Relationship between periodontitis and hepatic abnormalities in young adults

Furuta, Michiko; Ekuni, Daisuke; Yamamoto, Tatsuo; Irie, Koichiro; Koyama, Reiko; Sanbe, Toshihiro; Yamanaka, Reiko; Morita, Manabu; Kuroki, Kenji; Tobe, Kazuo

doi:10.3109/00016350903291913

Cited by 55 publications

(50 citation statements)

References 30 publications

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“…Our results were similar to a previous study that demonstrated an association between hepatic abnormalities, defined by ALT ≥ 41 IU/L, and periodontal disease in young Japanese males (aged 18-19 years) who did not seem to consume alcohol due to Japanese law prohibiting alcohol consumption by those under 20 years of age (20). The present study extends the findings of the previous study by indicating an association between liver abnormalities and periodontal conditions in middle-aged males with both low alcohol consumption and MetS.…”

Section: Discussionsupporting

confidence: 81%

“…Studies to date (3,20) have not examined the association of MetS and hepatic abnormalities with periodontal disease. Recently, Morita et al (9) found that hepatic abnormalities were associated with periodontal disease regardless of alcohol consumption after adjusting for the components of MetS; we found no statistically significant association between elevated ALT and high PD values in males with high alcohol consumption.…”

Section: Discussionmentioning

confidence: 99%

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Association of periodontal status with liver abnormalities and metabolic syndrome

Ahmad

Furuta

Shinagawa³

et al. 2015

J Oral Sci

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Although an association between periodontal status and liver abnormalities has been reported, it has not been described in relation to metabolic syndrome (MetS), which often coexists with non-alcoholic fatty liver disease. We examined the association of a combination of liver abnormality and MetS with periodontal condition in Japanese adults, based on the level of alcohol consumption. In 2008, 4,207 males aged 45.4 ± 8.9 years and 1,270 females aged 45.9 ± 9.7 years had annual workplace health check-ups at a company in Japan. Periodontal status was represented as periodontal pocket depth at the mesio-buccal and mid-buccal sites for all teeth. Alanine aminotransferase (ALT), and metabolic components were examined. Multiple linear regression analysis showed a significant association between deep pocket depth and the coexistence of elevated ALT and MetS in males with low alcohol consumption. Females showed no such relationship. In conclusion, the association between periodontal condition and the combination of elevated ALT and MetS was confirmed in males. That is, a clear association between liver abnormalities and periodontal condition was seen in male subjects with no or low alcohol consumption and MetS, providing new insights into the connection between liver function and periodontal health. (J Oral Sci 57, 335-343, 2015)

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Association of periodontal status with liver abnormalities and metabolic syndrome

Ahmad

Furuta

Shinagawa³

et al. 2015

J Oral Sci

Self Cite

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“…The blood is carried into the liver via anchor lipid molecules, and it subsequently enters the systemic circulation to supply metabolic energy. Although NAFLD is characterized by the accumulation of both triglycerides and free cholesterol without a corresponding increase in CEs [36], elevated CE levels in the presence of systemic inflammation may play a biochemical role in cholesterol accumulation in the liver. This could also be exacerbated by inflammation due to unrelated inflammatory disease, although further studies are required to investigate the underlying mechanism.…”

Section: Discussionmentioning

confidence: 99%

Cholesterol-Induced Non-Alcoholic Fatty Liver Disease and Atherosclerosis Aggravated by Systemic Inflammation

Kim

Seo

et al. 2014

PLoS ONE

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Although triglyceride accumulation in the liver causes non-alcoholic fatty liver disease (NAFLD), hypercholesterolemia is also a main cause of NAFLD as well as atherosclerosis. However, NAFLD and atherosclerosis have not been investigated simultaneously in animal models fed a high-cholesterol diet. Moreover, it is unclear whether systemic inflammation can exacerbate both pathologies in the same model. Accordingly, this study investigated the effect of additional systemic inflammation on NAFLD and atherosclerosis induced by cholesterol overload in wild animals. New Zealand white rabbits were divided into 4 groups: groups I (control) and II received normal chow, and groups III and IV received a 1% cholesterol diet. To induce inflammation via toll-like receptor (TLR)-4 signaling, groups II and IV received subcutaneous injections of 0.5 mL of 1% carrageenan every 3 weeks. After 3 months, total cholesterol markedly increased in groups III and IV, and the serum expressions of systemic inflammatory markers were elevated in the groups II–IV. Early NAFLD lesions (e.g., mild fatty changes in the liver with sporadic fibrosis) and atherosclerosis (e.g., intimal hyperplasia composed of foam cells) were observed in both the liver and aorta specimens from group III, and advanced lesions were observed in group IV. The expressions of inflammatory cellular receptors, TLR-2 and TLR-4, in the aorta gradually increased from group I to IV but were similar in the liver in groups II–IV. Cholesteryl ester (CE) levels were higher in group IV than in group III, although the difference was not significant. CE levels in the aorta were similar between groups III and IV. Systemic inflammation can simultaneously exacerbate existing early lesions due to cholesterol overload in both the liver and aorta of rabbits. However, the cellular response of inflammatory receptors and expression of cholesterol metabolites differ between these organs.

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“…In a study conducted in a Japanese college, male students with a high level of serum ALT were identified to be significantly more likely to have periodontitis than those with a low level of serum ALT (21). As for females, the association between a higher ALT level and an increased risk of periodontitis was not found to be significant, which was in contrast to a previous study that indicated that the incidence rate of periodontitis in females aged 20–59 years was significantly increased with elevated serum levels of ALT (22).…”

Section: Periodontitis and Liver Diseasesmentioning

confidence: 99%

Interaction between periodontitis and liver diseases

2016

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Relationship between periodontitis and hepatic abnormalities in young adults

Abstract: Elevated ALT could be a potential risk indicator for periodontitis among young males. Monitoring hepatic abnormalities to prevent periodontitis must be better understood, even in the young adult population.

Cited by 55 publications

References 30 publications

Association of periodontal status with liver abnormalities and metabolic syndrome

Association of periodontal status with liver abnormalities and metabolic syndrome

Cholesterol-Induced Non-Alcoholic Fatty Liver Disease and Atherosclerosis Aggravated by Systemic Inflammation

Interaction between periodontitis and liver diseases

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