Relationship between Oversulfation and Conformation of Low and High Molecular Weight Fucoidans and Evaluation of Their in Vitro Anticancer Activity

Cho, Myoung Lae; Lee, Boo-Yong; You, Sung Hyun

doi:10.3390/molecules16010291

Cited by 134 publications

(78 citation statements)

References 14 publications

(17 reference statements)

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“…Several reports have demonstrated that the sulfate content of fucoidan is important for its anticancer (30) and antiviral (31) activities. Sulfated fucans were responsible for the antiviral activity of certain fractions isolated from a water extract of brown seaweed (31).…”

Section: Discussionmentioning

confidence: 99%

A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria

Kawashima

Murakami²,

Nishimura³

et al. 2011

Int J Mol Med

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Abstract. Fucoidan, a sulfated polysaccharide contained in brown algae, has a variety of immunomodulatory effects, including antitumor and antiviral effects. On the other hand, lactic acid bacteria (LAB) also have immunomodulatory effects such as anti-allergic effects. In this study, we demonstrated that fucoidan enhances the probiotic effects of LAB on immune functions. By using Peyer's patch cells and spleen cells in vitro, fucoidan amplified interferon (IFN)-γ production in response to a strain of LAB, Tetragenococcus halophilus KK221, and this activity was abolished by desulfation of fucoidan. Moreover, this IFN-γ response was abolished by interleukin (IL)-12 neutralization. These results indicate that fucoidan enhanced IL-12 production in response to KK221, resulting in promoting IFN-γ production. In an in vivo study, Th1/Th2 immunobalance was most improved by oral administration of both fucoidan and KK221 to ovalbumin-immunized mice. These findings suggest that fucoidan can enhance a variety of beneficial effects of LAB on immune functions.

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Section: Discussionmentioning

confidence: 99%

A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria

Kawashima

Murakami²,

Nishimura³

et al. 2011

Int J Mol Med

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“…Previously, the level and position of sulphation in fucoidan structure was considered to be an important factor that determines the bioactivity of fucoidan [86]. Cho et al [20] studied the anti-cancer effects of 5-30 kDa and >30 kDa fractions of fucoidan from U. pinnatifida against the human stomach cancer cell line AGS and found that over-sulphation significantly enhanced the inhibition of cell growth for both molecular weight fractions. In this study, fucoidan from F. vesiculosus had the highest sulphation degree of nearly 34%, followed by MMW, HMW, crude extract and then LMW fractions of from S. filipendula.…”

Section: Hmw Fraction Is Responsible For Cytotoxicity Of Crude Fucoidmentioning

confidence: 99%

Fucoidan Inhibition of Osteosarcoma Cells is Species and Molecular Weight Dependent

et al. 2020

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Fucoidan is a brown algae-derived polysaccharide having several biomedical applications. This study simultaneously compares the anti-cancer activities of crude fucoidans from Fucus vesiculosus and Sargassum filipendula, and effects of low (LMW, 10–50 kDa), medium (MMW, 50–100 kDa) and high (HMW, >100 kDa) molecular weight fractions of S. filipendula fucoidan against osteosarcoma cells. Glucose, fucose and acid levels were lower and sulphation was higher in F. vesiculosus crude fucoidan compared to S. filipendula crude fucoidan. MMW had the highest levels of sugars, acids and sulphation among molecular weight fractions. There was a dose-dependent drop in focal adhesion formation and proliferation of cells for all fucoidan-types, but F. vesiculosus fucoidan and HMW had the strongest effects. G1-phase arrest was induced by F. vesiculosus fucoidan, MMW and HMW, however F. vesiculosus fucoidan treatment also caused accumulation in the sub-G1-phase. Mitochondrial damage occurred for all fucoidan-types, however F. vesiculosus fucoidan led to mitochondrial fragmentation. Annexin V/PI, TUNEL and cytochrome c staining confirmed stress-induced apoptosis-like cell death for F. vesiculosus fucoidan and features of stress-induced necrosis-like cell death for S. filipendula fucoidans. There was also variation in penetrability of different fucoidans inside the cell. These differences in anti-cancer activity of fucoidans are applicable for osteosarcoma treatment.

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“…Since the identification of fucoidan, it has been broadly studied for its numerous biological [6][7][8][9][10][11][12] and toxicological properties [13][14][15]. The biological activity of fucoidan has been reported to be closely related to molecular weight [16,17]. A few report showed seaweed extracts having a potential anti-diabetes activity [18].…”

Section: Introductionmentioning

confidence: 99%

Fucoidan regulate blood glucose homeostasis in C57BL/KSJ m+/+db and C57BL/KSJ db/db mice

2012

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Relationship between Oversulfation and Conformation of Low and High Molecular Weight Fucoidans and Evaluation of Their in Vitro Anticancer Activity

Cited by 134 publications

References 14 publications

A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria

A sulfated polysaccharide, fucoidan, enhances the immunomodulatory effects of lactic acid bacteria

Fucoidan Inhibition of Osteosarcoma Cells is Species and Molecular Weight Dependent

Fucoidan regulate blood glucose homeostasis in C57BL/KSJ m+/+db and C57BL/KSJ db/db mice

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