A Preliminary Study of the Opioid System and Personality Traits Using Positron Emission Tomography

Rodman, Alexandra M.; Deckersbach, Thilo; Chou, Tina; Kong, Jian; Gollub, Randy L.; Dougherty, Darin D.

doi:10.1159/000452417

Cited by 4 publications

(4 citation statements)

References 46 publications

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“…These findings are congruent with neuropsychological data indicating that neuroticism is linked to a negative bias in attention, a negative bias in interpretation and recall of information, as well as increased reactivity and poor coping 41 . Neuroticism has also been linked to increased opioid receptor binding in the right anterior insula 42 . Links to fronto-amygdala activity in harm avoidance have also been noted 43 …”

Section: Resultssupporting

confidence: 78%

“…41 Neuroticism has also been linked to increased opioid receptor binding in the right anterior insula. 42 Links to frontoamygdala activity in harm avoidance have also been noted. 43,44 fMRI work on avoidance in healthy adults found increased activation of the nucleus accumbens (NAcc) in active avoidance and enhanced deactivation during passive avoidance.…”

Section: Neuroimagingmentioning

confidence: 95%

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The neurobiology of obsessive–compulsive personality disorder: a systematic review

2021

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Background A number of recent investigations have focused on the neurobiology of obsessive–compulsive personality disorder (OCPD). However, there have been few reviews of this literature with no detailed model proposed. We therefore undertook a systematic review of these investigations, aiming to map the available evidence and investigate whether it is possible to formulate a detailed model of the neurobiology of OCPD. Methods OCPD can be considered from both categorical and dimensional perspectives. An electronic search was therefore conducted using terms that would address not only OCPD as a category, but also related constructs, such as perfectionism, that would capture research on neuropsychology, neuroimaging, neurochemistry, and neurogenetics. Results A total of 1059 articles were retrieved, with 87 ultimately selected for abstract screening, resulting in a final selection of 49 articles focusing on neurobiological investigations relevant to OCPD. Impaired executive function and cognitive inflexibility are common neuropsychological traits in this condition, and suggest that obsessive–compulsive disorder (OCD) and OCPD may lie on a continuum. However, neuroimaging studies in OCPD indicate the involvement of specific neurocircuitry, including the precuneus and amygdala, and so suggest that OCD and OCPD may have important differences. Although OCPD has a heritable component, we found no well-powered genetic studies of OCPD. Conclusion Although knowledge in this area has advanced, there are insufficient data on which to base a comprehensive model of the neurobiology of OCPD. Given the clinical importance of OCPD, further work to understand the mechanisms that underpin this condition is warranted.

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Section: Resultssupporting

confidence: 78%

Section: Neuroimagingmentioning

confidence: 95%

The neurobiology of obsessive–compulsive personality disorder: a systematic review

2021

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“…In an American PET study with [ 11 C]DPN in 12 healthy subjects, a high score of neuroticism was found to be associated with high opioid receptor binding in the right anterior insula. On the other hand, a high score of extraversion was associated with low tracer binding in the left posterior insula (Rodman et al 2017).…”

Section: Personality Traitsmentioning

confidence: 91%

Positron Emission Tomography (PET) Imaging of Opioid Receptors

Waarde¹,

Absalom²,

Visser³

et al. 2020

PET and SPECT of Neurobiological Systems

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The opioid system consists of opioid receptors (which mediate the actions of opium), their endogenous ligands (the enkephalins, endorphins, endomorphins, dynorphin, and nociceptin), and the proteins involved in opioid production, transport, and degradation. PET tracers for the various opioid receptor subtypes are available, and changes in regional opioidergic activity have been assessed during both sensory and affective processing in healthy individuals and in various disease conditions such as chronic pain, neurodegeneration, epilepsy, eating disorders, behavioral addiction, and substance abuse. It is not always clear whether observed changes of tracer binding reflect altered release of endogenous opioids or altered opioid receptor expression. This issue may be resolved by studies in experimental animals that combine in vivo PET imaging with ex vivo immunohistochemistry. Some radioligands for opioid receptors have suboptimal kinetics (i.e., slow dissociation from their target protein) or can induce undesired side effects even at low administered doses (sedation, respiratory arrest). Yet, PET offers the unique opportunity of quantifying opioid receptor-mediated signaling in the living human brain. PET imaging has provided evidence for a link between opioid neurotransmission and peripheral immune activation.

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“…Genetic studies in conditions related to narcissism (e.g. antisocial or borderline personality disorders) (Caspi et al, 2008;Langley et al, 2010;Silberschmidt & Sponheim, 2008) and imaging studies on the relationship of monoamine or opiate receptor binding to dimensional personality measures (Breier et al, 1998;Caravaggio et al, 2017;Farde et al, 2018;Moresco et al, 2002;Rodman et al, 2017) have provided significant evidence for the existence of specific biological correlates of personality disorders and the quantitative expression of personality dimension. In order to explore new ways of thinking about narcissism, we searched for pharmacological models that could inform future research into the neurobiology of narcissism.…”

Section: Introductionmentioning

confidence: 99%

Addicted to Self-esteem: Understanding the neurochemistry of narcissism by using cocaine as a pharmacological model

Kastner-Bosek

Dajic

Mikuš

et al. 2021

Journal of Experimental Psychopathology

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There are pronounced behavioural and neuroimaging parallels between cocaine abuse and narcissism. Although the observed commonalities are not specific to cocaine as opposed to other types of addiction, we argue that the relatively constrained molecular actions of cocaine and, more importantly, the covariance of narcissism-like behaviours with cocaine use build a strong case for taking the known effects of cocaine as a starting point for addressing the hitherto underinvestigated neurophysiology of narcissism. In this review, we discuss the potential relevance of cocaine abuse as a pharmacological model of narcissism. We outline previous research on the role of monoamines across several domains affected in narcissistic personality disorder and subclinical narcissism, namely, selected personality traits, social behaviour, emotional empathy and self-referential processing. We propose that dysregulation in dopamine signalling might underlie addiction-like features of narcissism and that altered serotonergic signalling may account for affective components of narcissism and, in particular, explain the differences between grandiose and vulnerable subtypes. In conclusion, we provide recommendations for future research.

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A Preliminary Study of the Opioid System and Personality Traits Using Positron Emission Tomography

Cited by 4 publications

References 46 publications

The neurobiology of obsessive–compulsive personality disorder: a systematic review

The neurobiology of obsessive–compulsive personality disorder: a systematic review

Positron Emission Tomography (PET) Imaging of Opioid Receptors

Addicted to Self-esteem: Understanding the neurochemistry of narcissism by using cocaine as a pharmacological model

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