Relationship Between Patient Age and Superficial Transitional Cell Carcinoma Characteristics

Shi, Bibo; Zhang, Ke‐Qin; Zhang, Jing; Chen, Jun; Zhang, Nianzhao; Zhang, Xu

doi:10.1016/j.urology.2008.01.062

Cited by 36 publications

(32 citation statements)

References 22 publications

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“…It is reported that the tumor is more differentiated and less aggressive in bladder tumor patients younger than 40 years of age (28,29). In addition, other studies reported decreased recurrence and progression rates in younger patients as well (28,29,30,31,32). As opposed to this, there are also other studies that showed no significant difference between age (33,34,35).…”

Section: Discussionmentioning

confidence: 94%

The Effect of Sex and Age Differences on Pathology Results in Primary Bladder Cancer Patients

Türk¹,

Ün²,

Ergani³

2017

uob

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Objective: Bladder cancer is more frequently seen in males, whereas prognosis is usually worse in female patients. Although many factors affect the prognosis of urothelial carcinoma of bladder have been proposed, the effect of female gender on the prognosis of bladder urothelial carcinoma is controversial. Several factors have been suggested regarding the effect of gender difference on the prognosis of bladder urothelial carcinoma. Materials and Methods: A retrospective study of 589 patients who underwent transurethral resection for the first time between January 2011 and January 2017 with preliminary diagnosis of bladder cancer was performed. Age, sex, tumor stage, histological subtype and tumor grade were evaluated in the study. Results: No significant difference was found between the sexes in terms of tumor stage (p=0.663). The rate of high-grade tumors was 48.6% (n=235) in males and 63% (n=41) in females and statistically significantly higher in females than males (p<0.041). As the age progressed, it was found that tumor stage and extend increased (p<0.0001). Tumor grade and histological subtype were not statistically significant in terms of age groups. Conclusion:In this study, newly diagnosed bladder tumor patients evaluated and revealed more in male gender. Furthermore, when evaluated in terms of age groups, it was shown that the stage and degree of the tumor increased as the age increased.

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Section: Discussionmentioning

confidence: 94%

The Effect of Sex and Age Differences on Pathology Results in Primary Bladder Cancer Patients

Türk¹,

Ün²,

Ergani³

2017

uob

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show abstract

“…10,11 Males have a 2.5-to 4-times higher risk of bladder cancer compared with females. [12][13][14][15] Shi and colleagues reported that even though this cancer type is more frequent in men, females become also more susceptible due to hormonal changes with advancing age.…”

Section: Discussionmentioning

confidence: 99%

“…[12][13][14][15] Shi and colleagues reported that even though this cancer type is more frequent in men, females become also more susceptible due to hormonal changes with advancing age. 11 In studying the incidence rates of UBC, Poletajew and colleagues found the male-female ratio of patients under 41 was 4:5, and a rate of 3:1 was seen in patients under 50. 16 Likewise, our study showed that the disease was more prominent in males (91.2%).…”

Section: Discussionmentioning

confidence: 99%

Urothelial bladder cancer in young adults: Diagnosis, treatment and clinical behaviour

Günlüsoy

Ceylan

Değirmenci

et al. 2015

CUAJ

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Introduction: The aim of the study is to reveal pathologic characteristics and clinical behaviour of patients 40 years old or younger diagnosed with and treated for urothelial bladder carcinoma. Methods: We retrospectively analyzed the clinical and pathologic data of 91 patients, initially diagnosed and treated at our institution from May 1996 to December 2014. Cancer recurrence was defined as new occurrence of bladder cancer at the same or different sites of the bladder. Cancer progression was defined as an increase in stage or grade in any of the recurrences. Results: The mean age was 33.8 (range: 17-40) years. The pathological examination after transurethral resection revealed 83 (91.2%) patients with non-muscle invasive urothelial bladder cancer, and 8 (8.8%) patients with muscle invasive urothelial bladder cancer. According to the distribution of grade, there were 75, 4 and 12 patients with grade 1, grade 2 and grade 3 diseases, respectively. Initial cancer staging was: pTa with 40 patients (43.9%), pT1 with 43 patients (47.2%), pT2 with 7 patients (7.6%), and pT3 with 1 patient (1.2%). While 17 (18.6%) patients recurred in the followup, 10 (10.9%) patients had progression. There were no differences in recurrence and progression rates in the Ta and T1 stages between groups (p = 0.233, p = 0.511, respectively). Conclusion:The risk of progression increased as the number of relapses increased. The clinical behaviour of high-stage and highgrade disease in younger patients is similar to the older group.

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“…Several recent studies have had findings compatible with our observations. Shi et al 11 also showed that elderly patients are more likely to present with poorly differentiated bladder cancer and that the recurrence-free survival rate decreased with increasing age. However, no difference was found in T category distribution or progression-free survival among the age groups in their study.…”

Section: Commentmentioning

confidence: 97%

“…[3][4][5][6] Other studies have demonstrated that younger patients tend to have lower disease recurrence and progression rates, as well as better survival, compared with older patients. [7][8][9][10][11][12] It is also unclear whether a better prognosis in younger patients is a result of a lower stage and grade at presentation, or whether it is a result of the indolent nature of the tumors in younger patients.…”

mentioning

confidence: 99%

Differences in Tumor Characteristics and Prognosis in Newly Diagnosed Ta, T1 Urothelial Carcinoma of Bladder According to Patient Age

Cho

Hwang

Kim

et al. 2009

Urology

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Relationship Between Patient Age and Superficial Transitional Cell Carcinoma Characteristics

Cited by 36 publications

References 22 publications

The Effect of Sex and Age Differences on Pathology Results in Primary Bladder Cancer Patients

The Effect of Sex and Age Differences on Pathology Results in Primary Bladder Cancer Patients

Urothelial bladder cancer in young adults: Diagnosis, treatment and clinical behaviour

Differences in Tumor Characteristics and Prognosis in Newly Diagnosed Ta, T1 Urothelial Carcinoma of Bladder According to Patient Age

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