Common MEFV gene mutations in Turkish patients with Behcet's disease

Is colchicine more effective to prevent periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis episodes in Mediterranean fever gene variants?

“…The clinical picture of the attacks in the MEFV gene variant patients was more compatible with PFAPA than FMF. In the literature, the clinical symptoms in patients with MEFV gene variants were exacerbated in periodic fever syndrome, and in autoimmune diseases such as Behcet's disease and rheumatoid arthritis . Although no association was detected between the severity of symptoms and the presence of MEFV gene mutations in the present study, colchicine prophylaxis was more effective in reducing the frequency of episodes in PFAPA patients with MEFV gene variant.…”

Clinical significance of NCOA5 gene rs2903908 polymorphism in Behçet’s disease

“…Talaat et al (2014[27]) showed that BD patients with active disease had significantly higher levels of IL-6 compared to patients in remission. In addition, many other genes indicated an association with BD (Chen et al, 2012[8]; Yazici et al, 2012[31]; Hou et al, 2013[14]; Kirino et al, 2013[18]; Tasliyurt et al, 2013[28]; Tizaoui et al, 2014[29]; Xiang et al, 2014[30]). However, none of these genes are fully linked to BD.…”

Infection and Behçet Disease

“…6 Although some advances have been made regarding genetic susceptibility and immunology, 7 we still know little about the role of infection in the pathogenesis of this disease. One interesting fact is the association between BD and Mediterranean fever gene mutations, which seem to be increased in patients with BD.…”