Relationship between mold exposure, specific IgE sensitization, and clinical asthma

Vincent, Martin J.; Corazza, Francis; Chasseur, Camille; Bladt, Sandrine; Romano, Márta; Huygen, Kris; Denis, Olivier; Michel, Olivier

doi:10.1016/j.anai.2018.06.016

Cited by 21 publications

(25 citation statements)

References 41 publications

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“…In terms of the fungal species, Aspergillus fumigatus has shown to induce one of the highest sensitizations for moderate/severe asthma [54,78]. In addition, human colonization of the genera Cladosporium, Alternaria, and Penicillium have been associated with severe asthma and their ambient environmental concentration is similarly proportional in various parts of the world [41,45,53,[56][57][58]. For viruses, rhinovirus has been shown to be one of the most common triggers of a viral source for an asthma exacerbation [9, 11•, 15, 63, 79, 80].…”

Section: Resultsmentioning

confidence: 99%

“…Chopra and colleagues showed that asthma patients with skin reactivity to the Aspergillus skin test (AST) had more cases of moderate and severe asthma versus nonreactive AST patients (98.6% vs. 3.2%, p < 0.001) in a cohort of 282 adult asthma patients over a 1-year period. Sensitization to Aspergillus has been found to have a more significant impact on asthma outcomes compared to other species of fungus [41,42]. For instance, Vincent et al [41] demonstrated that adult asthma patients who were sensitized to Penicillium chrysogenum, , p = 0.059) [41].…”

Section: Endotoxinmentioning

confidence: 99%

“…Sensitization to Aspergillus has been found to have a more significant impact on asthma outcomes compared to other species of fungus [41,42]. For instance, Vincent et al [41] demonstrated that adult asthma patients who were sensitized to Penicillium chrysogenum, , p = 0.059) [41]. Masaki and colleagues' study in Japan implicates a different species; their study investigated sensitization to Candida and found that out of 124 adults with asthma, more people had sensitization to Candida than Aspergillus (16 vs. 11%) [6].…”

Section: Endotoxinmentioning

confidence: 99%

“…Fungal exposure also impacts lung function [41]. Asthma patients with sensitization to Aspergillus fumigatus have been found to have higher total serum IgE levels and an increased degree of broncho-obstruction (as measured by FEV 1 /FVC), compared to asthmatic patients without sensitization [41,50]. The impact of fungal exposure on lung function has been evaluated in adults; however, this has not been thoroughly evaluated in infants and young children.…”

Section: Endotoxinmentioning

confidence: 99%

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The Impact of Ambient Environmental Exposures to Microbial Products on Asthma Outcomes from Birth to Childhood

Howard

Orhurhu

Huang

et al. 2019

Curr Allergy Asthma Rep

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Purpose of Review Asthma is a chronic respiratory condition with increasing domestic and worldwide prevalence that burdens individuals and the healthcare system with high costs associated with long-term treatments and acute emergency room (ER) visits. It can be triggered by ambient microbes, including bacteria, viruses, and fungi. In this review, we examine the outcomes of asthma patients in relation to environmental exposures to ambient microbe products, focusing on whether exposure leads to asthma development from birth to childhood and if particular microbes are associated with worsened asthma exacerbations. Recent Findings Bacterial endotoxin is more prominent in homes with pets and may cause cytokine cascades that lead to asthma exacerbation. However, some studies have demonstrated a protective effect with early exposure. Patients with positive Aspergillus skin testing are more prone to moderate-severe or severe-uncontrolled asthma. Fungal sensitization is also associated with earlier onset of asthma and demonstrates a dose-dependent relationship of symptom severity and duration. Among viruses, rhinovirus has the greatest association with decreased lung function, severe asthma, and asthma-related hospital admissions. Distribution of microbial products and associated asthma symptoms depends on the geographical climate. Genetic variations among individuals also mitigate the effects of microbial products on asthma development and symptom severity. Summary Microbial products of bacteria, fungi, and viruses are associated with the development of asthma, more severe asthma symptoms, and worse outcomes. However, some early exposure studies have also demonstrated a protective effect. Bacterial and fungal products are related to decreased lung function and earlier onset of asthma. Viral products are related to asthma-associated hospital admissions; and the climate and patient genetics can also temper or intensify the relationships between microbial products, asthma development, and asthma symptom severity. Further research should focus on the effects of early microbe exposure and its interaction with human immune systems and asthma-related outcomes.

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Section: Resultsmentioning

confidence: 99%

Section: Endotoxinmentioning

confidence: 99%

Section: Endotoxinmentioning

confidence: 99%

Section: Endotoxinmentioning

confidence: 99%

See 2 more Smart Citations

The Impact of Ambient Environmental Exposures to Microbial Products on Asthma Outcomes from Birth to Childhood

Howard

Orhurhu

Huang

et al. 2019

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

show abstract

“…Besides the Aspergillus fumigatus specific IgE level, also the total IgE level is increasing throughout groups – yet, the difference was not significant (see Table 3). Vincent et al [40] described a generally elevated total IgE level for patients sensitized to Aspergillus fumigatus , when compared to patients sensitized to other molds or nonfungal allergens.…”

Section: Discussionmentioning

confidence: 99%

Value of Component Resolved Diagnostics to Aspergillus fumigatus in Patients with Upper Airway Complaints

Volgger

Louza

Gellrich

et al. 2020

Int Arch Allergy Immunol

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Introduction: Sensitization to Aspergillus fumigatus is a risk factor for severe asthma. However, little is known about its presence, appearance, and impact on allergic rhinitis. Herein, we investigated the usefulness of component resolved diagnostics in patients sensitized to Aspergillus fumigatus protein extract. Methods: Seventy-eight patients with suspected allergic rhinitis and elevated IgE levels toward Aspergillus fumigatus protein extract were retrospectively evaluated regarding their total and Aspergillus-specific IgE levels and their skin prick test. Furthermore, they were tested for specific IgE antibodies against Asp f 1, 2, 3, 4, and 6. Results: Skin prick test missed 6 patients (7.7%) with elevated IgE toward Aspergillus fumigatus protein extract. Fifty percent of patients (n = 39) were sensitized to at least one component. Even though monosensitization affected all components, all patients with positivity toward more than one component were sensitized to Asp f 1. There was a statistically significant increase of Aspergillus-specific IgE with increasing number of components affected by sensitization. Many patients were oligo- (34.6%) or polysensitized (51.3%). There was a high prevalence of sinusitis (61.8%). Conclusions: Component resolved diagnostic testing toward the major allergen Asp f 1 was less sensitive than skin prick test and serology to Aspergillus fumigatus protein extract. However, sensitivity of component resolved diagnostics might be underestimated. Diagnostics of the species-specific allergens Asp f 1, 2, and 4 might allow to differentiate between genuine and cross-reactive sensitization. In the clinical routine, skin prick test and serology to crude extract remain the methods of choice.

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Indoor Microbial Exposures and Chronic Lung Disease

Wolf

Lai

2020

Clinics in Chest Medicine

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Relationship between mold exposure, specific IgE sensitization, and clinical asthma

Cited by 21 publications

References 41 publications

The Impact of Ambient Environmental Exposures to Microbial Products on Asthma Outcomes from Birth to Childhood

The Impact of Ambient Environmental Exposures to Microbial Products on Asthma Outcomes from Birth to Childhood

Value of Component Resolved Diagnostics to <b><i>Aspergillus fumigatus</i></b> in Patients with Upper Airway Complaints

Indoor Microbial Exposures and Chronic Lung Disease

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