Association of periodontal status with liver abnormalities and metabolic syndrome

Abstract

Although an association between periodontal status and liver abnormalities has been reported, it has not been described in relation to metabolic syndrome (MetS), which often coexists with non-alcoholic fatty liver disease. We examined the association of a combination of liver abnormality and MetS with periodontal condition in Japanese adults, based on the level of alcohol consumption. In 2008, 4,207 males aged 45.4 ± 8.9 years and 1,270 females aged 45.9 ± 9.7 years had annual workplace health check-ups at a company in Japan. Periodontal status was represented as periodontal pocket depth at the mesio-buccal and mid-buccal sites for all teeth. Alanine aminotransferase (ALT), and metabolic components were examined. Multiple linear regression analysis showed a significant association between deep pocket depth and the coexistence of elevated ALT and MetS in males with low alcohol consumption. Females showed no such relationship. In conclusion, the association between periodontal condition and the combination of elevated ALT and MetS was confirmed in males. That is, a clear association between liver abnormalities and periodontal condition was seen in male subjects with no or low alcohol consumption and MetS, providing new insights into the connection between liver function and periodontal health. (J Oral Sci 57, 335-343, 2015)

Oral health as a gateway to overall health and well‐being: Surveillance of the geriatric population in the United States

“…Although still debated, long‐term use of asthma medication may put patients at risk for dental caries, dental erosion, and periodontitis . While it is important to consider behavioral patterns for an association between oral health outcome and liver disease, periodontitis has also been linked to liver abnormalities among males who consume little to no alcohol in the past as well . Indeed, diabetes may be acting as a confounding factor for the association between the oral health outcome, coronary heart disease, and congestive heart disease as diabetic patients have been found to be at higher risk of congenital heart disease, and congestive heart failure .…”

Relationship between clinical periodontal parameters and changes in liver enzymes levels over an 8‐year period in an elderly Japanese population

“…In the elderly population, it is important to reduce the risk of systemic disease by controlling risk factors at an early stage. A number of researchers have suggested that periodontal disease may be a risk factor for systemic diseases such as cardiovascular disease, rheumatoid arthritis and metabolic syndrome (Ahmad et al., ; Furuta et al., ; Hanindriyo, Yoshihara, Hirotomi, & Miyazaki, ; Iwasaki et al., ; Pussinen et al., ).…”

“…and metabolic syndrome (Ahmad et al, 2015;Furuta et al, 2016;Hanindriyo, Yoshihara, Hirotomi, & Miyazaki, 2013;Iwasaki et al, 2016;Pussinen et al, 2003).…”

Efficacy and safety of PERIOdontal treatment versus usual care for Nonalcoholic liver disease: protocol of the PERION multicenter, two-arm, open-label, randomized trial

“…In addition, the incidence of periodontal disease in healthy Japanese women was reported to be significantly increased with elevated serum levels of AST, ALT, and cholinesterase [38]. Furthermore, an observational study with annual workplace health check-ups at a company in Japan reported an association between periodontal condition and the combination of elevated ALT and metabolic syndrome (MetS) in men [39]. Besides, it has been suggested that more severe periodontal disease is associated with increased serum levels of GGT, a liver biochemical parameter, in Japanese adults with no alcohol-drinking habits [40].…”