Relationship Between Neurocognitive Function and Quality of Life After Whole-Brain Radiotherapy in Patients With Brain Metastasis

Li, Jing; Bentzen, Søren M.; Li, Jialiang; Renschler, Markus F.; Mehta, Minesh P.

doi:10.1016/j.ijrobp.2007.09.059

Cited by 264 publications

(171 citation statements)

References 27 publications

Supporting

Mentioning

154

Contrasting

Unclassified

Order By: Relevance

“…In particular, elderly patients are more likely to suffer a decline in neurocognitive function following radiotherapy [14], which is known to correlate with quality of life [15]. Accordingly, elderly patients may be better served with local therapy alone.…”

Section: Discussionmentioning

confidence: 99%

Fractionated Helical Tomotherapy as an alternative to radiosurgery in patients unwilling to undergo additional radiosurgery for recurrent brain metastases

Sanghera

Lightstone²,

Hyde³

et al. 2010

BJR

View full text Add to dashboard Cite

ABSTRACT. Our clinic routinely treats brain metastases with stereotactic radiosurgery using a 6 megavoltage (MV) linear accelerator, cones, and a surgically attached head frame. Four patients declined repeat radiosurgery for new lesions due to their previous discomfort and a fifth patient could not complete radiosurgery because of uncontrolled nausea. Instead patients were treated with Helical Tomotherapy (HT). This report discusses the spatial dose distribution of HT as measured in a head phantom and the clinical course of these five patients. The planning target volume (PTV) was a 3 mm geometric expansion of the gross tumour volume (GTV). The prescribed dose to the PTV was 27 Gy in five daily fractions with the distribution optimised to deliver 30 Gy to the GTV. Patients were immobilised with a mask and the lesions were targeted by MV computerised tomography, an inherent feature of the system. One patient died six weeks later from systemic disease; the remaining patients survived eight to 16 months. No patient experienced an exacerbation of neurological symptoms following Helical Tomotherapy. These results suggest that fractionated Helical Tomotherapy for brain metastases may be a viable alternative to radiosurgery in patients unable or unwilling to undergo that procedure.

show abstract

Section: Discussionmentioning

confidence: 99%

Fractionated Helical Tomotherapy as an alternative to radiosurgery in patients unwilling to undergo additional radiosurgery for recurrent brain metastases

Sanghera

Lightstone²,

Hyde³

et al. 2010

BJR

View full text Add to dashboard Cite

show abstract

“…As part of a phase III trial, neurocognitive function (NCF) and quality of life (QoL) measurements were acquired serially in 208 patients treated with WBRT. The changes in NCF and QoL were correlated to each other such that a decline in neurocognitive function in terms of executive function and fine motor coordination was associated with deterioration in quality of life [31]. However, it is possible that other factors including progressive extracranial disease can affect NCF and QoL measures.…”

Section: Treatment-related Toxicitiesmentioning

confidence: 98%

Conventional radiation therapy for brain metastases

2012

View full text Add to dashboard Cite

Conventional radiotherapy in the form of whole brain radiation treatment has been a longstanding treatment for brain metastases, and it continues to provide effective palliation as monotherapy and in combination with local and systemic treatments. Advances in systemic therapy have improved survival with metastatic disease, and in those patients with better prognostic factors, more aggressive local therapeutic approaches for brain metastases appear to benefit their survival and intracranial tumor control. Increased treatment intensity and longer survival following treatment of brain metastases have raised concerns about persistent treatmentrelated neurocognitive toxicities and the resulting impact on quality of life. Technological advances in conventional radiotherapy planning and delivery have led to novel approaches that may increase intracranial tumor control while minimizing the treatment-related toxicities of therapy. These innovative approaches include intensitymodulated radiotherapy, new image-guidance techniques, and volumetric modulated arc therapy, which allow for the delivery of whole brain radiotherapy with integrated boost treatment to the visible disease while sparing the hippocampal regions or delivery of hypofractionated radiotherapy to larger metastatic targets that may not be amenable to radiosurgery boost or salvage treatment.

show abstract

“…Contar cartas que se presentan de forma auditiva. Cada carta contiene diferentes palabras (ciudades, países y ríos) y después se presenta un dígito (4,5,6): el sujeto tiene que decidir si el número de letras de la palabra coincide con el dígito que acababan de presentar. 3.…”

Section: Sesión 6: Resumenunclassified

“…Una de las manifestaciones clínicas más frecuentes en estos pacientes son los défi-cits cognitivos, que se asocian a su vez a elevada morbilidad y a una negativa en su calidad de vida (3)(4)(5) , los que convierte a los tumores cerebrales en una de las principales patologías neurológicas con este tipo de sintomatología (6) . Sin embargo, los datos de prevalencia sobre los déficits cognitivos en pacientes con tumores cerebrales son muy dispersos en función de los diferentes estudios, oscilando los porcentajes entre el 12% y el 90%, durante todo el proceso de la enfermedad (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) .…”

Section: Introductionunclassified

Rehabilitación neuropsicológica en pacientes con tumores cerebrales

Cortés¹,

Crespo

2014

Psicooncología

View full text Add to dashboard Cite

ResumenLos déficits cognitivos son uno de los sínto-mas más frecuentes en pacientes con tumores cerebrales, principalmente en atención, memoria y funciones ejecutivas. Estas alteraciones impactan de forma negativa en al calidad de vida de los pacientes y en su reincorporación a su funcionamiento diario. En los últi-mos años se están desarrollando programas de Rehabilitación Neuropsicológica en pacientes adultos con tumores cerebrales, con resultados positivos. Así, los autores recomiendas que las intervenciones incluyan técnicas de psico-educación, estrategias de recuperación de los diferentes procesos atencionales y de ejecutivos (planificación y organización), así como técni-cas compensatorias para la memoria. Los trabajos publicados hasta la fecha muestran mejoría inmediatamente después de la intervención en atención y memoria. Sin embargo, no existen datos del impacto de estos programas de Rehabilitación en el rendimiento de estos pacientes a medio y largo plazo (más de seis meses). Futuros estudios necesitan evaluar la eficacia de este tipo de intervención en pacientes mayores con tumores cerebrales, así como diferenciar los resultados en función del tipo de tumor y de los tratamientos oncológicos aplicados, ya que estas dos características pueden afectar de forma significativa a los datos obtenidos.Palabras clave: tumores cerebrales, pacientes adultos, Rehabilitación Neuropsicológica. The authors recommend that interventions include psychoeducation techniques, recovery strategies of different attentional and executive processes (planning and organization) and compensatory techniques for memory. The studies published to date show improvement immediately after surgery in attention and memory. However, there are not data exist on the impact of these programs on performance rehabilitation of these patients in the medium and long term (over six months). The future studies need to evaluate the effectiveness of this intervention in elderly patients with brain tumors, and the results differ depending on the type of tumor and cancer treatments applied, as these two features can significantly affect the data obtained.

show abstract

Relationship Between Neurocognitive Function and Quality of Life After Whole-Brain Radiotherapy in Patients With Brain Metastasis

Cited by 264 publications

References 27 publications

Fractionated Helical Tomotherapy as an alternative to radiosurgery in patients unwilling to undergo additional radiosurgery for recurrent brain metastases

Fractionated Helical Tomotherapy as an alternative to radiosurgery in patients unwilling to undergo additional radiosurgery for recurrent brain metastases

Conventional radiation therapy for brain metastases

Rehabilitación neuropsicológica en pacientes con tumores cerebrales

Contact Info

Product

Resources

About