2022
DOI: 10.1016/j.clnesp.2022.07.003
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The impact of body composition on mortality of COVID-19 hospitalized patients: A prospective study on abdominal fat, obesity paradox and sarcopenia

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Cited by 15 publications
(11 citation statements)
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“…However, our study showed a significant increase in mortality for patients with BMI ≥ 40, both compared to other BMI categories and specifically compared to normal BMI of 20–29.9, likely owing to the increased power of our investigation. Our results were similar to a study conducted in Italy by Graziano et al [ 14 ], who found that an increased waist circumference and abdominal adiposity were associated with an increased need for IMV. We also observed an increase of 37% for odds of requiring IMV, 36% for odds of mortality associated with IMV, and 38% for odds of developing septic shock among obese patients.…”
Section: Discussionsupporting
confidence: 92%
“…However, our study showed a significant increase in mortality for patients with BMI ≥ 40, both compared to other BMI categories and specifically compared to normal BMI of 20–29.9, likely owing to the increased power of our investigation. Our results were similar to a study conducted in Italy by Graziano et al [ 14 ], who found that an increased waist circumference and abdominal adiposity were associated with an increased need for IMV. We also observed an increase of 37% for odds of requiring IMV, 36% for odds of mortality associated with IMV, and 38% for odds of developing septic shock among obese patients.…”
Section: Discussionsupporting
confidence: 92%
“…The regions with the highest share of body fat were the abdominal region and the suprailiac region. In this sense, the study by Graziano et al [22] indicates that although obesity and metabolic syndrome (MS) are not associated with greater intensive oxygen support, this association is significant in patients with excessive abdominal adiposity [22]. According to recent evidence, adequate control of metabolic disorders is important to reduce the risk of severe COVID-19 [23].…”
Section: Discussionmentioning
confidence: 99%
“…However, in a prospective study on the impact of obesity, metabolic syndrome and body composition on clinical outcomes and mortality of patients with COVID-19, an abdominal adipose tissue paradox was found, since waist circumference and visceral tissue metabolically active (VTM) were risk factors for more intensive oxygen support, but not for mortality [22]. Compared to the non-severe COVID-19 group, VTM accumulation levels were significantly higher in COVID-19 patients with a severe condition.…”
Section: Discussionmentioning
confidence: 99%
“…Of the patients with COVID-19induced pneumonia, abdominal obesity, measured by waist circumference (WC) and waist-to-height ratio, positively correlated more closely with high chest X-ray (CXR) severity score than BMI and is an independent factor associated with high CXR severity scores [166]. Increased visceral adipose tissue is positively associated with severe forms of COVID-19 pneumonia [167,168], higher need for ventilatory support [169], and intensive care [170][171][172], while subcutaneous adipose tissue is not significantly correlated with the severity of COVID-19 pneumonia [167,168]. BMI is negatively related to the risk of lung cancer, while WC and waist-to-hip ratio (WtHR) are positively and linearly associated with the risk [173].…”
Section: Body Shapementioning
confidence: 99%