Relationship between periodontal findings and specific polymorphisms of interleukin-1α and -1β in Turkish patients with Behçet’s disease

Abstract

Genetic factors predispose individuals to Behçet's disease (BD) and periodontal disease. IL-1 has been implicated in the pathogenesis of both BD and periodontal disease. The relationship between periodontitis and pathogenesis of BD has not yet been determined. Since IL-1 has been implicated in the pathogenesis of both BD and periodontal disease, we aimed to investigate the possible relation of the periodontal scores and SNPs of IL-1alpha-889C/T, IL-1beta-511C/T, and IL-1beta+3962T/C with BD compared to healthy controls (HC) and recurrent aphtous stomatitis (RAS). A total of 155 Turkish individuals were enrolled in this study. The periodontal status of all subjects was evaluated according to the WHO community periodontal index of treatment needs. For genotyping, CTS-PCR-SSP was employed. IL-1alpha-889C allele was significantly higher in BD patients (p = 0.03) and RAS (p = 0.02) compared to HC. The frequency of IL-1beta+3962T allele was significantly higher in RAS patients compared to HC (p = 0.015). Male gender (p = 0.04), age (p = 0.02) and carrying IL-1beta-511T allele (p = 0.01) were found to be a significant risk factors for higher periodontal scores in Turkish population. We can speculate that susceptibility to the development of periodontal disease could be influenced by IL-1 SNPs. Periodontitis-induced autoinflammatory response also may play a role in the development/severity of BD and RAS via IL-1 gene alteration.

Common MEFV gene mutations in Turkish patients with Behcet's disease

“…Pay et al demonstrated that, IL-1b level in synovial fluid is significantly higher in the BD patients than the OA (osteoarthritis) patients (Pay et al, 2006). Most recent studies showed that the Single Nucleotide Polymorphisms (SNPs) of IL1 are associated with the onset of BD (Akman et al, 2008;Coskun et al, 2005;Karasneh et al, 2003).…”

“…The major role of pyrin appears to be in the regulation of inflammation by increasing the IL-1b secretion (Chae et al, 2009). IL-1 is an important cytokine in BD (Akman et al, 2008;Coskun et al, 2005;Karasneh et al, 2003;Pay et al, 2006;Zhou et al, 2012). The important role of the pyrin on the regulation of IL-1b secretion supports the studies investigating of relationship between BD and MEFV mutations.…”

Etiopathogenesis of Recurrent Aphthous Stomatitis and the Role of Immunologic Aspects: Literature Review

“…Moreover, in both, RAS and Behçet's syndrome, the risk of the disease development was higher in monozygotic twins than in dizygotic ones (Kobayashi et al 2005; Yilmaz and Cimen 2010). The genetic risk factors that modify the individual susceptibility to RAS include various DNA polymorphisms distributed in the human genome, especially those related with the alterations in the metabolism of interleukins (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12), interferon (IFN)-γ and tumor necrosis factor (TNF)-α (Akman et al 2006, 2008; Bazrafshani et al 2002, 2003; Buño et al 1998; Guimarães et al 2006, 2007; Hall et al 2000; Kalkan et al 2013; Pekiner et al 2012). The role of DNA polymorphisms in serotonin transporter gene, endothelial nitric oxide synthase gene and cell adhesion molecule genes has also been considered (Alkhateeb et al 2013; Gallo et al 2012; Karasneh et al 2005, 2009; Kim et al 2003; Oksel et al 2006; Salvarani et al 2002; Victoria et al 2005; Wang and Wang 2000).…”

Effectiveness and tuberculosis-related safety profile of interleukin-1 blocking agents in the management of Behçet's disease

“…Notably, IL-1 has been found to be increased in the serum [11] and synovial fluid [12] of patients with BD, and furthermore the time of disease onset has been correlated with IL-1 gene specific single nucleotide polymorphisms [13,14]. In addition, monocytes of patients with BD display an increased expression of the purinergic P2 × 7 receptor, a nucleotidegated ion channel, chiefly involved in the inflammatory response triggered by the release of adenosine triphosphate from damaged cells, which in turn promote the inflammasome-driven IL-1β secretion, suggesting the role of innate immunity in BD [15].…”