimotor cortex show a short duration decrease (event-related desynchronization) and a subsequent increase (event-related synchronization) that is thought to reflect cortical activation and the inhibitory/recovery process, respectively. These oscillatory changes are also believed to be affected by the status of the basal ganglia and by dopaminergic functions. In the present study, we investigated the association between the NS personality trait and somatosensory oscillatory changes after median nerve stimulation assessed by magnetoencephalography. Methods: From 48 healthy subjects, we selected 14 high scorers and 14 age- and sex-matched low scorers on the NS dimension of the Temperament and Character Inventory. Magnetic fields were recorded while subjects received electrical stimulation of either the right or left median nerve with equal probability and with a randomized interstimulus interval. Frequency analysis was performed on the alpha and beta bands. Results: Compared with the low NS group, the high NS group showed larger magnitude of beta event-related desynchronization and larger latencies of the alpha and beta event-related synchronization. Conclusion: These results suggest that individuals with high degrees of the NS trait have greater reactivity and delayed recovery of the sensorimotor cortex in response to simple somatosensory stimulation. This may be significant for the understanding of their exploratory and impulsive behavior.

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Section: Discussioncontrasting

confidence: 98%

Enhanced Reactivity and Delayed Recovery of Sensorimotor Cortex in the Novelty Seeking Personality

Shishida

Hashizume²,

Onoda³

et al. 2006

Neuropsychobiology

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“…Past research has shown that differences in personality traits can also be linked to brain structure and function at rest as measured by structural magnetic resonance imaging (MRI), functional MRI (fMRI), and fluorodeoxyglucose positron emission tomography (FDG-PET) [10,11,12,13,14,15,16,17,18,19]. Personality traits have also been shown to influence task-elicited brain function, as demonstrated by imaging studies using emotionally valenced tasks [20,21,22,23,24,25].…”

Section: Introductionmentioning

confidence: 99%

A Preliminary Study of the Opioid System and Personality Traits Using Positron Emission Tomography

et al. 2017

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Background: Personality traits, such as Neuroticism and Extraversion, have been implicated in the processing of emotion. The neural correlates most often associated with Neuroticism and Extraversion are the insular cortex, orbitofrontal cortex, amygdala, and ventral striatum. Objective: The aim of the current study was to explore neurotransmitter systems underlying those neural correlates and investigate the relationship between personality traits and opioid receptor binding potential. Method: Twelve healthy participants completed an [11C]diprenorphine positron emission tomography scan at rest. Endogenous opioid levels as indicated by opioid receptor binding potential was examined in relation to personality phenotype. Results: A high score of Neuroticism, a personality trait characterized by negative affect, was found to be associated with high opioid receptor binding in the right anterior insula. Conversely, a high score of Extraversion, a personality trait characterized by positive affect, was found to be associated with low opioid receptor binding in the left posterior insula. Conclusions: While preliminary, the results of this study suggest that the expression of Neuroticism and Extraversion is related to baseline function of the opioid neurotransmitter system in the insular cortex. These findings may help elucidate the neural mechanisms underlying the expression of personality traits, particularly those implicated in affective processing.

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“…Gardini et al [16] suggested that individual differences in the temperament dimensions might reflect structural variance in specific brain areas. Youn et al [18] reported that NS is primarily correlated with the activities of the substantia nigra and several temporal regions and that HA and reward dependence (RD) were primarily correlated with the activities of the temporal lobe and orbitofrontal gyrus in a positron emission tomography (PET) study. One functional magnetic resonance imaging (fMRI) study demonstrated that blood oxygen level dependent (BOLD) signals are correlated with scores on various personality scales, and these signals suggest that variations in personality traits might partially account for variations in the neural responses of particular brain regions [19].…”

Section: Stimuli and Taskmentioning

confidence: 99%

Functional Associations of Temperamental Predisposition and Brain Responses While Processing Stressful Word Stimuli Related to Interpersonal Relationships in Bulimia Nervosa Patients: an fMRI Study

Miyake¹,

Okamoto²,

Onoda³

et al. 2016

J Neuroimaging Psychiatry Neurol

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Bulimia nervosa (BN) is characterized by frequent episodes of uncontrolled overeating and difficulties in adapting to stressful situations. BN patients tend to be sensitive to frustration and impulsive. Personality traits may be associated with the abilities of BN patients to adapt to stressful situations, especially in interpersonal relationships. The aim of the present study was to investigate the functional abnormalities in various brain systems while processing stressful word stimuli related to interpersonal relationships in BN patients. Functional magnetic resonance imaging was used to examine the brain responses of 15 BN patients and 20 healthy women while processing unpleasant words related to interpersonal relationships. We also investigated the relationships between brain responses and temperament trait scale from the Temperament and Character Inventory. BN patients showed significant activations of medial prefrontal cortex and anterior cingulate cortex (ACC) while processing these words. ACC activation was significantly greater in BN patients than in healthy women. Among BN patients, the score of the harm avoidance was positively correlated with the activation of the ACC, and the score of the novelty seeking was negatively correlated with the activations in the left inferior frontal gyrus (IFC) and the insula. These results suggest that ACC activation may play crucial roles in emotional processing impairments of BN. Reduced activations of IFC and insula while processing stressful words may reflect a general failure of self-regulation. These abnormal functional responses to stressful stimuli may be involved in difficulties in adapting to stressful situations in BN patients.

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Relationship between personality trait and regional cerebral glucose metabolism assessed with positron emission tomography

Cited by 59 publications

References 40 publications

Enhanced Reactivity and Delayed Recovery of Sensorimotor Cortex in the Novelty Seeking Personality

Enhanced Reactivity and Delayed Recovery of Sensorimotor Cortex in the Novelty Seeking Personality

A Preliminary Study of the Opioid System and Personality Traits Using Positron Emission Tomography

Functional Associations of Temperamental Predisposition and Brain Responses While Processing Stressful Word Stimuli Related to Interpersonal Relationships in Bulimia Nervosa Patients: an fMRI Study

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