2021
DOI: 10.1016/j.chest.2021.01.081
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Relationship Between Obesity and Ventilator-Associated Pneumonia

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Cited by 16 publications
(12 citation statements)
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“…The investigators observed that the incidence of ventilator-associated pneumonia was comparable between obese and nonobese patients. 22 Consistent with previous population studies describing an obesity paradox, [23][24][25][26] children with obesity and neurologic disorders in our study cohort were less likely to develop postoperative pneumonia than healthy weight or overweight children with neurologic disorders. One study examining the obesity paradox in community-acquired pneumonia in adult patients found that obesity and overweight were associated with a reduction of 5.7% and 8.6%, respectively, in 30-day mortality, suggesting a lower risk of obese than for overweight subjects.…”
Section: Discussionsupporting
confidence: 92%
“…The investigators observed that the incidence of ventilator-associated pneumonia was comparable between obese and nonobese patients. 22 Consistent with previous population studies describing an obesity paradox, [23][24][25][26] children with obesity and neurologic disorders in our study cohort were less likely to develop postoperative pneumonia than healthy weight or overweight children with neurologic disorders. One study examining the obesity paradox in community-acquired pneumonia in adult patients found that obesity and overweight were associated with a reduction of 5.7% and 8.6%, respectively, in 30-day mortality, suggesting a lower risk of obese than for overweight subjects.…”
Section: Discussionsupporting
confidence: 92%
“…On the other hand, other studies, while confirming a higher rate of invasive ventilation and ICU admission among obese patients, found a similar rate of death in obese and lean patients [6,7,26]. The lack of negative influence of obesity on mortality or even the protective influence, known as the obesity paradox, has been already described in community-acquired, ventilator-associated pneumonia and ARDS with variable followup [8,9,38]. Consistent with these findings, we did not find a difference in mortality between obese patients and their lean counterparts or in patients with or without MS.…”
Section: Discussionmentioning
confidence: 79%
“…In the course of the ongoing pandemic, robust evidence has identified obesity as a common risk factor for negative outcomes in infections caused by SARS-CoV-2 (COVID-19) [4]. However, as regards mortality, the relationship with obesity in COVID-19 is still unclear, since some studies demonstrated a negative [5] or neutral impact [6,7], near to the so-called "obesity paradox", which is the inverse correlation between body mass index (BMI) and mortality, already described in infectious [8,9] and non-infectious diseases [10,11]. These conflicting results might be explained by the questionable use of BMI, since it does not distinguish between visceral and subcutaneous fat tissue.…”
Section: Introductionmentioning
confidence: 99%
“…Although obesity increases the risk of mortality in the general population, it has been associated with improved survival among critically ill patients [ 10 12 ]. Similarly, a meta-analysis including 6,268 patients with ARDS revealed that obese patients with ARDS have lower mortality than those with a normal BMI [ 7 , 8 , 26 ]. This counterintuitive phenomenon is referred to as the “obesity paradox in ARDS”, and the underlying mechanism for this intriguing phenomenon has yet to be elucidated.…”
Section: Discussionmentioning
confidence: 99%