Relationship between ocular pulse amplitude and systemic blood pressure measurements

Grieshaber, Matthias C.; Katamay, Robert; Gugleta, Konstantin; Kochkorov, Asan; Flammer, Josef; Orgül, Selim

doi:10.1111/j.1755-3768.2008.01217.x

Cited by 51 publications

(54 citation statements)

References 36 publications

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“…This is illustrated by the observation that a defined blood volume change in the choroid results in a smaller relative change in pressure in myopic eyes than in shorter emmetropic eyes [5,56]. In addition, the reduced scleral rigidity in myopic eyes results in less resistance to enlargement of the pulsatile volume [59].…”

Section: Opa and Glaucomamentioning

confidence: 99%

“…By recording the pulsatile component of the ocular blood flow over a period of time, the OPA may provide an indirect measurement of the uveal blood volume changes during the cardiac cycle, as the choroid represents most of the ocular blood volume and receives 80-90% of the local flow [3]. Accordingly, OPA has been proposed as an index of ocular hemodynamics [4,5]. Furthermore, it has been suggested as a surrogate outcome for extraocular hemodynamics, the rationale being that anything that interferes with ocular perfusion will likely affect OPA measurements.…”

Section: Introductionmentioning

confidence: 99%

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Review on Dynamic Contour Tonometry and Ocular Pulse Amplitude

et al. 2015

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Intraocular pressure (IOP) measurement is the cornerstone of the management of glaucoma patients. The gold standard for assessing IOP is Goldmann applanation tonometry (GAT). Recently, the dynamic contour tonometer (DCT) has become available. While both devices provide reliable IOP measurements, the results are not interchangeable. DCT has the advantage of measuring an additional parameter: ocular pulse amplitude (OPA). OPA is defined as the difference between systolic and diastolic IOP and represents the pulsatile wave front produced by the varying amount of blood in the eye during the cardiac cycle. It has been shown to vary with ocular structural parameters, such as axial length, corneal thickness, and ocular rigidity, as well as with systemic variables like heart rate, blood pressure, and left ventricular ejection fraction. Although the existence of some of these associations is still controversial, the clinical relevance of OPA has been consistently suggested, especially in glaucoma. Further research on this intriguing parameter could not only provide insight into glaucoma pathophysiology but also help integrate this variable into clinical practice.

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Section: Opa and Glaucomamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Review on Dynamic Contour Tonometry and Ocular Pulse Amplitude

et al. 2015

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“…19 The relationship between ocular pulse amplitude (OPA) and hemodynamic changes was also investigated in some studies. 20,21 OPA can be measured with dynamic contour tonometer, which is a nonapplation tonometer. It measures IOP levels and OPA without influence of anterior segment structures by a contour matched pressure sensing tip.…”

Section: Introductionmentioning

confidence: 99%

Ocular pulse amplitude and retrobulbar blood flow change in dipper and non-dipper individuals

Karadağ

Keskin

Köktener

et al. 2011

Eye

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Purpose To evaluate ocular pulse amplitude (OPA), IOP values, and hemodynamic changes in the ophthalmic artery, central retinal artery, and short posterior ciliary artery in dipper and non-dipper patients. Methods A total of 59 right eye measurements of healthy subjects with normotensive were included to the study. Ambulatory blood pressure (BP) monitoring measurement (ABPM), Doppler imaging, and OPA measurements were performed in the same day. The patients in which systolic BP decreased during the nocturnal time by 10% of the diurnal BP or more were called dippers. A patient whose nocturnal systolic BP fell by o10% or even rose was defined as non-dipper.Color Doppler imaging was used for blood flow velocity assessment of ophthalmic, central retinal, and posterior ciliary arteries. For each artery, peak systolic and end-diastolic velocities (PSV and EDV, respectively), resistive index (RI), and pulsalite index (PI) were automatically calculated by the machine. Mean IOP and OPA values were calculated after three consecutive measurements. Results The mean OPA in non-dipper patients was significantly lower compared with that of dipper patients (P ¼ 0.011). There was no significant difference in IOP levels between groups. There was no significant difference in the PSV, EDV, RI, and PI in the ophthalmic, posterior ciliary, and central retinal arteries between the groups. Conclusion Our study demonstrated that OPA level in non-dippers is lower than dippers. This may give additional information about the effect of BP changes on OPA values.

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“…In an initial study, blood pressure was found to be correlated with OPA (Pourjavan, 2007). Subsequent studies could not confirm an impact of blood pressure on OPA (Grieshaber MC., 2009) and found no correlation with the blood pressure amplitude itself (Choi J., 2010). However, there have been case reports of OPA being increased in patients with aortic insufficiency (McKee HD., 2004) and decreased in patients with carotid stenosis (Perkins, 1985).…”

Section: Altered Blood Flow As a Risk Factor For Glaucoma (Progression)mentioning

confidence: 99%

“…Further reports about increases in OPA after correcting upstream arterial stenosis (Kaufmann C., 2002) give support to the intuitive notion that blood pressure might yet be important. Of note, the studies that have ruled out a relationship between blood pressure and OPA were either performed in young healthy volunteers (Grieshaber MC., 2009) or in glaucoma patients with normal arterial blood pressure (Choi J., 2010).…”

Section: Altered Blood Flow As a Risk Factor For Glaucoma (Progression)mentioning

confidence: 99%