Olfactory dysfunction in patients with head trauma

Fujii, Megumi; Fukazawa, Keijiro; Takayasu, Sadamu; Sakagami, Masafumi

doi:10.1016/s0385-8146(01)00118-3

Cited by 56 publications

(46 citation statements)

References 16 publications

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“…In the short-term vasoconstrictor decongestant use can help to mitigate the effects of mucosal edema, as can simple nasal saline rinses. Intranasal saline rinses can also provide long-term benefit as can the use of nasal corticosteroid sprays commonly used in the management of nasal allergy or sinusitis [65,66]. When this fails, or in cases of obvious structural derangement of nasoseptal bone or cartilage, surgical intervention may be necessary to restore proper airflow to the olfactory epithelium.…”

Section: Managementmentioning

confidence: 99%

Posttraumatic olfactory dysfunction

Coelho

Costanzo

2016

Auris Nasus Larynx

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Section: Managementmentioning

confidence: 99%

Posttraumatic olfactory dysfunction

Coelho

Costanzo

2016

Auris Nasus Larynx

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“…This olfactometer includes five odorants: (A) b-phenyl ethyl alcohol, (B) methyl cyclopentenolone (cyclotene), (C) isovaleric acid (D) c-undecalactone, and (E) scatole, and each odorant is evaluated at eight levels (-2 to 5), except (B), which is evaluated at 7 (-2 to 4) [15]. Detection threshold is defined as the lowest concentration that subjects can reliably detect, while the recognition threshold is the lowest concentration that subjects can discern.…”

Section: Olfactory Evaluationmentioning

confidence: 99%

Olfactory dysfunction in neuromyelitis optica spectrum disorders

Zhang

Zhao

et al. 2015

J Neurol

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Few data were available for the understanding of olfactory function in neuromyelitis optica spectrum disorders (NMOSDs). The aims of our study were to investigate the incidence of olfactory dysfunction and characterize olfactory structures, using MRI, in patients with NMOSDs. Olfactory function was evaluated by olfactometer in 49 patients with NMOSDs and 26 matched healthy controls. MRI parameters such as olfactory bulb (OB) and the olfactory-related gray matter volume changes were assessed. The frequency of olfactory dysfunction was 53% in patients with NMOSDs. Olfactory detection thresholds were positively correlated with serum aquaporin-4 antibodies (fluorescent units) tested by fluorescent immunoprecipitation assay (FIPA) in NMOSDs (p = 0.009). Patients with olfactory dysfunction had smaller OB volume than did patients without olfactory dysfunction or controls (p < 0.01). Both detection and recognition thresholds for olfaction were negatively correlated with OB volume (p = 0.018, p < 0.01). The significant gray matter volume reduction in NMOSDs was found in the bilateral piriform cortex, orbitofrontal cortex, and parahippocampal gyri (FDR correction, p < 0.05, cluster size >200 voxels). Our data suggested that olfactory function deficits are prevalent in patients with NMOSDs. Reduced OB and olfactory-related cortex volume may be responsible for the olfactory dysfunction.

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“…Summer [7] reported that occipital impact produced significantly more olfactory dysfunctions than frontal or temporal impacts. In a study by Fujii et al [8], 45.8% of the patients with olfactory impairments had frontal impact and 37.5% had occipital impact during the accident. Similar proportions were found by Doty et al [9].…”

Section: Introductionmentioning

confidence: 95%