Relationship between obesity and iron deficiency anemia: is there a role of hepcidin?

Sal, Ertan; Yenicesu, İdil; Çelik, Nurullah; Paşaoğlu, Hatîce; Çelik, Bülent; Paşaoğlu, Özge Tuğçe; Kaya, Zühre; Koçak, Ülker; Çamurdan, Orhun; Bideci, Aysun; Cinaz, Peyami

doi:10.1080/10245332.2018.1423671

Cited by 53 publications

(62 citation statements)

References 32 publications

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“…In this study similar concentrations of ferritin and iron were found in obese and non-obese groups. This is similar to the results obtained by Aeberli et al [ 14 ], Sanad et al [ 16 ] and Sal et al [ 19 ]. Ferritin is considered an indicator for determining iron deficiency, but serum ferritin levels had weak correlations with serum iron levels and transferrin saturation [ 40 ].…”

Section: Discussionsupporting

confidence: 93%

“…One of the proposed causes of hypoferritinemia in obesity is deficient iron intake from an iron poor diet [ 13 ], but some studies suggest this is not the cause [ 14 , 15 ]. Several researchers have demonstrated that iron deficiency is associated with the higher circulation of hepcidin in obese subjects, including children and adolescents [ 16 , 17 , 18 , 19 ]. Other studies showed lower values of hepcidin-25 and hyperferritinemia in overweight and obese children compared with their normal-weight counterparts [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake

Gajewska¹,

Ambroszkiewicz²,

Klemarczyk³

et al. 2018

IJERPH

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Iron metabolism may be disrupted in obesity, therefore, the present study assessed the iron status, especially ferroportin and hepcidin concentrations, as well as associations between the ferroportin-hepcidin axis and other iron markers in prepubertal obese children. The following were determined: serum ferroportin, hepcidin, ferritin, soluble transferrin receptor (sTfR), iron concentrations and values of hematological parameters as well as the daily dietary intake in 40 obese and 40 normal-weight children. The ferroportin/hepcidin and ferritin/hepcidin ratios were almost two-fold lower in obese children (p = 0.001; p = 0.026, respectively). Similar iron concentrations (13.2 vs. 15.2 µmol/L, p = 0.324), the sTfR/ferritin index (0.033 vs. 0.041, p = 0.384) and values of hematological parameters were found in obese and control groups, respectively. Iron daily intake in the obese children examined was consistent with recommendations. In this group, the ferroportin/hepcidin ratio positively correlated with energy intake (p = 0.012), dietary iron (p = 0.003) and vitamin B12 (p = 0.024). In the multivariate regression model an association between the ferroportin/hepcidin ratio and the sTfR/ferritin index in obese children (β = 0.399, p = 0.017) was found. These associations did not exist in the controls. The results obtained suggest that in obese children with sufficient iron intake, the altered ferroportin-hepcidin axis may occur without signs of iron deficiency or iron deficiency anemia. The role of other micronutrients, besides dietary iron, may also be considered in the iron status of these children.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake

Gajewska¹,

Ambroszkiewicz²,

Klemarczyk³

et al. 2018

IJERPH

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“…Because transferrin is an acute-phase protein, it is characterised by severe reductions in the early period after major trauma. [19] In the literature, to our knowledge, no studies related to the relationship between physiotherapy and transferrin has been found. Pouramir et al [20] reported that long-term exercise may drain iron deposits and cause…”

Section: Discussionmentioning

confidence: 97%

The Effect of Early Physiotherapy on Biochemical Parameters in Major Burn Patients: A Burn Center’s Experience

Çınar

Bayramlar

Erkılıç³

et al. 2018

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: This study sets out to investigate the effects of early physiotherapy on biochemical parameters in major burn patients. METHODS: Ten women (50%) and 10 men (50%) aged 21-47 years old were included in this study. Participants were divided into two groups: the first group was the treatment group and the second group was the control group. In the treatment group, patients were admitted to the physiotherapy programme from the first day they have been hospitalised, in addition to their routine treatment (e.g. medical, surgery), for four days per week. The physiotherapy programme consisted of parameters, such as early mobilisation and ambulatory training, chest physiotherapy, and both active and passive normal joint movement exercises. The days of treatment were determined as of Tuesday, Wednesday, Thursday and Friday. Patients could not be treated on a Monday because that was surgery day. The control group consisted of patients who could not receive physiotherapy due to various reasons. All patients included in this study were evaluated weekly for six weeks after admission to the hospital. Parameters, such as demographic information, characteristics of burn injury, C-reactive protein, fibronectin, transferrin and prealbumin, were evaluated. RESULTS: When the results obtained in this study were considered, there was a significant difference in favour of the treatment group for all biochemical parameters (p<0.05). From the second week, a significant increase was observed in prealbumin values in the treatment group (p<0.05). A significant increase was observed in fibronectin after the fourth week (p<0.05). CONCLUSION: We believe that early physiotherapy should be included in the treatment in major burns. Early physiotherapy may reduce the effects of hypermetabolic response after major burns. There is a need for multi-centered and broader studies.

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“…Jika metabolisme besi terganggu, maka terjadilah anemia. (Sal et al, 2018;McClung and Karl, 2008 ;Lopez et al, 2011) Timbunan lemak pada hati juga dapat memicu pembentukan peroksida lipid yang pada akhirnya akan mempengaruhi proses metabolisme besi sehingga akan terjadi radikal bebas. Hal ini menyebabkan sintesis Hb tidak dapat berjalan dengan sempurna.…”

Section: A Indeks Massa Tubuhunclassified

Hubungan Indeks Massa Tubuh Dengan Kejadian Anemia Pada Wanita Usia Subur Pranikah

Pasalina

Jurnalis

Ariadi

2019

Jurnal Ilmu Keperawatan dan Kebidanan

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AbstrakWanita Usia Subur (WUS) merupakan kelompok usia dengan prevalensi anemia yang cukup tinggi, di Indonesia mengalami peningkatan dari 19,7%(2007) menjadi 22,4% (2013). Status besi WUS pranikah berdampak pada outcome maternal dan neonatal saat kehamilan. Hubungan Indeks Massa Tubuh (IMT) dan anemia masih kontroversial. Berat badan kurus merupakan indikasi rendahnya asupan mikronutrien yang berhubungan dengan anemia. Pada studi lain, berat badan berlebih/ obesitas meningkatkan resiko anemia karena peningkatan sitokin inflamasi (Interleukin-6) yang menstimulasi peningkatan hepsidin dan penurunan penyerapan besi. Tujuan penelitian ini adalah menganalisis hubungan Indeks Massa Tubuh dengan kejadian anemia pada WUS pranikah. Penelitian ini berjenis analitik observasional dengan metode pendekatan cross sectional dilakukan pada 36 WUS pranikah ( 18 anemia dan 18 tidak anemia) di Kantor Urusan Agama (KUA) Kecamatan Koto Tangah Kota Padang. Pengambilan sampel dilakukan secara consecutive sampling. Pengukuran tinggi badan menggunakan microtoice dan berat badan menggunakan timbangan pegas. Pemeriksaan hemoglobin dengan metode sianmethemoglobin di Laboratorium Biokimia Universitas Andalas. Uji Bivariat dilakukan dengan uji Chi Square.Hasil penelitian menunjukkanWUS dengan IMT berlebih merupakan persentase terbesar (66,7%) yang ditemukan pada kelompok anemia. Tidak terdapat hubungan antara IMT dengan kejadian anemia dengan nilai p 0,7 (p>0,05). Kesimpulan penelitian ini adalah tidak terdapat hubungan antara IMT dengan kejadian anemia. Kata Kunci: Indeks Massa Tubuh, Kejadian Anemia AbstractWomen of Reproductive Age (WRA) are an age group with a fairly high anemia prevalence in Indonesia, increasing from 19.7% (2007) to 22.4% (2013). Iron status of premarital women affects maternal and neonatal outcomes during pregnancy. The relationship between the Body Mass Index (BMI) and anemia is controversial. Underweight indicates of inadequate dietary intake of micronutrients associated with anemia. In other study, overweight/obesity also increase anemia risk because release of proinflammatory cytokines (Interleukin-6) and which stimulates release of hepsidin and decrease iron absorbtion. The purpose of this study was to analyze the relationship between body mass index with the incidence of anemia in premarital WRA. This research was an observational analytic type with a cross sectional approach performed on 36 premarital WRA (18 with anemia and 18 without anemia) in Koto Tangah District, Padang. Sampling was done by consecutive sampling. Body height is measured by microtoice and body weight is measured by manual scale. Hemoglobin was examined with the cyanmethemoglobin method at the Andalas University Biochemistry. Bivariate test was carried out by Chi Square test. The results showed overweight women is the highest percentage (66,7%) in anemia group. There was no relationship between BMI and the incidence of anemia (p > 0.05). The study concluded that there was no relationship between BMI and anemia. Keywords: Body Mass Index, Anemia

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Relationship between obesity and iron deficiency anemia: is there a role of hepcidin?

Abstract: Our study suggests that hepcidin levels do not contribute to the development of iron deficiency anemia in pediatric obese individuals.

Cited by 53 publications

References 32 publications

Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake

Ferroportin-Hepcidin Axis in Prepubertal Obese Children with Sufficient Daily Iron Intake

The Effect of Early Physiotherapy on Biochemical Parameters in Major Burn Patients: A Burn Center’s Experience

Hubungan Indeks Massa Tubuh Dengan Kejadian Anemia Pada Wanita Usia Subur Pranikah

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