Clinical significance of NCOA5 gene rs2903908 polymorphism in Behçet’s disease

Rüstemoğlu, Aydın; İnal, Esra Erkol; Inanir, Ahmet; Ekinci, Duygu; Gül, Ülker; Yığıt, Serbülent; Ateş, Ömer; Karakuş, Nevin

doi:10.17179/excli2017-189

Cited by 7 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a previous study, we have expressed a possible relationship between NCOA5 gene rs2903908 polymorphism and Behçet's Disease. 19 In the present study, we detected signi cant differences between MS patients and healthy controls for NCOA5 gene rs2903908 polymorphism, both in terms of general genotype distribution (p = 0.004, data not shown) and CC genotype (p = 0.0002; OR, 95%CI = 4.16, 1.91-9.05). We also found that there was a signi cant difference between MS patients and controls in terms of allele distribution and that the C allele was high in the patient group (p = 0.003; OR.95%CI = 1.67, 1.20-2.33).…”

Section: Notably International Multiple Sclerosis Genetics Consortium...mentioning

confidence: 44%

“…However, the presence of studies with different results in terms of rs2903908 polymorphism in other autoimmune diseases in the literature suggests that NCOA5 may be effective not only through IL-6 but also through other pathways [17,19,38] [35]. The fact that NCOA5 also actively role in E2-mediated upregulation of RORA expression make us to the thought that NCOA5 may also play a role in the pathogenesis of MS via this pathway.…”

Section: Notably International Multiple Sclerosis Genetics Consortium...mentioning

confidence: 99%

“…The nuclear receptor coactivator 5 (NCOA5) gene, also known as Coactivator Independent of AF2 (CIA), is located in the chromosome 20q.12 -q13.12, a 400-kb surrounding region of CD40, a member of the TNFreceptor superfamily, which is also associated with MS [17][18][19]. The NCOA5 gene encodes a coregulator for the orphan nuclear receptor NR1D2 and the alpha and beta estrogen receptors.…”

Section: Introductionmentioning

confidence: 99%

“…Like other nuclear receptor coactivator genes, NCOA5 deeply involves in a distinctive range of autoimmune, in ammatory and neoplastic diseases. Its insu ciency results in elevated expression and increased levels of IL-6 [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Could NCOA5 a novel candidate gene for multiple sclerosis susceptibility?

Rustemoglu,

Arslan,

Atasever

et al. 2023

Mol Biol Rep

Self Cite

View full text Add to dashboard Cite

BackgroundMultiple sclerosis (MS) is an in ammatory immune-mediated demyelinating disease which characterized a challenging and disabling condition. It is known that environmental and genetic factors play a role in directing the disease state. Recent studies have shown that nuclear cofactor genes may play a role in the MS pathogenesis. NCOA5 is a nuclear receptor coactivator independent of AF2 that modulate ERamediated transcription. NCOA5 gene is also involved in the pathogenesis of various diseases such as psoriasis, Behçet's disease and cancer. Methods and ResultsWe were investigated the relationship between the NCOA5 gene rs2903908 polymorphism and MS disease on 157 unrelated MS patients and 160 healthy controls by RT-PCR. The frequency of CC, CT, and TT genotypes was 19.87%, 37.82%, and 42.31% for the MS group while 5.63%, 43.75%, and 50.62% control group, respectively. In the obtained results, CC genotype and C allele were found to be signi cantly higher in the patient group (p = 0.0002 and 0.003, respectively). In particular, the fact that the CC genotype was found to be signi cantly higher in the patient group compared to the control group (p = 0.0002) and that it had a statistically signi cantly higher OR value (OR,95%CI = 4.16, suggests that the C allele may recessively predispose to the MS disease for this polymorphism. ConclusionsThese results suggest for the rst time in the literature that, the NCOA5 gene may have an effect on the occurrence MS disease through different molecular pathways which discussed in the manuscript.

show abstract

Section: Notably International Multiple Sclerosis Genetics Consortium...mentioning

confidence: 44%