Relationship Between Olfactory Tests and Prognosis of Olfactory Disturbances

Zusho, Hiroyuki; Fukushima, Yoshiko; Oyaizu, Seiko; Oka, Tsuguo; Kuroishi, Toshihiro; Kazama, Reiko; Fujii, Sojiro; Asaka, Hideyo

doi:10.3950/jibiinkoka.83.519

Cited by 2 publications

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“…The report on the occurrence of smell sensation following intravenous neosalvarsan injection by Forchheimer (1916) was the first related to the effects on olfaction of intravenous drug injection, and Ueda (1957) reported the IVO test using PST in 1957. Since then, the IVO test has been widely used in Japan, and olfactory disturbance undetectable with the IVO test was reported to be associated with poor clinical outcome (Zusho et al, 1980). The latent and duration times in the IVO test have been believed not always to be correlated with clinical outcome (Zusho et al, 1980), but this lack of correlation may be the result of inconsistency of olfactory stimuli in the original IVO test.…”

Section: Discussionmentioning

confidence: 99%

“…Since then, the IVO test has been widely used in Japan, and olfactory disturbance undetectable with the IVO test was reported to be associated with poor clinical outcome (Zusho et al, 1980). The latent and duration times in the IVO test have been believed not always to be correlated with clinical outcome (Zusho et al, 1980), but this lack of correlation may be the result of inconsistency of olfactory stimuli in the original IVO test. Kazama and Zusho (1981) reported amounts of PST metabolites in expired air during the IVO test as determined by gas chromatography, and their results have been accepted as standard values.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Smell Intensity Monitoring Using Metal Oxide Semiconductor Odor Sensors during Intravenous Olfaction Test

Nakashima¹,

Kidera²,

Miyazaki³

et al. 2005

Chemical Senses

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The intravenous olfaction test using prosultiamine (PST) solution is simple to perform and has been used clinically in Japan. We monitored intranasal intensity of smell continuously in real time under various conditions of administration using metal oxide semiconductor odor sensors and established an optimal PST injection procedure. In this study, we found that 1) although there was fluctuation in the pattern of intensity of increase in smell in the PST original solution test, the pattern of increase in intranasal smell intensity could be stabilized by prolonging the injection time to 40 s and 2) dilution of PST with physiological saline was effective in preventing angialgia during intravenous injection. It appears that PST administration is best performed by adding 10 ml of saline to 10 mg (2 ml) of PST and injecting the resulting 12-ml solution (6x dilution) and that the best respiratory cycle for testing is once in every 2 s.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%